..Both doses of lemborexant therapy demonstrated statistically significant greater changes from baseline on objective sleep onset as assessed by latency to persistent sleep (log transformed) that was measured using polysomnography at the end of 1 month of treatment (nights 29 and 30) compared with placebo.. For nights 29 and 30, as measured using polysomnography, the… Continue reading Comparison of #Lemborexant With Placebo and #Zolpidem Tartrate Extended Release for the Treatment of Older Adults With #Insomnia Disorder
Author: aledopress
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Risk Factors for Heart #Failure in the Community: Differences by Age and Ejection #Fraction
..the comorbidities with the largest attributable risk of heart failure were arrhythmia (48.7%), hypertension (28.4%), and coronary artery disease (33.9%); together these explained 73.0% of heart failure. Similar associations were observed for patients with reduced and preserved ejection fraction, with the exception of hypertension. The risk of heart failure attributable to hypertension was 2-fold higher… Continue reading Risk Factors for Heart #Failure in the Community: Differences by Age and Ejection #Fraction
Nightly #sleep duration, fragmentation, and quality and daily risk of #migraine
..migraine onset on the day immediately following the sleep period (day 0) and the following day (day 1). ..Sleep duration ≤6.5 hours and poor sleep quality were not associated with migraine on day 0 or day 1. Diary-reported low efficiency was associated with 39% higher odds of headache on day 1 (odds ratio [OR] 1.39,… Continue reading Nightly #sleep duration, fragmentation, and quality and daily risk of #migraine
Characteristics of Patients Experiencing Rehospitalization or Death After Hospital Discharge in a Nationwide Outbreak of #E-cigarette, or #Vaping, Product Use–Associated Lung Injury — United States, 2019
Some patients hospitalized for e-cigarette, or vaping, product use–associated lung injury (EVALI) have been rehospitalized or have died after hospital discharge.. ..Compared with other EVALI patients, rehospitalized patients and patients who died after hospital discharge were more likely to have one or more chronic conditions, including cardiac disease, chronic pulmonary disease, and diabetes, and to… Continue reading Characteristics of Patients Experiencing Rehospitalization or Death After Hospital Discharge in a Nationwide Outbreak of #E-cigarette, or #Vaping, Product Use–Associated Lung Injury — United States, 2019
#Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-#sucrose-diet-driven lipogenesis and body #fat accumulation
The objective was to examine the effectiveness of mate tea (MT, Ilex paraguariensis St. Hilaire) and caffeine from mate tea (MC) on in vitro lipid accumulation and in vivo diet-driven-obesity.. ..MC reduced lipid accumulation (41%) via downregulation of fatty acid synthase (Fasn) (39%) in 3T3-L1 adipocytes. Rats fed a high-fat-high-sucrose-diet and 0.1% of caffeine from… Continue reading #Caffeine, but not other phytochemicals, in mate tea (Ilex paraguariensis St. Hilaire) attenuates high-fat-high-#sucrose-diet-driven lipogenesis and body #fat accumulation
Association Between #Automotive Assembly Plant Closures and #Opioid Overdose Mortality in the United States
..Automotive assembly plant closures are culturally significant events that substantially erode local economic opportunities. ..Automotive assembly plant closures were associated with statistically significant increases in opioid overdose mortality. Five years after a plant closure, mortality rates had increased by 8.6 opioid overdose deaths per 100 000 individuals (95% CI, 2.6-14.6; P = .006) in exposed counties compared with… Continue reading Association Between #Automotive Assembly Plant Closures and #Opioid Overdose Mortality in the United States
#Protein Intake Greater than the RDA Differentially Influences Whole-Body Lean #Mass Responses to Purposeful Catabolic and Anabolic Stressors: A Systematic Review and Meta-analysis
Under stressful conditions such as energy restriction (ER) and physical activity, the RDA for protein of 0.8 g · kg−1 · d−1 may no longer be an appropriate recommendation. Under catabolic or anabolic conditions, higher protein intakes are proposed to attenuate the loss or increase the gain of whole-body lean mass, respectively.. ..Among all comparisons,… Continue reading #Protein Intake Greater than the RDA Differentially Influences Whole-Body Lean #Mass Responses to Purposeful Catabolic and Anabolic Stressors: A Systematic Review and Meta-analysis
Whole #milk compared with reduced-fat milk and childhood #overweight: a systematic review and meta-analysis
The majority of children in North America consume cow-milk daily. Children aged >2 y are recommended to consume reduced-fat (0.1–2%) cow-milk to lower the risk of obesity.. ..In 18 studies, higher cow-milk fat consumption was associated with lower child adiposity, and 10 studies did not identify an association. Meta-analysis included 14 of the 28 studies… Continue reading Whole #milk compared with reduced-fat milk and childhood #overweight: a systematic review and meta-analysis
Amount and Intensity of Leisure-Time #Physical Activity and Lower #Cancer Risk
To determine whether recommended amounts of leisure-time physical activity (ie, 7.5-15 metabolic equivalent task [MET] hours/week) are associated with lower cancer risk.. ..Engagement in recommended amounts of activity (7.5-15 MET hours/week) was associated with a statistically significant lower risk of 7 of the 15 cancer types studied, including colon (8%-14% lower risk in men), breast… Continue reading Amount and Intensity of Leisure-Time #Physical Activity and Lower #Cancer Risk
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