Physical exercise is effective in managing Parkinson's disease (PD), but the relative benefit of different exercise types remains unclear.ObjectivesTo compare the effects of different types of physical exercise in adults with PD on the severity of motor signs, quality of life (QoL), and the occurrence of adverse events, and to generate a clinically meaningful treatment… Continue reading Physical exercise for people with Parkinson’s disease: a systematic review and network meta‐analysis
Long-Term Effect of Weight Regain Following Behavioral Weight Management Programs on Cardiometabolic Disease Incidence and Risk: Systematic Review and Meta-Analysis
AbstractBACKGROUND:Behavioral weight management programs (BWMPs) enhance weight loss in the short term, but longer term cardiometabolic effects are uncertain as weight is commonly regained. We assessed the impact of weight regain after BWMPs on cardiovascular risk factors, diabetes, and cardiovascular disease.METHODS:Trial registries, 11 databases, and forward-citation searching (latest search, December 19) were used to identify… Continue reading Long-Term Effect of Weight Regain Following Behavioral Weight Management Programs on Cardiometabolic Disease Incidence and Risk: Systematic Review and Meta-Analysis
C-reactive protein partially mediates the inverse association between coffee consumption and risk of type 2 diabetes: The UK Biobank and the Rotterdam study cohorts
BackgroundCoffee is among the most consumed beverages worldwide. Coffee consumption has been associated with lower risk of type 2 diabetes mellitus (T2D), but underlying mechanisms are not well understood. We aimed to study the role of classic and novel-T2D biomarkers with anti- or pro-inflammatory activity in the association between habitual coffee intake and T2D risk.… Continue reading C-reactive protein partially mediates the inverse association between coffee consumption and risk of type 2 diabetes: The UK Biobank and the Rotterdam study cohorts
Subclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish CohortA Prospective Observational Cohort Study
Background:Coronary atherosclerosis may develop at an early age and remain latent for many years.Objective:To define characteristics of subclinical coronary atherosclerosis associated with the development of myocardial infarction.Design:Prospective observational cohort study.Setting:Copenhagen General Population Study, Denmark.Participants:9533 asymptomatic persons aged 40 years or older without known ischemic heart disease.Measurements:Subclinical coronary atherosclerosis was assessed with coronary computed tomography angiography… Continue reading Subclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish CohortA Prospective Observational Cohort Study
Retinal pathological features and proteome signatures of Alzheimer’s disease
Alzheimer’s disease (AD) pathologies were discovered in the accessible neurosensory retina. However, their exact nature and topographical distribution, particularly in the early stages of functional impairment, and how they relate to disease progression in the brain remain largely unknown. To better understand the pathological features of AD in the retina, we conducted an extensive histopathological… Continue reading Retinal pathological features and proteome signatures of Alzheimer’s disease
Burnout, Professionalism, and the Quality of US Health Care
Physician burnout is a major threat to health care quality, patient outcomes, and the vitality of the medical workforce.1 More than half of US physicians report at least 1 symptom of burnout—nearly twice the rate of the general working population—and many also experience depression, anxiety, or suicidal ideation.2 Burnout is estimated to cost the health… Continue reading Burnout, Professionalism, and the Quality of US Health Care
Comparisons Between Different Anti-osteoporosis Medications on Postfracture Mortality: A Population-Based Study
Osteoporosis is becoming a global epidemic in aging societies. Anti-osteoporotic medications can prevent fractures, and their pleiotropic effect on mortality is interesting but not well compared among each other.ObjectiveTo provide real-world evidence on the pleiotropic effect of different anti-osteoporotic medications on all-cause mortality, stratified by fracture site, sex, and age.MethodsThis longitudinal population-based postfracture cohort study,… Continue reading Comparisons Between Different Anti-osteoporosis Medications on Postfracture Mortality: A Population-Based Study
Anthocyanins as Promising Molecules Affecting Energy Homeostasis, Inflammation, and Gut Microbiota in Type 2 Diabetes with Special Reference to Impact of Acylation
Anthocyanins, the red-orange to blue-violet colorants present in fruits, vegetables, and tubers, have antidiabetic properties expressed via modulating energy metabolism, inflammation, and gut microbiota. Acylation of the glycosyl moieties of anthocyanins alters the physicochemical properties of anthocyanins and improves their stability. Thus, acylated anthocyanins with probiotic-like property and lower bioavailability are likely to have different… Continue reading Anthocyanins as Promising Molecules Affecting Energy Homeostasis, Inflammation, and Gut Microbiota in Type 2 Diabetes with Special Reference to Impact of Acylation
Association of Bone Mineral Density and Dementia: The Rotterdam Study
Background & Objective: Low bone mineral density and dementia commonly co-occur in the elderly, with bone loss accelerating in dementia patients due to physical inactivity and poor nutrition. However, uncertainty persists over the extent to which bone loss already exists prior to the onset of dementia. Therefore, we investigated how dementia risk was affected by… Continue reading Association of Bone Mineral Density and Dementia: The Rotterdam Study
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