Preclinical evidence suggests that caloric restriction is an effective therapy for a number of cardiovascular insults. Whether caloric restriction has cardio-protective effects in humans is not well understood. The aim was to systematically review and meta-analyze human randomized control trials (RCTs) testing the effect of caloric restriction on blood pressure (BP) and cardiovascular function.. ..Thirty-two… Continue reading The effect of caloric restriction on blood pressure and cardiovascular function: A systematic review and meta-analysis of randomized controlled trials
Category: Diet
Does adequate physical activity attenuate the associations of alcohol and alcohol‐related cancer mortality? A pooled study of 54 686 British adults
The potential of physical activity (PA) to attenuate the effects of alcohol consumption on the risks of alcohol‐related cancer mortality is unknown. We used data from participants aged 30 years and over in 10 British population‐based surveys (Health Surveys for England 1994, 1997, 1998, 1999, 2003, 2004, 2006 and 2008 and the Scottish Health Surveys 1998… Continue reading Does adequate physical activity attenuate the associations of alcohol and alcohol‐related cancer mortality? A pooled study of 54 686 British adults
Nutriome–metabolome relationships provide insights into dietary intake and metabolism
Dietary assessment traditionally relies on self-reported data, which are often inaccurate and may result in erroneous diet–disease risk associations. We illustrate how urinary metabolic phenotyping can be used as an alternative approach to obtain information on dietary patterns. We used two multipass 24 h dietary recalls, obtained on two occasions on average 3 weeks apart, paired… Continue reading Nutriome–metabolome relationships provide insights into dietary intake and metabolism
Associations between consumption of dietary #fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort
..Our objectives were to assess the associations between the intake of DFs of different types [total (TDF), soluble (SF), insoluble (IF)] and from different sources (fruits, vegetables, whole grains, legumes, potatoes and tubers) and the risk of cardiovascular diseases (CVDs), cancer, type 2 diabetes (T2D), and mortality in the large-scale NutriNet-Santé prospective cohort (2009–2019).. ..T2D… Continue reading Associations between consumption of dietary #fibers and the risk of cardiovascular diseases, cancers, type 2 diabetes, and mortality in the prospective NutriNet-Santé cohort
Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans
Age-related vascular endothelial dysfunction is a major antecedent to cardiovascular diseases. We investigated whether increased circulating levels of the gut microbiome-generated metabolite trimethylamine-N-oxide induces endothelial dysfunction with aging. In healthy humans, plasma trimethylamine-N-oxide was higher in middle-aged/older (64±7 years) versus young (22±2 years) adults (6.5±0.7 versus 1.6±0.2 µmol/L) and inversely related to brachial artery flow-mediated… Continue reading Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans
Effect of #Zinc Supplementation vs Placebo on Mortality Risk and #HIV Disease Progression Among HIV-Positive Adults With Heavy #Alcohol Use
.. A total of 254 participants (184 men [72%]; mean [SD] age, 34 [6] years) were enrolled in the trial; 126 were randomized to receive zinc, and 128 were randomized to receive placebo. Participants had high CD4 cell counts (mean [SD], 521 [292] cells/mm3), and 188 (74%) reported heavy drinking in the past week. In… Continue reading Effect of #Zinc Supplementation vs Placebo on Mortality Risk and #HIV Disease Progression Among HIV-Positive Adults With Heavy #Alcohol Use
Association of Low to Moderate #Alcohol Drinking With #Cognitive Functions From Middle to Older Age Among US Adults
..The mean (SD) age of 19 887 participants was 61.8 (10.2) years, and the majority of the HRS participants were women (11 943 [60.1%]) and of white race/ethnicity (16 950 [85.2%]). Low to moderate drinking (<8 drinks per week for women and <15 drinks per week for men) was significantly associated with a consistently high cognitive function trajectory… Continue reading Association of Low to Moderate #Alcohol Drinking With #Cognitive Functions From Middle to Older Age Among US Adults
Metabolic Syndrome, Physical Activity, and Inflammation: A Cross-Sectional Analysis of 110 Circulating Biomarkers in Japanese Adults
Metabolic syndrome (MetS) is a systemic inflammatory state. Low physical activity (PA) could modify this patho-physiology or act as an independent contributor to inflammation. Previous studies of both conditions have identified altered levels of inflammation- and immune-related proteins based on limited sets of candidate markers.. ..MetS was significantly associated with levels of six markers: IL18R1… Continue reading Metabolic Syndrome, Physical Activity, and Inflammation: A Cross-Sectional Analysis of 110 Circulating Biomarkers in Japanese Adults
Trace element deficiency is highly prevalent and associated with infection and mortality in patients with alcoholic hepatitis
Malnutrition is common in patients with alcohol‐related liver disease and is associated with outcome in patients with alcoholic hepatitis. Trace elements (cobalt, copper, iron, selenium and zinc) are micronutrients essential for many cellular processes including antioxidant pathways. The prevalence and relevance of trace element deficiency is unknown in alcoholic hepatitis. ..Sera from 302 patients with… Continue reading Trace element deficiency is highly prevalent and associated with infection and mortality in patients with alcoholic hepatitis
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