Although severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was detected in faeces of patients with COVID-19, the activity and infectivity of the virus in the GI tract during disease course is largely unknown. We investigated temporal transcriptional activity of SARS-CoV-2 and its association with longitudinal faecal microbiome alterations in patients with COVID-19.. Seven (46.7%)… Continue reading Depicting #SARS-CoV-2 faecal viral activity in association with #gut microbiota composition in patients with COVID-19
Natural history of acute #kidney disease in patients with #cirrhosis
In 2012, KDIGO group proposed new definitions for Acute Kidney Injury (AKI), Acute Kidney Disease (AKD) and Chronic Kidney Disease (CKD). According to the definition adapted by the International Club of Ascites (ICA), AKI has been extensively investigated in patients with cirrhosis. On the contrary, there are currently no data on the epidemiology and clinical… Continue reading Natural history of acute #kidney disease in patients with #cirrhosis
Effectiveness of #Curcuma longa Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee #Osteoarthritis
To determine the efficacy of Curcuma longa extract (CL) for reducing knee symptoms and effusion–synovitis in patients with symptomatic knee osteoarthritis and knee effusion–synovitis.. ..2 capsules of CL (n = 36) or matched placebo (n = 34) per day for 12 weeks. Measurements: The 2 primary outcomes were changes in knee pain on a visual… Continue reading Effectiveness of #Curcuma longa Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee #Osteoarthritis
It’s surprisingly nice to hear you: Misunderstanding the impact of #communication media can lead to suboptimal choices of how to connect with others.
Positive social connections improve wellbeing. Technology increasingly affords a wide variety of media that people can use to connect with others, but not all media strengthen social connection equally. Optimizing wellbeing, therefore, requires choosing how to connect with others wisely. We predicted that people’s preferences for communication media would be at least partly guided by… Continue reading It’s surprisingly nice to hear you: Misunderstanding the impact of #communication media can lead to suboptimal choices of how to connect with others.
Warmth Prevents #Bone Loss Through the Gut #Microbiota
Osteoporosis is the most prevalent metabolic bone disease, characterized by low bone mass and microarchitectural deterioration. Here, we show that warmth exposure (34°C) protects against ovariectomy-induced bone loss by increasing trabecular bone volume, connectivity density, and thickness, leading to improved biomechanical bone strength in adult female, as well as in young male mice. Transplantation of… Continue reading Warmth Prevents #Bone Loss Through the Gut #Microbiota
An atlas on risk factors for type 2 #diabetes: a wide-angled Mendelian randomisation study
..We found evidence of causal associations between 34 exposures (19 risk factors and 15 protective factors) and type 2 diabetes. Insomnia was identified as a novel risk factor (OR 1.17 [95% CI 1.11, 1.23]). The other 18 risk factors were depression, systolic BP, smoking initiation, lifetime smoking, coffee (caffeine) consumption, plasma isoleucine, valine and leucine,… Continue reading An atlas on risk factors for type 2 #diabetes: a wide-angled Mendelian randomisation study
Effects of Intensive Blood Pressure Treatment on Orthostatic #Hypotension
Although intensive blood pressure (BP)–lowering treatment reduces risk for cardiovascular disease, there are concerns that it might cause orthostatic hypotension (OH).. ..Randomized trials of BP pharmacologic treatment (more intensive BP goal or active agent) that involved more than 500 adults with hypertension or elevated BP and that were 6 months or longer in duration. Trial… Continue reading Effects of Intensive Blood Pressure Treatment on Orthostatic #Hypotension
Ultra-processed #food consumption and the risk of short telomeres in an elderly population of the Seguimiento Universidad de Navarra (SUN) Project
Telomere length (TL) is a marker of biological age that may be affected by dietary factors through oxidation and inflammation mechanisms. In addition, ultra-processed food (UPF) consumption has increased worldwide and it has been associated with the risk of developing several diseases.. ..This is a cross-sectional study of 886 participants (645 men and 241 women)… Continue reading Ultra-processed #food consumption and the risk of short telomeres in an elderly population of the Seguimiento Universidad de Navarra (SUN) Project
Association of #Hypertension With the Risk and Severity of #Epistaxis
..Among the 35 749 patients in the hypertension cohort (20 579 men [57.6%]; median age, 52 years [interquartile range, 45-62 years]) the incidence rate (IR) of epistaxis was 32.97 per 10 000 persons (95% CI, 30.57-35.51 per 10 000 persons); among the 35 749 individuals in the comparison cohort (20 910 men [58.5%]; median age, 52 years [interquartile range, 45-62 years]),… Continue reading Association of #Hypertension With the Risk and Severity of #Epistaxis
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