Metabolomic and microbiome profiling reveals personalized risk factors for coronary artery disease

Complex diseases, such as coronary artery disease (CAD), are often multifactorial, caused by multiple underlying pathological mechanisms. Here, to study the multifactorial nature of CAD, we performed comprehensive clinical and multi-omic profiling, including serum metabolomics and gut microbiome data, for 199 patients with acute coronary syndrome (ACS) recruited from two major Israeli hospitals, and validated …

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A Meta-Analysis on the Global Prevalence, Risk factors and Screening of Coronary #Heart Disease in Non-alcoholic #Fatty Liver Disease

Background and AimsCardiovascular disease remains the leading cause of death in patients with non-alcoholic fatty liver disease (NAFLD). Studies examining the association of coronary heart disease (CHD) and NAFLD are cofounded by various cardiometabolic factors particularly diabetes and body mass index. Hence, we seek to explore such association by investigating the global prevalence, independent risk …

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Long-term night #shift work is associated with the risk of atrial #fibrillation and #coronary heart disease

The aim of this study was to test whether current and past night shift work was associated with incident atrial fibrillation (AF) and whether this association was modified by genetic vulnerability. Its associations with coronary heart disease (CHD), stroke, and heart failure (HF) were measured as a secondary aim. Methods and resultsThis cohort study included …

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Associations of #Job Strain, #Stressful Life Events, and Social Strain With Coronary Heart Disease in the Women’s Health Initiative Observational Study

The association between psychosocial stress and coronary heart disease (CHD) may be stronger in women than men and may differ across types of stressors. In this study, we assessed associations of psychosocial stressors, including job strain, stressful life events, and social strain with the incidence of CHD in women. Methods and Results We used longitudinal …

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Association of Hepatic #Steatosis with Major Adverse Cardiovascular Events, Independent of #Coronary Artery Disease

Hepatic steatosis has been associated with increased risk of major adverse cardiovascular events (MACE) but it is not clear whether steatosis is independently associated with risk of MACE. We investigated whether steatosis is associated with risk of MACE independently of the presence and extent of baseline coronary artery disease, assessed by comprehensive contrast-enhanced computed tomography …

Continue reading Association of Hepatic #Steatosis with Major Adverse Cardiovascular Events, Independent of #Coronary Artery Disease