ObjectiveModerate-to-vigorous physical activity (MVPA) improves glucose levels; however, whether its timing affects daily glycemic control remains unclear. This study aims to investigate the impact of lifestyle MVPA timing on daily glycemic control in sedentary adults with overweight/obesity and metabolic impairments.MethodsA total of 186 adults (50% women; age, 46.8 [SD 6.2] years) with overweight/obesity (BMI, 32.9… Continue reading Impact of #lifestyle moderate-to-vigorous #physical activity timing on #glycemic control in sedentary adults with #overweight/obesity and metabolic impairments
A Systematic REVIEW of #Autopsy findings in deaths after #covid-19 vaccination
Highlights•We found that 73.9% of deaths were directly due to or significantly contributed to by COVID-19 vaccination.•Our data suggest a high likelihood of a causal link between COVID-19 vaccination and death.•These findings indicate the urgent need to elucidate the pathophysiologic mechanisms of death with the goal of risk stratification and avoidance of death for the… Continue reading A Systematic REVIEW of #Autopsy findings in deaths after #covid-19 vaccination
#High-fat diet, #microbiome-gut-brain axis signaling, and #anxiety-like behavior in male rats
Obesity, associated with the intake of a high-fat diet (HFD), and anxiety are common among those living in modern urban societies. Recent studies suggest a role of microbiome-gut-brain axis signaling, including a role for brain serotonergic systems in the relationship between HFD and anxiety. Evidence suggests the gut microbiome and the serotonergic brain system together… Continue reading #High-fat diet, #microbiome-gut-brain axis signaling, and #anxiety-like behavior in male rats
Effects of #Cocoa Consumption on #Cardiometabolic Risk Markers: Meta-Analysis of Randomized Controlled Trials
Abstract: Background: We conducted a systematic review and meta-analysis to examine the effect of dietary intake of cocoa on anthropometric measurements, lipid and glycemic profiles, and blood pressure levels in adults, with and without comorbidities. Methods: The databases used were MEDLINE (PubMed), EMBASE, Web of Science, Cochrane, LILACS, and SciELO. The eligible studies were randomized… Continue reading Effects of #Cocoa Consumption on #Cardiometabolic Risk Markers: Meta-Analysis of Randomized Controlled Trials
Personalized brain circuit scores identify clinically distinct biotypes in #depression and #anxiety
There is an urgent need to derive quantitative measures based on coherent neurobiological dysfunctions or ‘biotypes’ to enable stratification of patients with depression and anxiety. We used task-free and task-evoked data from a standardized functional magnetic resonance imaging protocol conducted across multiple studies in patients with depression and anxiety when treatment free (n = 801) and after… Continue reading Personalized brain circuit scores identify clinically distinct biotypes in #depression and #anxiety
An ingestible device for #gastric electrophysiology
The ability to record high-quality electrophysiology data from the gastrointestinal tract and enteric nervous system is of use in understanding a variety of disorders and improving healthcare via early diagnosis. However, such measurements remain challenging because electrodes must be implanted surgically or worn on the skin, which results in a trade-off between signal quality and… Continue reading An ingestible device for #gastric electrophysiology
#Olfactory Impairment and the Risk of Major Adverse #Cardiovascular Outcomes in Older Adults
BackgroundOlfactory impairment is common in older adults and may be associated with adverse cardiovascular health; however, empirical evidence is sparse. We examined olfaction in relation to the risk of coronary heart disease (CHD), stroke, and congestive heart failure (CHF).Methods and ResultsThis study included 2537 older adults (aged 75.6±2.8 years) from the Health ABC (Health, Aging, and… Continue reading #Olfactory Impairment and the Risk of Major Adverse #Cardiovascular Outcomes in Older Adults
#Overweight in #Adolescence and Young Adulthood in Association With Adult #Cerebrovascular Disease: The NFBC1966 Study
BACKGROUND:Risk factors for cerebrovascular disease in adulthood are well known. However, research on individuals’ risk factors throughout their life span has been limited. This prospective cohort study aims to determine the effect of body mass index (BMI) and its changes in adolescence and young adulthood on early onset cerebrovascular disease.METHODS:This study includes 10 491 people (5185… Continue reading #Overweight in #Adolescence and Young Adulthood in Association With Adult #Cerebrovascular Disease: The NFBC1966 Study
#Glucagon-like peptide-1 receptor agonists and #stroke: A systematic review and meta-analysis of #cardiovascular outcome trials
Background:In patients surviving stroke, approximately 15% and 60% exhibit concurrent diabetes mellitus and overweight/obesity, respectively, necessitating heightened secondary prevention efforts. Despite glucagon-like peptide-1 receptor agonists (GLP-1 RAs) demonstrating improved outcomes for those with diabetes mellitus or obesity, their underutilization persists among eligible individuals. This systematic review and meta-analysis investigated the impact of GLP-1 RAs on… Continue reading #Glucagon-like peptide-1 receptor agonists and #stroke: A systematic review and meta-analysis of #cardiovascular outcome trials
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