The purpose of this study was to investigate factors influencing eating performance in older adults with dementia (OAWDs) in long-term care (LTC) facilities. MethodsThis cross-sectional study examined risk factors for compromised eating performance by comparing both independent and dependent older adults with dementia. The study participants were 117 OAWDs in LTC facilities in South Korea.… Continue reading Factors associated with #eating performance in older adults with #dementia in long-term care facilities: a cross-sectional study
Category: Diet
Peroxidation of n-3 and n-6 polyunsaturated #fatty acids in the acidic #tumor environment leads to ferroptosis-mediated anticancer effects
Highlights•n-3 and n-6 PUFAs preferentially accumulate in lipid droplets of acidic cancer cells •Excess LC-PUFAs undergo peroxidation and induce ferroptosis in acidic cancer cells •DGAT inhibitors prevent the formation of lipid droplets and promote ferroptosis •DGATi enhance the tumor growth inhibitory effects of dietary n-3 LC-PUFAs in mice SummaryTumor acidosis promotes disease progression through a… Continue reading Peroxidation of n-3 and n-6 polyunsaturated #fatty acids in the acidic #tumor environment leads to ferroptosis-mediated anticancer effects
#Zinc drives #vasorelaxation by acting in sensory nerves, endothelium and smooth muscle
Zinc, an abundant transition metal, serves as a signalling molecule in several biological systems. Zinc transporters are genetically associated with cardiovascular diseases but the function of zinc in vascular tone regulation is unknown. We found that elevating cytoplasmic zinc using ionophores relaxed rat and human isolated blood vessels and caused hyperpolarization of smooth muscle membrane.… Continue reading #Zinc drives #vasorelaxation by acting in sensory nerves, endothelium and smooth muscle
#Calcifediol treatment and #COVID-19-related outcomes
COVID-19 is a major health problem because of saturation of intensive care units (ICU) and mortality. Vitamin D has emerged as a potential treatment able to reduce the disease severity. ObjectiveTo elucidate the effect of calcifediol [25OHD3] treatment on COVID-19-related outcomes. DesignObservational cohort study from March to May, 2020. SettingPatients admitted to COVID-19 wards of… Continue reading #Calcifediol treatment and #COVID-19-related outcomes
Associations Between #Fruit Intake and Risk of #Diabetes in the AusDiab Cohort
Fruit, but not fruit juice, intake is inversely associated with type 2 diabetes mellitus (T2DM). However, questions remain about the mechanisms by which fruits may confer protection. ObjectiveThe aims of this work were to examine associations between intake of fruit types and 1) measures of glucose tolerance and insulin sensitivity and 2) diabetes at follow-up.… Continue reading Associations Between #Fruit Intake and Risk of #Diabetes in the AusDiab Cohort
#Coronary heart disease in mothers and fathers of adult children with #alcohol use disorders
Having a family member with an alcohol use disorder (AUD) may negatively affect a person’s health. Our aim was to study the long-term risk of coronary heart disease (CHD) in parents who have an offspring with AUD. DesignCohort study. Cox regression models and co-sibling analyses. SettingSweden. ParticipantsFrom population registers, we selected all parent-offspring pairs in… Continue reading #Coronary heart disease in mothers and fathers of adult children with #alcohol use disorders
The impact of #caffeine consumption on clinical symptoms in patients with #bipolar disorder: A systematic review
In healthy populations, caffeine appears to have beneficial effects on health; however, patients with bipolar disorder (BD) are routinely advised to limit caffeine use in psychoeducation programmes. We aimed to examine all literature reporting whether caffeine intake/withdrawal impacts the natural course of BD, in terms of clinical outcomes. MethodsPubMed, Embase and PsycINFO were searched (up… Continue reading The impact of #caffeine consumption on clinical symptoms in patients with #bipolar disorder: A systematic review
#Antihypertensive medication needs and blood pressure control with weight loss in the #Diabetes Remission Clinical Trial (DiRECT)
Our aim was to evaluate the safety and efficacy of a planned therapeutic withdrawal of all antihypertensive and diuretic medications, on commencing a formula low-energy diet replacement, targeting remission of type 2 diabetes. MethodsPost hoc analysis of changes in BP, antihypertensive medication prescriptions and symptoms during the initial total diet replacement phase was performed in… Continue reading #Antihypertensive medication needs and blood pressure control with weight loss in the #Diabetes Remission Clinical Trial (DiRECT)
#Mirtazapine in cancer-associated #anorexia and #cachexia: A double-blind placebo-controlled randomized trial
Few pharmacological interventions are available for cancer-associated anorexia and cachexia. Mirtazapine has been suggested for use in cancer-associated anorexia and cachexia. ObjectivesThis study was conducted to assess the efficacy and tolerability of mirtazapine in cancer-associated anorexia and cachexia. MethodsA double-blind placebo-controlled randomized trial. The study included 120 incurable solid tumour patients with anorexia (appetite loss… Continue reading #Mirtazapine in cancer-associated #anorexia and #cachexia: A double-blind placebo-controlled randomized trial
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