The effect of #trunk flexion angle on lower limb mechanics during #running

High trunk flexion during running impacts lower limb kinetics and kinematics. •Ground reaction forces increased significantly with greater trunk flexion. •Stride parameters and joint moments were affected by degree of trunk flexion. •Trunk position should be investigated as a contributing factor to running injury. AbstractTrunk flexion is an understudied biomechanical variable that potentially influences running… Continue reading The effect of #trunk flexion angle on lower limb mechanics during #running

Greater Adherence to Secondary Prevention Medications Improves Survival After #Stroke or Transient #Ischemic Attack: A Linked Registry Study

Although a target of 80% medication adherence is commonly cited, it is unclear whether greater adherence improves survival after stroke or transient ischemic attack (TIA). We investigated associations between medication adherence during the first year postdischarge, and mortality up to 3 years, to provide evidence-based targets for medication adherence. Methods:Retrospective cohort study of 1-year survivors… Continue reading Greater Adherence to Secondary Prevention Medications Improves Survival After #Stroke or Transient #Ischemic Attack: A Linked Registry Study

Limited protection against #SARS-CoV-2 infection and virus transmission after mRNA #vaccination

Stang and coworkers have recently reported in the Journal that “RT-PCR test results as gold standard for assessing and controlling infectiousness fail” (1). The authors analyzed two scenarios and used Ct25 and Ct30 as thresholds for infectiousness and conclude that more than the half of their patient cohort was unlikely to have been infectious, i.e.… Continue reading Limited protection against #SARS-CoV-2 infection and virus transmission after mRNA #vaccination

Safety and Efficacy of amplitude-modulated radiofrequency electromagnetic fields in advanced #hepatocellular carcinoma

Importance: Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. Despite the recent approval of several new agents, long-term disease control remains elusive for most patients. Administration of 27.12 MHz radiofrequency (RF) electromagnetic fields (EMF) by means of a spoon-shaped antenna (TheraBionic P1 device) placed on the anterior part of the tongue… Continue reading Safety and Efficacy of amplitude-modulated radiofrequency electromagnetic fields in advanced #hepatocellular carcinoma

Evaluation of serum #calcium differences in #hypertensive crises and control patients: A randomly matched case-control study

The role of calcium in blood pressure has been widely studied among hypertensive patients; however, no study has explored the role of calcium in hypertensive crises. The primary objective of this study is to evaluate the differences in serum calcium levels between hypertensive crises patients and a 1:1 random matched controls (age-, sex-, race-, diabetes,… Continue reading Evaluation of serum #calcium differences in #hypertensive crises and control patients: A randomly matched case-control study

#Ejaculation Frequency and Risk of #Prostate Cancer: Updated Results with an Additional Decade of Follow-up

Evidence suggests that ejaculation frequency may be inversely related to the risk of prostate cancer (PCa), a disease for which few modifiable risk factors have been identified. ObjectiveTo incorporate an additional 10 yr of follow-up into an original analysis and to comprehensively evaluate the association between ejaculation frequency and PCa, accounting for screening, clinically relevant… Continue reading #Ejaculation Frequency and Risk of #Prostate Cancer: Updated Results with an Additional Decade of Follow-up

Reinforcement learning links spontaneous cortical #dopamine impulses to reward

Extrasynaptic levels of dopamine in mouse cortex exhibit spontaneous impulses•Impulses are broadly distributed in amplitude and time, with a rate of about 0.01/s•Feedback was used to train mice to volitionally control their spontaneous impulses•Mice learned to reliably modulate dopamine impulses in order to receive a reward SummaryIn their pioneering study on dopamine release, Romo and… Continue reading Reinforcement learning links spontaneous cortical #dopamine impulses to reward

Long-term Dietary #Flavonoid Intake and Subjective #Cognitive Decline in US Men and Women

To prospectively examine the associations between long-term dietary flavonoids and subjective cognitive decline (SCD). Methods: We followed 49,493 women from the Nurses’ Health Study (NHS) (1984-2006) and 27,842 men from the Health Professionals Follow-up Study (HPFS) (1986-2002). Poisson regression was used to evaluate the associations between dietary flavonoids (flavonols, flavones, flavanones, flavan-3-ols, anthocyanins, polymeric flavonoids,… Continue reading Long-term Dietary #Flavonoid Intake and Subjective #Cognitive Decline in US Men and Women

Distribution of dietary #protein intake in daily meals influences skeletal #muscle hypertrophy via the muscle clock

Distribution of dietary protein across meals influences muscle hypertrophy•BCAAs are involved in hypertrophic effects of protein feeding distribution•Hypertrophic effects of protein feeding distribution require the muscle clock•Breakfast protein intake is correlated with skeletal muscle functions in older women SummaryThe meal distribution of proteins throughout the day is usually skewed. However, its physiological implications and the… Continue reading Distribution of dietary #protein intake in daily meals influences skeletal #muscle hypertrophy via the muscle clock