Increased aerobic exercise capacity, as a result of exercise training, has important health benefits. However, some individuals are resistant to improvements in exercise capacity, probably due to undetermined genetic and environmental factors. Here, we show that exercise-induced improvements in aerobic capacity are blunted and aerobic remodelling of skeletal muscle is impaired in several animal models… Continue reading #Hyperglycaemia is associated with impaired muscle signalling and #aerobic adaptation to exercise
Category: Diet
The ubiquitous flavonoid #quercetin is an atypical KCNQ #potassium channel activator
Many commonly consumed plants are used as folk medicines, often with unclear molecular mechanisms. Recent studies uncovered the ubiquitous and influential KCNQ family of voltage-gated potassium (Kv) channels as a therapeutic target for several medicinal plant compounds. Capers - immature flower buds of Capparis spinosa - have been consumed for food and medicinal purposes for… Continue reading The ubiquitous flavonoid #quercetin is an atypical KCNQ #potassium channel activator
Dietary intake of total, animal, and #plant #proteins and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of prospective cohort studies
..32 prospective cohort studies were included in the systematic review and 31 in the meta-analysis. During the follow-up period of 3.5 to 32 years, 113 039 deaths (16 429 from cardiovascular disease and 22 303 from cancer) occurred among 715 128 participants. Intake of total protein was associated with a lower risk of all cause mortality (pooled effect size… Continue reading Dietary intake of total, animal, and #plant #proteins and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of prospective cohort studies
High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger #Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease
The clinical spectra of irritable bowel syndrome (#IBS) and inflammatory bowel disease (#IBD) intersect to form a scantily defined overlap syndrome, termed pre-IBD. We show that increased Enterobacteriaceae and reduced Clostridia abundance distinguish the fecal microbiota of pre-IBD patients from IBS patients. A history of antibiotics in individuals consuming a high-fat diet was associated with… Continue reading High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger #Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease
Effect of Vitamin #D Supplementation on the Incidence of #Diabetes Mellitus
The effect of vitamin D supplementation on the risk of type 2 diabetes mellitus (T2DM) remains controversial because most randomized controlled trials (RCTs) have been small or have reported low doses of vitamin D.. ..Nine RCTs were included (43 559 participants). The mean age (standard deviation) was 63.5 (6.7) years. The RR for vitamin D… Continue reading Effect of Vitamin #D Supplementation on the Incidence of #Diabetes Mellitus
Women Have a Lower Risk of Nonalcoholic Fatty Liver Disease but a Higher Risk of Progression Vs Men: A Systematic Review and Meta-analysis
The risk of nonalcoholic fatty liver disease (NAFLD) and its progression may differ between men and women. We conducted a systematic review and meta-analysis to determine the relationship between sex and NAFLD, nonalcoholic steatohepatitis (NASH), and advanced NAFLD fibrosis.. ..Our final analysis comprised 54 studies. Samples sizes were 62,239 for the NAFLD analysis, 5428 for… Continue reading Women Have a Lower Risk of Nonalcoholic Fatty Liver Disease but a Higher Risk of Progression Vs Men: A Systematic Review and Meta-analysis
JOINT GUIDANCE ON VITAMIN D IN THE ERA OF COVID-19 FROM THE ASBMR, AACE, ENDOCRINE SOCIETY, ECTS, NOF, AND IOF
In response to the current COVID-19 global pandemic, and the attendant impact on outdoor physical activity and leisure time, the American Society for Bone and Mineral Research (ASBMR), American Association of Clinical Endocrinologists (AACE), Endocrine Society, European Calcified Tissue Society (ECTS), National Osteoporosis Foundation (NOF), and International Osteoporosis Foundation (IOF) remind individuals of the importance… Continue reading JOINT GUIDANCE ON VITAMIN D IN THE ERA OF COVID-19 FROM THE ASBMR, AACE, ENDOCRINE SOCIETY, ECTS, NOF, AND IOF
Intake of whole grain foods and risk of type 2 diabetes: results from three prospective cohort studies
..During 4 618 796 person years of follow-up, 18 629 participants with type 2 diabetes were identified. Total whole grain consumption was categorized into five equal groups of servings a day for the three cohorts. After adjusting for lifestyle and dietary risk factors for diabetes, participants in the highest category for total whole grain consumption had a 29%… Continue reading Intake of whole grain foods and risk of type 2 diabetes: results from three prospective cohort studies
Food & mood: a review of supplementary prebiotic and probiotic interventions in the treatment of anxiety and depression in adult
A bidirectional relationship exists between the brain and the gastrointestinal tract. Foods containing bacteria that positively influence the gastrointestinal microbiome are termed, probiotics; compounds that promote the flourishing of these bacteria are termed, prebiotics. Whether microbiome influencing therapies could treat psychiatric conditions, including depression and anxiety, is an area of interest. Presently, no established consensus… Continue reading Food & mood: a review of supplementary prebiotic and probiotic interventions in the treatment of anxiety and depression in adult
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