Estrogen receptor (ER) testing of breast cancer imperfectly predicts response to endocrine therapy (ET). We hypothesize that a brief estradiol challenge will increase tumor progesterone receptor (PgR) levels only in tumors with functional ER. In this prospective, phase 2, single-center, single-arm trial (NCT02455453), we report the association of response to ET with change in tumor… Continue reading Association of #PET-based #estradiol-challenge test for #breast cancer progesterone receptors with response to endocrine therapy
#Physical activity may not be associated with long‐term risk of #dementia and #Alzheimer’s disease
While it is well established that physical activity is associated with reduced risk of vascular and nonvascular outcomes as well as mortality, evidence on the association between physical activity and dementia is inconsistent. We aimed to assess the associations of physical activity with the risk of dementia and Alzheimer's disease (AD). Material and methods We… Continue reading #Physical activity may not be associated with long‐term risk of #dementia and #Alzheimer’s disease
#Hydrating the respiratory tract: an alternative explanation why masks lower severity of #COVID-19
The seasonality of respiratory diseases has been linked, among other factors, to low outdoor absolute humidity and low indoor relative humidity, which increase evaporation of water in the mucosal lining of the respiratory tract. We demonstrate that normal breathing results in an absorption-desorption cycle inside facemasks, in which supersaturated air is absorbed by the mask… Continue reading #Hydrating the respiratory tract: an alternative explanation why masks lower severity of #COVID-19
Association of #Gastric Bypass Surgery With Risk of Developing #Diabetic #Retinopathy Among Patients With #Obesity and Type 2 Diabetes in Sweden
Knowledge of the incidence and progression of diabetic retinopathy (DR) after gastric bypass surgery (GBP) in patients with obesity and diabetes could guide the management of these patients. Objective To investigate the incidence of diabetic ocular complications in patients with type 2 diabetes after GBP compared with the incidence of diabetic ocular complications in a… Continue reading Association of #Gastric Bypass Surgery With Risk of Developing #Diabetic #Retinopathy Among Patients With #Obesity and Type 2 Diabetes in Sweden
Early peripheral activity alters nascent subplate circuits in the #auditory cortex
Cortical function can be shaped by sensory experience during a critical period. The onset of the critical period is thought to coincide with the onset of thalamocortical transmission to the thalamo-recipient layer 4 (L4). In early development, subplate neurons (SPNs), and not L4 neurons, are the first targets of thalamic afferents. SPNs are transiently involved… Continue reading Early peripheral activity alters nascent subplate circuits in the #auditory cortex
NAD+ depletion by type I interferon signaling sensitizes #pancreatic cancer cells to NAMPT inhibition
Emerging evidence suggests that intratumoral interferon (IFN) signaling can trigger targetable vulnerabilities. A hallmark of pancreatic ductal adenocarcinoma (PDAC) is its extensively reprogrammed metabolic network, in which nicotinamide adenine dinucleotide (NAD) and its reduced form, NADH, are critical cofactors. Here, we show that IFN signaling, present in a subset of PDAC tumors, substantially lowers NAD(H)… Continue reading NAD+ depletion by type I interferon signaling sensitizes #pancreatic cancer cells to NAMPT inhibition
#Pain and fatigue are longitudinally and bi-directionally associated with more #sedentary time and less standing time in #rheumatoid arthritis
The aims of this study were to examine the longitudinal and bi-directional associations of pain and fatigue with sedentary, standing and stepping time in RA. Methods People living with RA undertook identical assessments at baseline (T1, n = 104) and 6-month follow-up (T2, n = 54). Participants completed physical measures (e.g. height, weight, BMI) and routine clinical assessments to… Continue reading #Pain and fatigue are longitudinally and bi-directionally associated with more #sedentary time and less standing time in #rheumatoid arthritis
Evaluation of Optimal #Diastolic Blood #Pressure Range Among Adults With Treated Systolic Blood Pressure Less Than 130 mm Hg
Extremely low diastolic blood pressure has been reported to be associated with increased adverse cardiovascular events (ie, the diastolic J-shape phenomenon); however, current US guidelines recommend an intensive blood pressure target of less than 130/80 mm Hg without mentioning the lower limits of diastolic blood pressure. Objectives To evaluate whether there is a diastolic J-shape… Continue reading Evaluation of Optimal #Diastolic Blood #Pressure Range Among Adults With Treated Systolic Blood Pressure Less Than 130 mm Hg
Post-traumatic growth during the #COVID-19 pandemic in carers of children in Portugal and the UK: cross-sectional online survey
Although the negative effects of the COVID-19 pandemic on mental health have attracted interest, little attention has focused on its positive effects and possible post-traumatic growth. Aims To assess anxiety, well-being and post-traumatic growth in carers of children aged 6–16 years in Portugal and the UK. Method A cross-sectional online survey of volunteers conducted at… Continue reading Post-traumatic growth during the #COVID-19 pandemic in carers of children in Portugal and the UK: cross-sectional online survey
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