Alzheimer’s disease (AD) pathologies were discovered in the accessible neurosensory retina. However, their exact nature and topographical distribution, particularly in the early stages of functional impairment, and how they relate to disease progression in the brain remain largely unknown. To better understand the pathological features of AD in the retina, we conducted an extensive histopathological… Continue reading Retinal pathological features and proteome signatures of Alzheimer’s disease
Burnout, Professionalism, and the Quality of US Health Care
Physician burnout is a major threat to health care quality, patient outcomes, and the vitality of the medical workforce.1 More than half of US physicians report at least 1 symptom of burnout—nearly twice the rate of the general working population—and many also experience depression, anxiety, or suicidal ideation.2 Burnout is estimated to cost the health… Continue reading Burnout, Professionalism, and the Quality of US Health Care
Comparisons Between Different Anti-osteoporosis Medications on Postfracture Mortality: A Population-Based Study
Osteoporosis is becoming a global epidemic in aging societies. Anti-osteoporotic medications can prevent fractures, and their pleiotropic effect on mortality is interesting but not well compared among each other.ObjectiveTo provide real-world evidence on the pleiotropic effect of different anti-osteoporotic medications on all-cause mortality, stratified by fracture site, sex, and age.MethodsThis longitudinal population-based postfracture cohort study,… Continue reading Comparisons Between Different Anti-osteoporosis Medications on Postfracture Mortality: A Population-Based Study
Anthocyanins as Promising Molecules Affecting Energy Homeostasis, Inflammation, and Gut Microbiota in Type 2 Diabetes with Special Reference to Impact of Acylation
Anthocyanins, the red-orange to blue-violet colorants present in fruits, vegetables, and tubers, have antidiabetic properties expressed via modulating energy metabolism, inflammation, and gut microbiota. Acylation of the glycosyl moieties of anthocyanins alters the physicochemical properties of anthocyanins and improves their stability. Thus, acylated anthocyanins with probiotic-like property and lower bioavailability are likely to have different… Continue reading Anthocyanins as Promising Molecules Affecting Energy Homeostasis, Inflammation, and Gut Microbiota in Type 2 Diabetes with Special Reference to Impact of Acylation
Association of Bone Mineral Density and Dementia: The Rotterdam Study
Background & Objective: Low bone mineral density and dementia commonly co-occur in the elderly, with bone loss accelerating in dementia patients due to physical inactivity and poor nutrition. However, uncertainty persists over the extent to which bone loss already exists prior to the onset of dementia. Therefore, we investigated how dementia risk was affected by… Continue reading Association of Bone Mineral Density and Dementia: The Rotterdam Study
Salt Sensitivity of Blood Pressure in Women
Several clinical and large population studies indicate that women are more salt-sensitive than men, yet the precise mechanisms by which the sexually dimorphic onset manifests remains incompletely understood. Here, we evaluate recent epidemiological data and highlight current knowledge from studies investigating sex-specific mechanisms of salt-sensitive blood pressure (SSBP). Emerging evidence indicates that women of all… Continue reading Salt Sensitivity of Blood Pressure in Women
Parent-Offspring Associations in Body Composition: Findings From the Southampton Women’s Survey Prospective Cohort Study
Children born to parents who are overweight or obese have a high risk of adult obesity, but it is unclear if transgenerational associations relating to unfavorable body composition differ by parent.ObjectiveTo examine differential mother-offspring and father-offspring associations in body composition in early childhood.MethodsA total of 240 mother-father-offspring trios from a prospective UK population-based pre-birth cohort… Continue reading Parent-Offspring Associations in Body Composition: Findings From the Southampton Women’s Survey Prospective Cohort Study
Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart FailureThe TRANSFORM-HF Randomized Clinical Trial
Although furosemide is the most commonly used loop diuretic in patients with heart failure, some studies suggest a potential benefit for torsemide.Objective To determine whether torsemide results in decreased mortality compared with furosemide among patients hospitalized for heart failure.Design, Setting, and Participants TRANSFORM-HF was an open-label, pragmatic randomized trial that recruited 2859 participants hospitalized with… Continue reading Effect of Torsemide vs Furosemide After Discharge on All-Cause Mortality in Patients Hospitalized With Heart FailureThe TRANSFORM-HF Randomized Clinical Trial
Cannabis legalization and childhood asthma in the United States: An ecologic analysis
Cannabis use is increasing among adults with children in the home particularly in states with cannabis legalization for medical (MCL) and/or recreational use (RCL), relative to states where cannabis use remains illegal at the state level. Exposure to secondhand smoke is a key risk factor for asthma among children. The objective of the current study… Continue reading Cannabis legalization and childhood asthma in the United States: An ecologic analysis
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