It is uncertain whether depressive symptoms are independently associated with subsequent risk of cardiovascular diseases (CVDs).. ..Primary outcomes were incident fatal or nonfatal coronary heart disease (CHD), stroke, and CVD (composite of the 2). Hazard ratios (HRs) per 1-SD higher log CES-D or PHQ-2 adjusted for age, sex, smoking, and diabetes were reported. Results Among… Continue reading Association Between #Depressive Symptoms and Incident #Cardiovascular Diseases
#Apathy in presymptomatic genetic frontotemporal #dementia predicts cognitive decline and is driven by structural brain changes
Apathy adversely affects prognosis and survival of patients with frontotemporal dementia (FTD). We test whether apathy develops in presymptomatic genetic FTD, and is associated with cognitive decline and brain atrophy.. ..Results Apathy severity increased over time in presymptomatic carriers, but not in non‐carriers. In presymptomatic carriers, baseline apathy predicted cognitive decline over two years, but… Continue reading #Apathy in presymptomatic genetic frontotemporal #dementia predicts cognitive decline and is driven by structural brain changes
#Lipoprotein (a) and the risk of elevated #depressive symptoms: The Multi-Ethnic Study of Atherosclerosis
Previous studies suggested a potential relationship between plasma lipoprotein (a) [Lp(a)] and elevated depressive symptoms. We aimed to investigate any such relationship in the Multi-Ethnic Study of Atherosclerosis participants who were free of cardiovascular events. Analysis included 4938 participants without elevated depressive symptoms and with Lp(a) levels measured at baseline. Participants were examined at four… Continue reading #Lipoprotein (a) and the risk of elevated #depressive symptoms: The Multi-Ethnic Study of Atherosclerosis
#COVID-19 #Symptoms: Longitudinal Evolution and Persistence in Outpatient Settings
..Discussion: Coronavirus disease 2019 can persist and result in prolonged illness. Our study shows persistence of symptoms in a third of ambulatory patients 30 to 45 days after diagnosis even if we assume that those lost to follow-up were all asymptomatic. Fatigue, dyspnea, and loss of taste or smell were the main persistent symptoms. These… Continue reading #COVID-19 #Symptoms: Longitudinal Evolution and Persistence in Outpatient Settings
Changes in Body #Mass Index Are Related to Faster #Cognitive Decline Among African American Older Adults
The purpose of this study was to: (1) examine relationships between body mass index (BMI) stability and cognitive decline in older African Americans; and (2) investigate differences in the relationships between women and men.. ..Participants (n = 671; mean age = 73.5 years; standard deviation = 6.2 years) were included in the present analysis if they were… Continue reading Changes in Body #Mass Index Are Related to Faster #Cognitive Decline Among African American Older Adults
#IgA dominates the early neutralizing antibody response to #SARS-CoV-2
Abstract Humoral immune responses are typically characterized by primary IgM antibody responses followed by secondary antibody responses associated with immune memory and comprised of of IgG, IgA and IgE. Here we measured acute humoral responses to SARS-CoV-2, including the frequency of antibody-secreting cells and the presence of SARS-CoV-2-specific neutralizing antibodies in the serum, saliva and… Continue reading #IgA dominates the early neutralizing antibody response to #SARS-CoV-2
#Blood type #diets lack supporting evidence: a systematic review
Background: Diets that are based on the ABO blood group system have been promoted over the past decade and claim to improve health and decrease risk of disease. To our knowledge, the evidence to support the effectiveness of blood type diets has not previously been assessed in the scientific literature. Objective: In this current systematic… Continue reading #Blood type #diets lack supporting evidence: a systematic review
Association between circulating #vascular-related microRNAs and an increase in blood #pressure: a 5-year longitudinal population-based study
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression and play essential roles in the pathogenesis of cardiovascular disease. Previous cross-sectional studies showed that the levels of several circulating miRNA are associated with hypertension, but there are no prospective longitudinal studies using a general population. The aim of this study is to evaluate the… Continue reading Association between circulating #vascular-related microRNAs and an increase in blood #pressure: a 5-year longitudinal population-based study
Human #Health and Ocean #Pollution
..Human Health Findings: Methylmercury and PCBs are the ocean pollutants whose human health effects are best understood. Exposures of infants in utero to these pollutants through maternal consumption of contaminated seafood can damage developing brains, reduce IQ and increase children’s risks for autism, ADHD and learning disorders. Adult exposures to methylmercury increase risks for cardiovascular… Continue reading Human #Health and Ocean #Pollution
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