Dietary #Carbohydrate and #Fat Intakes and Risk of #Mortality in the Japanese Population: the Japan Multi-Institutional Collaborative Cohort Study

BackgroundPrevious cohort studies have yielded contradictory findings regarding the associations of dietary carbohydrate and fat intakes with risks of mortality.ObjectivesWe examined long-term associations of carbohydrate and fat intakes with mortality.MethodsIn this cohort study, 34,893 men and 46,440 women aged 35–69 y (mean body mass index of 23.7 and 22.2 kg/m2, respectively) were followed up from the baseline survey (2004–2014)… Continue reading Dietary #Carbohydrate and #Fat Intakes and Risk of #Mortality in the Japanese Population: the Japan Multi-Institutional Collaborative Cohort Study

Association of nonalcoholic fatty #liver disease with #colorectal adenomatous #polyps and non-adenomatous polyps: a cross-sectional study

Aim This study aimed to investigate the association between non-alcoholic fatty liver disease (NAFLD) and both colorectal adenomatous polyps and non-adenomatous polyps, in order to provide evidence for the prevention of colorectal cancer (CRC) in patients with NAFLD.Methods A retrospective, cross-sectional study was conducted at the First People’s Hospital of Kunshan, Jiangsu, China. The study included 3028 adults who… Continue reading Association of nonalcoholic fatty #liver disease with #colorectal adenomatous #polyps and non-adenomatous polyps: a cross-sectional study

Medicine on the Move: Early Modern Travel and Remedies

Alun WitheyUniversity of Exeter Cross-posted from Dr Alun Withey As my new project on the history of travel, health risk and preparation begins to get underway, one of the things that I am thinking about is the place of travel within early modern medical remedy culture. What kinds of conditions could befall travellers? What did… Continue reading Medicine on the Move: Early Modern Travel and Remedies

Irisin reduces #amyloid-β by inducing the release of neprilysin from #astrocytes following downregulation of ERK-STAT3 signaling

A pathological hallmark of Alzheimer’s disease (AD) is the deposition of amyloid-β (Aβ) protein in the brain. Physical exercise has been shown to reduce Aβ burden in various AD mouse models, but the underlying mechanisms have not been elucidated. Irisin, an exercise-induced hormone, is the secreted form of fibronectin type-III-domain-containing 5 (FNDC5). Here, using a… Continue reading Irisin reduces #amyloid-β by inducing the release of neprilysin from #astrocytes following downregulation of ERK-STAT3 signaling

Jaundice: Understanding The Yellowing Of The Skin And Eyes

Jaundice: Understanding The Yellowing Of The Skin And Eyes Introduction Jaundice is a medical condition characterized by the yellowing of the skin, eyes, and mucous membranes. It occurs due to an excess of bilirubin, a yellow pigment produced during the breakdown of red blood cells. Jaundice can be a sign of underlying medical issues and… Continue reading Jaundice: Understanding The Yellowing Of The Skin And Eyes

Visceral and Subcutaneous #Abdominal #Fat Predict #Brain Volume Loss at Midlife in 10,001 Individuals

AbstractAbdominal fat is increasingly linked to brain health. A total of 10,001 healthy participants were scanned on 1.5T MRI with a short whole-body MR imaging protocol. Deep learning with FastSurfer segmented 96 brain regions. Separate models segmented visceral and subcutaneous abdominal fat. Regression analyses of abdominal fat types and normalized brain volumes were evaluated, controlling… Continue reading Visceral and Subcutaneous #Abdominal #Fat Predict #Brain Volume Loss at Midlife in 10,001 Individuals