Lifestyle habits after middle age significantly impact the maintenance of cognitive function in older adults. Nutritional intake is closely related to lifestyle habits; therefore, nutrition is a pivotal factor in the prevention of dementia in the preclinical stages. Matcha green tea powder (matcha), which contains epigallocatechin gallate, theanine, and caffeine, has beneficial effects on cognitive… Continue reading Effect of matcha green #tea on #cognitive functions and #sleep quality in older adults with cognitive decline: A randomized controlled study over 12 months
Precise Lubrication and Protection of #Cartilage Damage by Targeting #Hydrogel Microsphere
Osteoarthritis (OA) is a degenerative bone and joint disease characterized by decreased cartilage lubrication, leading to continuous wear and ultimately irreversible damage. This situation is particularly challenging for early-stage OA, as current bio-lubricants lack precise targeting for small inflammatory lesions. In this work, an antibody-mediated targeting hydrogel microspheres (HMS) is developed to precisely lubricate the… Continue reading Precise Lubrication and Protection of #Cartilage Damage by Targeting #Hydrogel Microsphere
Acute #Kidney Injury and Its Association With #Dementia and Specific Dementia Types
Background and ObjectivesPreclinical studies suggest that acute kidney injury (AKI) results in biochemical and pathologic changes in the brain. We aimed to explore the association between experiencing AKI and subsequent risks of developing dementia.MethodsWe conducted a study involving individuals aged 65 years and older in Stockholm from 2006 to 2019, who were free from dementia… Continue reading Acute #Kidney Injury and Its Association With #Dementia and Specific Dementia Types
#Hormone Therapy and Biological #Aging in Postmenopausal Women
Importance Menopause is associated with biological aging, and hormone therapy (HT) is associated with health outcomes in postmenopausal women.Objective To evaluate the association between HT use and discrepancies between chronological and biological age in postmenopausal women as well as the potential modifying role of socioeconomic status (SES).Design, Setting, and Participants This population-based, retrospective cohort study included postmenopausal women… Continue reading #Hormone Therapy and Biological #Aging in Postmenopausal Women
#Lignan Intake and Type 2 #Diabetes Incidence Among US Men and Women
Importance Lignans are phytoestrogens abundant in Western diets and may be associated with type 2 diabetes (T2D) risk.Objective To prospectively investigate associations between lignan intake and T2D incidence.Design, Setting, and Participants Population-based cohort study of US men and women enrolled in the Nurses’ Health Study (NHS, 1984-2018), NHSII (1991-2019), and Health Professionals Follow-Up Study (HPFS, 1986-2020), as well… Continue reading #Lignan Intake and Type 2 #Diabetes Incidence Among US Men and Women
#Accelerometer-derived ‘weekend warrior’ physical #activity pattern and #brain health
Extensive evidence shows the beneficial effect of adhering to a regular physical activity (PA) pattern on brain health. However, whether the ‘weekend warrior’ pattern, characterized by concentrated moderate-to-vigorous PA (MVPA) over 1–2 days, is associated with brain health is unclear. Here, we perform a prospective cohort study including 75,629 participants from the UK Biobank with validated… Continue reading #Accelerometer-derived ‘weekend warrior’ physical #activity pattern and #brain health
Comprehensive Association Analyses of Extraintestinal Manifestations in #Inflammatory Bowel Disease
Background & AimsPatients with inflammatory bowel disease (IBD) frequently develop extraintestinal manifestations (EIMs) that contribute substantially to morbidity. We assembled the largest multicohort data set to date to investigate the clinical, serologic, and genetic factors associated with EIM complications in IBD.MethodsData were available in 12,083 unrelated European ancestry IBD cases with presence or absence of… Continue reading Comprehensive Association Analyses of Extraintestinal Manifestations in #Inflammatory Bowel Disease
#Aspirin Use and Incidence of #Colorectal Cancer According to Lifestyle Risk
Importance Aspirin reduces the risk of colorectal cancer (CRC). Identifying individuals more likely to benefit from regular aspirin use for CRC prevention is a high priority.Objective To assess whether aspirin use is associated with the risk of CRC across different lifestyle risk factors.Design, Setting, and Participants A prospective cohort study among women in the Nurses’ Health Study (1980-2018)… Continue reading #Aspirin Use and Incidence of #Colorectal Cancer According to Lifestyle Risk
Effect of #chair placement on physicians’ #behavior and patients’ satisfaction: randomized deception trial
Objective To evaluate the effect of chair placement on length of time physicians sit during a bedside consultation and patients’ satisfaction.Design Single center, double blind, randomized controlled deception trial.Setting County hospital in Texas, USA.Participants 51 hospitalist physicians providing direct care services, and 125 observed encounters of patients who could answer four orientation questions correctly before study entry, April 2022… Continue reading Effect of #chair placement on physicians’ #behavior and patients’ satisfaction: randomized deception trial
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