The group with epilepsy included in this study had a lower proportion of individuals with overweight and obesity than the general population (23.1% versus 42%) in 2015. However, the proportion of patients with obesity in the groups with DRE was significantly higher than that in the general population (17.9% versus 7.1%).•The J-shaped relationship between BMI… Continue reading Associations of #overweight and #obesity with drug-resistant #epilepsy
Author: aledopress
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lab alert: Changes to CDC RT-PCR for SARS-CoV-2 Testing
Audience: Individuals Performing COVID-19 Testing Level: Laboratory Alert After December 31, 2021, CDC will withdraw the request to the U.S. Food and Drug Administration (FDA) for Emergency Use Authorization (EUA) of the CDC 2019-Novel Coronavirus (2019-nCoV) Real-Time RT-PCR Diagnostic Panel, the assay first introduced in February 2020 for detection of SARS-CoV-2 only. CDC is providing… Continue reading lab alert: Changes to CDC RT-PCR for SARS-CoV-2 Testing
#Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of #SARS-CoV-2
There is an urgent need for antiviral agents that treat SARS-CoV-2 infection. We screened a library of 1,900 clinically safe drugs against OC43, a human beta-coronavirus that causes the common cold and evaluated the top hits against SARS-CoV-2. Twenty drugs significantly inhibited replication of both viruses in vitro. Eight of these drugs inhibited the activity… Continue reading #Masitinib is a broad coronavirus 3CL inhibitor that blocks replication of #SARS-CoV-2
Influence of Free #Fatty Acid Concentrations and #Weight Loss on Adipose Tissue Direct Free Fatty Acid Storage Rates
The factors that determine the recycling of free fatty acids (FFA) back into different adipose tissue depots via the direct storage pathway are not completely understood. ObjectiveTo assess the interactions between adipocyte factors and plasma FFA concentrations that determine regional FFA storage rates. DesignWe measured direct adipose tissue FFA storage rates before and after weight… Continue reading Influence of Free #Fatty Acid Concentrations and #Weight Loss on Adipose Tissue Direct Free Fatty Acid Storage Rates
The Relationship Between Prognostic #Nutritional Index and All-Cause #Mortality in Critically Ill Patients: A Retrospective Study
The effectiveness and prognostic value of the prognostic nutritional index (PNI) in critically ill patients are unknown. Hence, this study aimed to analyze the relationship between the PNI and all-cause mortality in critically ill patients. Patients and Methods: Patient data were obtained from the Multiparameter Intelligent Monitoring in Intensive Care III database. The relationship between… Continue reading The Relationship Between Prognostic #Nutritional Index and All-Cause #Mortality in Critically Ill Patients: A Retrospective Study
Is the cure really worse than the disease? The health impacts of #lockdowns during #COVID-19
Summary boxRestrictive non-pharmaceutical interventions against COVID-19 (known as ‘lockdowns’) are associated with health harms However, it is challenging to determine whether lockdowns have caused the harms or whether these harms are a direct consequence of the underlying health disaster of the pandemic Careful analysis of excess mortality suggests that lockdowns are not associated with large… Continue reading Is the cure really worse than the disease? The health impacts of #lockdowns during #COVID-19
#Gut-microbiota-targeted #diets modulate human immune status
Diet intervention with systems profiling reveals links in diet-microbiome-immune axis•High-fiber diet changes microbiome function and elicits personalized immune responses•Fermented-food diet increases microbiome diversity and decreases markers of inflammation SummaryDiet modulates the gut microbiome, which in turn can impact the immune system. Here, we determined how two microbiota-targeted dietary interventions, plant-based fiber and fermented foods, influence… Continue reading #Gut-microbiota-targeted #diets modulate human immune status
The #sulfur microbial diet is associated with increased risk of early-onset #colorectal cancer precursors
Diet may contribute to the increasing incidence of colorectal cancer (CRC) before age 50 (early-onset CRC). Microbial metabolism of dietary sulfur produces hydrogen sulfide (H2S), a gastrointestinal carcinogen that cannot be easily measured at scale. As a result, evidence supporting its role in early neoplasia is lacking. MethodsWe evaluated long-term adherence to the sulfur microbial… Continue reading The #sulfur microbial diet is associated with increased risk of early-onset #colorectal cancer precursors
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe #COVID-19
SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals present with isolated upper respiratory symptoms, suggesting potential to constrain viral pathology to the nasopharynx. Which cells SARS-CoV-2 primarily targets and how infection influences the respiratory epithelium remains incompletely understood. We performed scRNA-seq on nasopharyngeal swabs from 58 healthy and COVID-19 participants. During COVID-19, we… Continue reading Impaired local intrinsic immunity to SARS-CoV-2 infection in severe #COVID-19
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