The presence of periodontal diseases (PDs) often strongly correlates with other severe chronic inflammatory conditions, including cardiovascular disease, diabetes, and arthritis. However, the mechanisms through which these diseases interact are unclear. In PD, tissue and bone destruction in the mouth is driven by elevated recruitment of polymorphonuclear neutrophils (PMNs), which are primed and recruited from… Continue reading #Periodontal Inflammation Primes the Systemic Innate #Immune Response
Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes
Finerenone, a nonsteroidal, selective mineralocorticoid receptor antagonist, reduced albuminuria in short-term trials involving patients with chronic kidney disease (CKD) and type 2 diabetes. However, its long-term effects on kidney and cardiovascular outcomes are unknown. ..During a median follow-up of 2.6 years, a primary outcome event occurred in 504 of 2833 patients (17.8%) in the finerenone… Continue reading Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes
#Acupuncture of different treatment frequencies in knee #osteoarthritis: a pilot randomised controlled trial
This 16-week randomised controlled trial (8-week treatment followed by 8-week follow-up) evaluated the symptomatic improvement in patients with knee osteoarthritis on 3 sessions per week of acupuncture (TSWA) compared to 1 session per week of acupuncture (OSWA). Sixty participants were randomised to either the TSWA or the OSWA group in a 1:1 ratio. The primary… Continue reading #Acupuncture of different treatment frequencies in knee #osteoarthritis: a pilot randomised controlled trial
#Empagliflozin treatment effects across categories of baseline #HbA1c, body #weight and blood #pressure as an add‐on to metformin in patients with type 2 diabetes
In EMPA‐REG MET, in patients with type 2 diabetes mellitus (T2DM) on stable background metformin (≥1500 mg/day), empagliflozin versus placebo significantly improved glycated haemoglobin (HbA1c), body weight (BW), and systolic blood pressure (SBP) over 24 and ≤76 weeks. This analysis investigated empagliflozin treatment effects by baseline cardio‐metabolic factors.. ..In total, 637 patients (56.7% males; mean [SD]… Continue reading #Empagliflozin treatment effects across categories of baseline #HbA1c, body #weight and blood #pressure as an add‐on to metformin in patients with type 2 diabetes
#BMI and All‐Cause #Mortality in a Population‐Based Cohort in Rural South Africa
..The cohort consisted of 9,728 individuals. In adjusted models, those with BMI of 25.0 to 29.9 kg/m2 or 30.0 to 34.9 kg/m2 had a lower hazard of death (adjusted hazard ratio: 0.80; 95% CI: 0.69‐0.92 and adjusted hazard ratio: 0.75; 95% CI: 0.60‐0.93, respectively) compared with those with BMI of 18.5 to 24.9 kg/m2. Conclusions… Continue reading #BMI and All‐Cause #Mortality in a Population‐Based Cohort in Rural South Africa
Trends in #Physician #Voting Practices in California, New York, and Texas, 2006-2018
From 1996 to 2002, eligible physicians voted approximately 9 percentage points less than the general population.1 Since then, physician voter engagement has not been reported. We investigated physician voter participation, voter registration, and voter turnout from 2006 through 2018 in California, New York, and Texas, which are states with the largest number of physicians.. ..Discussion… Continue reading Trends in #Physician #Voting Practices in California, New York, and Texas, 2006-2018
Nonsteroidal Anti-Inflammatory Drugs (#NSAIDs): Drug Safety Communication – Avoid Use of NSAIDs in #Pregnancy at 20 Weeks or Later
FDA is warning that use of NSAIDs around 20 weeks or later in pregnancy may cause rare but serious kidney problems in an unborn baby. This can lead to low levels of amniotic fluid surrounding the baby and possible complications. For prescription NSAIDs, FDA is requiring changes to the prescribing information to describe the risk… Continue reading Nonsteroidal Anti-Inflammatory Drugs (#NSAIDs): Drug Safety Communication – Avoid Use of NSAIDs in #Pregnancy at 20 Weeks or Later
Effect of #Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With #COVID-19 Pneumonia
The coronavirus disease 2019 (COVID-19) pandemic is threatening billions of people worldwide. Tocilizumab has shown promising results in retrospective studies in patients with COVID-19 pneumonia with a good safety profile.. ..Patients in the experimental arm received intravenous tocilizumab within 8 hours from randomization (8 mg/kg up to a maximum of 800 mg), followed by a… Continue reading Effect of #Tocilizumab vs Standard Care on Clinical Worsening in Patients Hospitalized With #COVID-19 Pneumonia
#Hypoalbuminemia is associated with increased risk of acute #kidney injury in hospitalized patients: A meta-analysis
Highlights • Each 1.0 g/dL of serum albumin decrement was associated with increased odds of AKI (OR 1.685; 95% CI, 1.302–2.179). • The risk factors for AKI in hypoalbuminemic patients include 1) age ≥ 70 years and 2) baseline serum albumin level > 3.2 g/dL. • The association between hypoalbuminemia and overall mortality from AKI remained inconclusive as there was potential publication… Continue reading #Hypoalbuminemia is associated with increased risk of acute #kidney injury in hospitalized patients: A meta-analysis
2 Medical News 