Although the safety of labor epidural analgesia (LEA) for neonates has been well documented, the long-term health effects of LEA on offspring remain to be investigated... ..Among the cohort of 147 895 singleton children (74 425 boys [50.3%]; mean [SD] gestational age at delivery, 38.9 [1.5] weeks), 109 719 (74.2%) were exposed to maternal LEA. Fever during labor… Continue reading Association Between #Epidural Analgesia During Labor and Risk of #Autism Spectrum Disorders in Offspring
Comparative evaluation of topical diclofenac sodium vs topical Ibuprofen in the treatment of #seborrheic keratosis.
In 2016, a case of seborrheic keratosis was successfully treated with diclofenac gel 3%. Diclofenac gel mechanism of action is most likely through induction of apoptosis. This study included 30 patients with multiple seborrheic keratosis. One lesion was treated with topical diclofenac sodium gel 1% and another lesion with topical ibuprofen gel applied twice daily… Continue reading Comparative evaluation of topical diclofenac sodium vs topical Ibuprofen in the treatment of #seborrheic keratosis.
#Remdesivir for the Treatment of #Covid-19 — Final Report
Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (Covid-19), no antiviral agents have yet been shown to be efficacious.. ..A total of 1062 patients underwent randomization (with 541 assigned to remdesivir and 521 to placebo). Those who received remdesivir had a median recovery time of 10 days (95% confidence… Continue reading #Remdesivir for the Treatment of #Covid-19 — Final Report
Contamination and washing of cloth #masks and risk of infection among hospital health workers in Vietnam: a post hoc analysis of a randomised controlled trial
In a previous randomised controlled trial (RCT) in hospital healthcare workers (HCWs), cloth masks resulted in a higher risk of respiratory infections compared with medical masks. This was the only published RCT of cloth masks at the time of the COVID-19 pandemic.. ..Viral contamination with rhinovirus was identified on both used medical and cloth masks.… Continue reading Contamination and washing of cloth #masks and risk of infection among hospital health workers in Vietnam: a post hoc analysis of a randomised controlled trial
#Ageing attenuates the effect of extracellular hyperosmolality on whole‐body #heat exchange during exercise‐heat #stress
Key points In humans, hypohydration attenuates sweat secretion and attenuates whole‐body heat loss, probably to mitigate further fluid losses and thereby support blood pressure regulation. Recently, however, we demonstrated that the hypohydration‐mediated reduction in net whole‐body heat exchange (evaporative heat loss – dry heat gain) was blunted in middle‐aged compared to younger men during moderate… Continue reading #Ageing attenuates the effect of extracellular hyperosmolality on whole‐body #heat exchange during exercise‐heat #stress
The #triglyceride- #glucose index is associated with the severity of hepatic #steatosis and the presence of liver #fibrosis in non-alcoholic fatty liver disease: a cross-sectional study in Chinese adults
The triglyceride-glucose index (TyG) is a reliable predictor of non-alcoholic fatty liver disease (NAFLD). Its association with the severity of hepatic steatosis and liver fibrosis in NAFLD is poorly understood. This study evaluated the relationship between these factors in NAFLD. ..The TyG index was significantly correlated with the severity of hepatic steatosis and the presence… Continue reading The #triglyceride- #glucose index is associated with the severity of hepatic #steatosis and the presence of liver #fibrosis in non-alcoholic fatty liver disease: a cross-sectional study in Chinese adults
Genetic and Environmental Influences on Blood #Pressure and Body #Mass Index in the National Academy of Sciences–National Research Council World War II Veteran Twin Registry
Blood pressure (BP) and obesity phenotypes may covary due to shared genetic or environmental factors or both. Furthermore, it is possible that the heritability of BP differs according to obesity status—a form of G×E interaction. This hypothesis has never been tested in White twins. The present study included 15 924 White male twin pairs aged between… Continue reading Genetic and Environmental Influences on Blood #Pressure and Body #Mass Index in the National Academy of Sciences–National Research Council World War II Veteran Twin Registry
Early experience with convalescent #plasma as immunotherapy for #COVID‐19 in China: Knowns and unknowns
In the absence of a vaccine or specific drug treatment options for coronavirus disease (COVID‐19), attention has been shifted in China to the possible therapeutic use of convalescent plasma. COVID‐19 convalescent plasma (CCP) is currently under investigation. We summarized clinical studies and other research data available as of 5 May 2020 on CCP therapy according… Continue reading Early experience with convalescent #plasma as immunotherapy for #COVID‐19 in China: Knowns and unknowns
Neurofilament light chain in the vitreous humor of the #eye
Neurofilament light chain (NfL) is a promising biomarker of neurodegeneration in the cerebrospinal fluid and blood. This study investigated the presence of NfL in the vitreous humor and its associations with amyloid beta, tau, inflammatory cytokines and vascular proteins, apolipoprotein E (APOE) genotypes, Mini-Mental State Examination (MMSE) scores, systemic disease, and ophthalmic diseases.. ..NfL was… Continue reading Neurofilament light chain in the vitreous humor of the #eye
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