Importance Type 2 diabetes (T2D) is associated with the progression of cognitive dysfunction. Physical activity benefits cognition, but no evidence from randomized clinical trials has shown whether tai chi chuan has better long-term benefits than fitness walking in cognitive function for patients with T2D and mild cognitive impairment (MCI).Objective To compare the effectiveness of tai… Continue reading Effects of Tai Chi Chuan on Cognitive Function in Adults 60 Years or Older With Type 2 Diabetes and Mild Cognitive Impairment in ChinaA Randomized Clinical Trial
Would you prefer afour-day working week?
The findings suggest that a four-day week significantly reduces stress and illness in the workforce, and helps with worker retention.Some 71% of employees self-reported lower levels of “burnout”, and 39% said they were less stressed, compared to the start of the trial.Researchers found a 65% reduction in sick days, and a 57% fall in the… Continue reading Would you prefer afour-day working week?
Early Treatment with Hydroxychloroquine and Azithromycin: A ‘Real-Life’ Monocentric Retrospective Cohort Study of 30,423 COVID-19 Patients
AbstractObjective To estimate the comparative effectiveness of combination therapy with hydroxychloroquine (HCQ) and azithromycin for coronavirus disease 2019 (COVID-19)- related death based on a large monocentric cohort independent of investigators’ putative biases in a real-world setting.Design Retrospective monocentric cohort study, with comprehensive data collection authenticated by an external bailiff and death reports from a national… Continue reading Early Treatment with Hydroxychloroquine and Azithromycin: A ‘Real-Life’ Monocentric Retrospective Cohort Study of 30,423 COVID-19 Patients
Dietary sugar consumption and health: umbrella review
Objective To evaluate the quality of evidence, potential biases, and validity of all available studies on dietary sugar consumption and health outcomes.Design Umbrella review of existing meta-analyses.Data sources PubMed, Embase, Web of Science, Cochrane Database of Systematic Reviews, and hand searching of reference lists.Inclusion criteria Systematic reviews and meta-analyses of randomised controlled trials, cohort studies,… Continue reading Dietary sugar consumption and health: umbrella review
Prolonged Moderate-Intensity Exercise Does Not Increase Muscle Injury Markers in Symptomatic or Asymptomatic Statin Users
BackgroundStatin use may exacerbate exercise-induced skeletal muscle injury caused by reduced coenzyme Q10 (CoQ10) levels, which are postulated to produce mitochondrial dysfunction.ObjectivesWe determined the effect of prolonged moderate-intensity exercise on markers of muscle injury in statin users with and without statin-associated muscle symptoms. We also examined the association between leukocyte CoQ10 levels and muscle markers,… Continue reading Prolonged Moderate-Intensity Exercise Does Not Increase Muscle Injury Markers in Symptomatic or Asymptomatic Statin Users
Caffeine consumption as a risk factor for childhood and adolescence migraine
Background: Caffeine consumption is a risk factor for chronic daily headache but few studies have addressed relationships between pediatric patient caffeine levels and headache severity. We examined associations between serum and urine caffeine levels and headache severity in childhood and adolescent migraine cases.Methods: Levels of caffeine and caffeine metabolites in serum and urine samples were… Continue reading Caffeine consumption as a risk factor for childhood and adolescence migraine
Association of Early Adulthood Hypertension and Blood Pressure Change With Late-Life Neuroimaging Biomarkers
The association between hypertension developed before midlife and late-life brain health is understudied and, because of the cardioprotective benefits of estrogen before menopause, may differ by sex. Objective To assess the association of early adulthood hypertension and blood pressure (BP) change with late-life neuroimaging biomarkers and examine potential sex differences. Design, Setting, and Participants This cohort study… Continue reading Association of Early Adulthood Hypertension and Blood Pressure Change With Late-Life Neuroimaging Biomarkers
Sleep Patterns and the Risk of Acute Stroke: Results from the INTERSTROKE International Case-Control Study
Background and Objectives: Symptoms of sleep disturbance are common, and may represent important modifiable risk factors for stroke. We evaluated the association between a spectrum of sleep disturbance symptoms and risk of acute stroke in an international setting.Methods: INTERSTROKE is an international case-control study of patients presenting with first acute stroke and controls matched by… Continue reading Sleep Patterns and the Risk of Acute Stroke: Results from the INTERSTROKE International Case-Control Study
Effects of Time-Restricted Eating on Nonalcoholic Fatty Liver DiseaseThe TREATY-FLD Randomized Clinical Trial
Importance The efficacy and safety of time-restricted eating (TRE) on nonalcoholic fatty liver disease (NAFLD) remain uncertain.Objective To compare the effects of TRE vs daily calorie restriction (DCR) on intrahepatic triglyceride (IHTG) content and metabolic risk factors among patients with obesity and NAFLD.Design, Setting, and Participants This 12-month randomized clinical trial including participants with obesity… Continue reading Effects of Time-Restricted Eating on Nonalcoholic Fatty Liver DiseaseThe TREATY-FLD Randomized Clinical Trial
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