Historically physicians recommend avoiding coffee in patients with arrhythmia and cardiovascular disease (CVD). However, data is lacking on safety of coffee in those with prevalent arrhythmia/CVD. We sought to investigate the associations between coffee and mortality/arrhythmia outcomes in prevalent conditionsMethods: The UK Biobank consists of 502543 people followed over > 10years. Self-reported coffee intake was divided… Continue reading 1186-021 / 21 – REGULAR COFFEE INTAKE IS ASSOCIATED WITH IMPROVED MORTALITY IN PREVALENT CARDIOVASCULAR DISEASE
1052-05 – GROUND, INSTANT, OR DECAFFEINATED COFFEE? IMPACT OF DIFFERENT COFFEE SUBTYPES ON INCIDENT ARRHYTHMIA, CARDIOVASCULAR DISEASE AND MORTALITY
Background: Population studies report health benefits from coffee intake. Coffee has up to 100 biologic compounds with caffeine most well known. The effects of coffee subtypes on cardiovascular(CV) outcomes is unclear. We aim to evaluate the associations between coffee subtypes and incident arrhythmia, CV disease (CVD), and total/ CV mortalityMethods: Participant responses to coffee amount and type(ground,… Continue reading 1052-05 – GROUND, INSTANT, OR DECAFFEINATED COFFEE? IMPACT OF DIFFERENT COFFEE SUBTYPES ON INCIDENT ARRHYTHMIA, CARDIOVASCULAR DISEASE AND MORTALITY
Association of midlife antibiotic use with subsequent cognitive function in women
The gut microbiome is increasingly recognized to play a role in cognition and dementia. Antibiotic use impacts the gut microbiome and has been linked with chronic disease. Despite these data, there is no evidence supporting an association between long-term antibiotic use in adults and cognitive function. We conducted a prospective population-based cohort study among 14,542… Continue reading Association of midlife antibiotic use with subsequent cognitive function in women
1056-05 – EFFECTS OF HABITUAL COFFEE CONSUMPTION ON INCIDENT CARDIOVASCULAR DISEASE, ARRHYTHMIA, AND MORTALITY: FINDINGS FROM UK BIOBANK
Background: Meta analyses report beneficial effects of coffee intake on incident cardiovascular outcomes, however earlier studies are limited by smaller sample sizes. The aim was to evaluate associations between coffee intake and incident arrhythmia, CVD, and mortality, utilising the UK BiobankMethods: The UK Biobank is a large prospective cohort with outcomes measured >10 years. Coffee… Continue reading 1056-05 – EFFECTS OF HABITUAL COFFEE CONSUMPTION ON INCIDENT CARDIOVASCULAR DISEASE, ARRHYTHMIA, AND MORTALITY: FINDINGS FROM UK BIOBANK
Association between lithium use and the incidence of dementia and its subtypes: A retrospective cohort study
BackgroundDementia is the leading cause of death in elderly Western populations. Preventative interventions that could delay dementia onset even modestly would provide a major public health impact. There are no disease-modifying treatments currently available. Lithium has been proposed as a potential treatment. We assessed the association between lithium use and the incidence of dementia and… Continue reading Association between lithium use and the incidence of dementia and its subtypes: A retrospective cohort study
Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines
Large-scale COVID-19 vaccinations are currently underway in many countries in response to the COVID-19 pandemic. Here, we report, besides generation of neutralizing antibodies, consistent alterations in hemoglobin A1c, serum sodium and potassium levels, coagulation profiles, and renal functions in healthy volunteers after vaccination with an inactivated SARS-CoV-2 vaccine. Similar changes had also been reported in… Continue reading Comprehensive investigations revealed consistent pathophysiological alterations after vaccination with COVID-19 vaccines
Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease
Importance Observational studies have consistently proposed cardiovascular benefits associated with light alcohol consumption, while recent genetic analyses (ie, mendelian randomization studies) have suggested a possible causal link between alcohol intake and increased risk of cardiovascular disease. However, traditional approaches to genetic epidemiology assume a linear association and thus have not fully evaluated dose-response estimates of… Continue reading Association of Habitual Alcohol Intake With Risk of Cardiovascular Disease
Digit ratios and their asymmetries as risk factors of developmental instability and hospitalization for COVID-19
COVID-19 presents with mild symptoms in the majority of patients but in a minority it progresses to acute illness and hospitalization. Here we consider whether markers for prenatal sex hormones and postnatal stressors on developmental instability, i.e. digit ratios and their directional and unsigned asymmetries, are predictive of hospitalization. We focus on six ratios: 2D:3D;… Continue reading Digit ratios and their asymmetries as risk factors of developmental instability and hospitalization for COVID-19
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders
Irritable bowel syndrome (IBS) results from disordered brain-gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant associations in a 23andMe… Continue reading Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders
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