In observational studies, vitamin D has been inconsistently associated with reduced risk of several autoimmune diseases, and a large randomized, controlled trial has been lacking. Dietary marine-derived long-chain omega-3 (n−3) fatty acids decrease systemic inflammation and ameliorate symptoms in some autoimmune diseases, but no trials have tested whether supplementation lowers risk of developing autoimmune disease. …
Tag: omega-3
Dietary #DHA prevents cognitive impairment and inflammatory gene expression in aged male rats fed a diet enriched with refined #carbohydrates
•A processed-foods diet (PD) impaired learning and memory in aged male rats. •PD increased inflammatory genes in the hippocampus and amygdala of aged rats. •DHA supplementation prevented memory deficits in PD-fed aged rats. •DHA supplementation ameliorated increases in inflammatory gene expression. •PD consumption led to increased weight gain in young and aged rats. AbstractThe consumption …
Effect of Long-Term Marine #Omega-3 Fatty Acids Supplementation on the Risk of Atrial #Fibrillation in Randomized Controlled Trials of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
Some, but not all, large-scale randomized controlled trials (RCTs) investigating the effects of marine omega-3 fatty acids supplementation on cardiovascular outcomes have reported increased risks of atrial fibrillation (AF). The potential reasons for disparate findings may be dose related. Methods: The MEDLINE and Embase databases were searched for articles and abstracts published between January 1, …
Using an erythrocyte #fatty acid fingerprint to predict risk of all-cause #mortality: the Framingham Offspring Cohort
RBC long-chain omega-3 (n–3) fatty acid (FA) percentages (of total fatty acids) are associated with lower risk for total mortality, but it is unknown if a suite of FAs could improve risk prediction. ObjectivesThe objective of this study was to compare a combination of RBC FA levels with standard risk factors for cardiovascular disease (CVD) …
Peroxidation of n-3 and n-6 polyunsaturated #fatty acids in the acidic #tumor environment leads to ferroptosis-mediated anticancer effects
Highlights•n-3 and n-6 PUFAs preferentially accumulate in lipid droplets of acidic cancer cells •Excess LC-PUFAs undergo peroxidation and induce ferroptosis in acidic cancer cells •DGAT inhibitors prevent the formation of lipid droplets and promote ferroptosis •DGATi enhance the tumor growth inhibitory effects of dietary n-3 LC-PUFAs in mice SummaryTumor acidosis promotes disease progression through a …
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