Effect of liver steatosis on liver stiffness measurement in chronic hepatitis B patients with normal serum alanine aminotransferase levels: A multicentre cohort study

Liver steatosis is becoming increasingly common in patients with chronic hepatitis B (CHB), and its effect on liver stiffness measurement (LSM), as assessed by transient elastography, remains controversial. Seven hundred and fifty-five patients with CHB and normal serum alanine aminotransferase levels, who underwent vibration-controlled transient elastography and liver biopsy, were included in the study. We …

Continue reading Effect of liver steatosis on liver stiffness measurement in chronic hepatitis B patients with normal serum alanine aminotransferase levels: A multicentre cohort study

Food Insecurity is Associated with Mortality Among U.S. Adults with Nonalcoholic Fatty Liver Disease and Advanced Fibrosis

Food insecurity is a growing public health challenge in the U.S. and has been linked to nonalcoholic fatty liver disease (NAFLD) and advanced fibrosis. However, little is known of how food insecurity impacts mortality risk and healthcare utilization (HCU) in chronic liver disease. MethodsUsing a population-based cohort study of U.S. adults (≥20 years) in the …

Continue reading Food Insecurity is Associated with Mortality Among U.S. Adults with Nonalcoholic Fatty Liver Disease and Advanced Fibrosis

Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages

Highlights•Liver biopsies at stage F1 to F3 expressed more IL-22 than F0 or F4. •The number of cells expressing IL-22R1 decreased as fibrosis increased. •There was an increase in Il-22BP staining in more advanced stages of fibrosis. •IL-22 pathway may be involved in the pathophysiology of liver fibrosis. AbstractLiver fibrosis is the result of an …

Continue reading Liver expression of IL-22, IL-22R1 and IL-22BP in patients with chronic hepatitis C with different fibrosis stages

Plasma Levels of #Homocysteine is Associated with Liver #Fibrosis in Health Check-Up Population

Studies have shown a link between homocysteine (Hcy) and heart diseases, kidney diseases, cerebrovascular diseases, liver diseases, and other pathological conditions. However, the relationship between Hcy and liver fibrosis (LF) is unclear. Here, we studied the link between plasma Hcy concentration and LF. Methods: We determined and recorded the plasma Hcy concentration, general biochemical parameters, …

Continue reading Plasma Levels of #Homocysteine is Associated with Liver #Fibrosis in Health Check-Up Population

Immunotherapy-based targeting of MSLN+ activated portal #fibroblasts is a strategy for treatment of cholestatic liver #fibrosis

Mesothelin (Msln) expression is increased in tissue fibroblasts of damaged liver and other organs and Msln is a common mediator of liver, lung, and kidney fibrosis. We show that anti-Msln immunotoxins kill the Msln-expressing fibroblasts and reduce collagen type I deposition in fibrotic liver, indicating that agents that specifically kill Msln-expressing cells should be a …

Continue reading Immunotherapy-based targeting of MSLN+ activated portal #fibroblasts is a strategy for treatment of cholestatic liver #fibrosis