In this multicentre, controlled, prospective endpoint trial, 19 084 hypertensive patients (10 614 men/8470 women, 60.5 ± 13.7 years of age) were assigned (1:1) to ingest the entire daily dose of ≥1 hypertension medications at bedtime (n = 9552) or all of them upon awakening (n = 9532) ..Patients of the bedtime, compared with the upon-waking, treatment-time regimen showed significantly lower hazard… Continue reading Bedtime hypertension treatment improves #cardiovascular risk reduction: the Hygia Chronotherapy Trial
Category: Cardiology
Population-Attributable Risk for Cardiovascular Disease Associated With #Hypertension in #Black Adults
..The multivariable-adjusted HR associated with hypertension was 1.91 (95% CI, 1.48-2.46) for CVD, 2.41 (95% CI,1.59-3.66) for coronary heart disease, 1.52 (95% CI, 1.01-2.30) for heart failure, and 2.20 (95% CI, 1.44-3.36) for stroke. The prevalence of hypertension was 53.2% among non-Hispanic black individuals. The PAR associated with hypertension was 32.5% (95% CI, 20.5%-43.6%) for… Continue reading Population-Attributable Risk for Cardiovascular Disease Associated With #Hypertension in #Black Adults
Association Between Limited English #Proficiency and Revisits and Readmissions After #Hospitalization for Patients With Acute and Chronic Conditions in Toronto, Ontario, Canada
Patients with limited English proficiency (LEP) in predominantly Anglophone settings face barriers to safe and high-quality health care.1,2 We examined whether emergency department (ED) visits or readmissions differed between English-proficient (EP) and LEP patients discharged with acute and chronic conditionsEP ..Patients with LEP and heart failure had an increased risk of a 30-day ED visit… Continue reading Association Between Limited English #Proficiency and Revisits and Readmissions After #Hospitalization for Patients With Acute and Chronic Conditions in Toronto, Ontario, Canada
Frequent #drinking is a more important risk factor for new-onset atrial #fibrillation than binge drinking: a nationwide population-based study
Compared with patients who drink twice per week (reference group), patients who drink once per week showed the lowest risk [hazard ratio (HR) 0.933, 95% confidence interval (CI) 0.916–0.950] and those who drink everyday had the highest risk for new-onset AF (HR 1.412, 95% CI 1.373–1.453), respectively. However, the amount of alcohol intake per drinking… Continue reading Frequent #drinking is a more important risk factor for new-onset atrial #fibrillation than binge drinking: a nationwide population-based study
#Rivaroxaban Versus Vitamin K Antagonist in #Antiphospholipid Syndrome: A Randomized Noninferiority Trial
After 3 years of follow-up, recurrent thrombosis occurred in 11 patients (11.6%) in the rivaroxaban group and 6 (6.3%) in the VKA group (RR in the rivaroxaban group, 1.83 [95% CI, 0.71 to 4.76]). Stroke occurred more commonly in patients receiving rivaroxaban (9 events) than in those receiving VKAs (0 events) (corrected RR, 19.00 [CI,… Continue reading #Rivaroxaban Versus Vitamin K Antagonist in #Antiphospholipid Syndrome: A Randomized Noninferiority Trial
Long-Term #Dabigatran Treatment Delays #Alzheimer’s Disease Pathogenesis in the TgCRND8 Mouse Model
Results Anticoagulation with dabigatran prevented memory decline, cerebral hypoperfusion, and toxic fibrin deposition in the AD mouse brain. In addition, long-term dabigatran treatment significantly reduced the extent of amyloid plaques, oligomers, phagocytic microglia, and infiltrated T cells by 23.7%, 51.8%, 31.3%, and 32.2%, respectively. Dabigatran anticoagulation also prevented AD-related astrogliosis and pericyte alterations, and maintained… Continue reading Long-Term #Dabigatran Treatment Delays #Alzheimer’s Disease Pathogenesis in the TgCRND8 Mouse Model
Self-rated #walking pace and all-cause, #cardiovascular disease and cancer mortality: individual participant pooled analysis of 50 225 walkers from 11 population British cohorts
Walking pace is associated with risk of premature mortality. Among participants who did not experience an event in the first 2 years of follow-up (n=49 731), walking at an average or brisk/fast pace was associated with a reduced risk of all-cause (20% (95% CI 12% to 28%) and 24% (95% CI 13% to 33%), respectively) and CVD… Continue reading Self-rated #walking pace and all-cause, #cardiovascular disease and cancer mortality: individual participant pooled analysis of 50 225 walkers from 11 population British cohorts
Dog Ownership and #Survival A Systematic Review and Meta-Analysis
Dog ownership has been associated with decreased cardiovascular risk. Recent reports have suggested an association of dog companionship with lower blood pressure levels, improved lipid profile, and diminished sympathetic responses to stress. Dog ownership was associated with a 24% risk reduction for all-cause mortality as compared to nonownership (relative risk, 0.76; 95% CI, 0.67–0.86) with… Continue reading Dog Ownership and #Survival A Systematic Review and Meta-Analysis
Long-Term Evolution of Premature #Coronary Artery Disease
They were age 40.1 ± 5.7 years, mainly men, smokers, with a family history of CAD or hypercholesterolemia. At baseline presentation, 91.2% underwent coronary revascularization, predominantly for acute MI (78.8%). Over a follow-up of 20 years, one-third (n = 264) of patients presented with a total of 399 ischemic events, and 36% had at least… Continue reading Long-Term Evolution of Premature #Coronary Artery Disease
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