Seven years ago, our clinical research group began towork in our hospital’s partial hospital program. Patientsare most commonly referred to the partial hospital becausethey are in crisis, are being transferred from a more intensivelevel of care (ie, inpatient services), or are referred fromoutpatient settings because they have not responded totreatment. While the average length of… Continue reading Psychiatric Patients Who Do Not Believe They Deserve to Get Better
Distressing dreams and risk of Parkinson’s disease: A population-based cohort study
BackgroundParkinson's disease (PD) is associated with alterations to the phenomenology of dreaming - including an increased frequency of distressing dreams. Whether distressing dreams may precede the development of PD is unknown. This study investigated the association between frequent distressing dreams and the risk of incident PD.Methods3818 men aged 67 years or older from the Osteoporotic… Continue reading Distressing dreams and risk of Parkinson’s disease: A population-based cohort study
Antibody–Invertase Fusion Protein Enables Quantitative Detection of SARS-CoV-2 Antibodies Using Widely Available Glucometers
Rapid diagnostics that can accurately inform patients of disease risk and protection are critical to mitigating the spread of the current COVID-19 pandemic and future infectious disease outbreaks. To be effective, such diagnostics must rely on simple, cost-effective, and widely available equipment and should be compatible with existing telehealth infrastructure to facilitate data access and… Continue reading Antibody–Invertase Fusion Protein Enables Quantitative Detection of SARS-CoV-2 Antibodies Using Widely Available Glucometers
The Impostor Phenomenon and causal attributions of positive feedback on intelligence tests
Highlights•The Impostor Phenomenon (IP) is characterized by attributional styles. •Participants completed numerical and verbal intelligence tasks. •Participants received positive feedback on their performance. •IP does not relate to actual performance in intelligence tests. •IP relates to attributing positive feedback to external-instable-specific causes. AbstractThe Impostor Phenomenon (IP) is characterized by an external-instable-specific attributional style (i.e., Impostors… Continue reading The Impostor Phenomenon and causal attributions of positive feedback on intelligence tests
Sustained Effects of Different Exercise Modalities on Physical and Mental Health in Patients With Coronary Artery Disease: A Randomized Clinical Trial
Twelve-week high-intensity interval training (HIIT), moderate-to-vigorousintensity continuous training (MICT), and Nordic walking (NW) have been shown to improve functional capacity, quality of life (QoL), and depression symptoms in patients with coronary artery disease. However, their prolonged effects or whether the improvements can be sustained remains unknown. In this study we compared the effects of 12… Continue reading Sustained Effects of Different Exercise Modalities on Physical and Mental Health in Patients With Coronary Artery Disease: A Randomized Clinical Trial
Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model
Elevation of soluble wild-type (WT) tau occurs in synaptic compartments in Alzheimer’s disease. We addressed whether tau elevation affects synaptic transmission at the calyx of Held in slices from mice brainstem. Whole-cell loading of WT human tau (h-tau) in presynaptic terminals at 10–20 µM caused microtubule (MT) assembly and activity-dependent rundown of excitatory neurotransmission. Capacitance… Continue reading Microtubule assembly by tau impairs endocytosis and neurotransmission via dynamin sequestration in Alzheimer’s disease synapse model
Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease
Predicting liver cancer riskNonalcoholic fatty liver disease (NAFLD) raises the risk of developing hepatocellular carcinoma (HCC), but this risk can be difficult to quantify and disease onset can still be difficult to catch early. Fujiwara et al. developed hepatic transcriptome and serum secretome–derived signatures to predict NAFLD-related HCC in patients over 15 years of observation.… Continue reading Molecular signatures of long-term hepatocellular carcinoma risk in nonalcoholic fatty liver disease
Vitamin D and brain health: an observational and Mendelian randomization study
BackgroundHigher vitamin D status has been suggested to have beneficial effects on the brain. ObjectivesTo investigate the association between 25-hydroxyvitamin D [25(OH)D], neuroimaging features, and the risk of dementia and stroke. MethodsWe used prospective data from the UK Biobank (37–73 y at baseline) to examine the association between 25(OH)D concentrations with neuroimaging outcomes (N =… Continue reading Vitamin D and brain health: an observational and Mendelian randomization study
Carbon dioxide rises beyond acceptable safety levels in children under nose and mouth covering: Results of an experimental measurement study in healthy children
AbstractNose and mouth covering (NMC) has been made compulsory for children in many countries during the Covid-19 pandemic. We wanted to determine the average CO2 levels in inhaled air with NMC in children between age 6 and 17. We used short term measurements under surgical masks and FFP2 masks according to European norm EN 149,… Continue reading Carbon dioxide rises beyond acceptable safety levels in children under nose and mouth covering: Results of an experimental measurement study in healthy children
