Here we report on the antibody and memory B cell responses in a cohort of 20 volunteers who received either the Moderna (mRNA-1273) or Pfizer-BioNTech (BNT162b2) vaccines1–4. Eight weeks after the second vaccine injection volunteers showed high levels of IgM, and IgG anti-SARS-CoV-2 spike protein (S) and receptor binding domain (RBD) binding titers. Moreover, the… Continue reading #mRNA vaccine-elicited antibodies to #SARS-CoV-2 and circulating variants
Effect of High-Intensity Strength #Training on #Knee Pain and Knee Joint Compressive Forces Among Adults With Knee #Osteoarthritis
Thigh muscle weakness is associated with knee discomfort and osteoarthritis disease progression. Little is known about the efficacy of high-intensity strength training in patients with knee osteoarthritis or whether it may worsen knee symptoms. Objective To determine whether high-intensity strength training reduces knee pain and knee joint compressive forces more than low-intensity strength training and… Continue reading Effect of High-Intensity Strength #Training on #Knee Pain and Knee Joint Compressive Forces Among Adults With Knee #Osteoarthritis
Calculated indices of volatile organic compounds (VOCs) in exhalation for #lung #cancer screening and early detection
Breath analysis is a promising noninvasive technique that offers a wide range of opportunities to facilitate early diagnosis of lung cancer (LC). Method Exhaled breath samples of 352 subjects including 160 with lung cancer (LC), 70 with benign pulmonary nodule (BPN) and 122 healthy controls (HC) were analyzed through thermal desorption coupled with gas chromatography-mass… Continue reading Calculated indices of volatile organic compounds (VOCs) in exhalation for #lung #cancer screening and early detection
#SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801
All known recently emerged human coronaviruses probably originated in bats1. Here we used a single experimental platform based on human lung-only mice (LoM) to demonstrate efficient in vivo replication of all recently emerged human coronaviruses (SARS-CoV, MERS-CoV and SARS-CoV-2) and two highly relevant endogenous pre-pandemic SARS-like bat coronaviruses. Virus replication in this model occurs in… Continue reading #SARS-CoV-2 infection is effectively treated and prevented by EIDD-2801
#Antibiotic exposure during pregnancy and childhood #asthma: a national birth cohort study investigating timing of exposure and mode of delivery
...A total of 5522 (17%) children were born to mothers exposed to antibiotics during pregnancy. In adjusted analyses, children born to exposed mothers had higher odds of asthma (OR 1.14, 95% CI 1.05 to 1.24). There was no association with antibiotic exposure in the first trimester (OR 1.02, 95% CI 0.83 to 1.26), but higher… Continue reading #Antibiotic exposure during pregnancy and childhood #asthma: a national birth cohort study investigating timing of exposure and mode of delivery
An integrative study of five biological #clocks in somatic and mental #health
Biological clocks have been developed at different molecular levels and were found to be more advanced in the presence of somatic illness and mental disorders. However, it is unclear whether different biological clocks reflect similar aging processes and determinants. In ~3000 subjects, we examined whether five biological clocks (telomere length, epigenetic, transcriptomic, proteomic, and metabolomic… Continue reading An integrative study of five biological #clocks in somatic and mental #health
Risk of #Cardiovascular Disease Mortality in Relation to #Depression and 14 Common Risk Factors
Depression has been linked to a worse prognosis of Cardiovascular disease (CVD), and these two diseases share a variety of common risk factors such as unhealthy lifestyles and chronic medical conditions. However, the potential role of these common risk factors in modulating the association between depression and CVD mortality and whether the co-occurrence of depression… Continue reading Risk of #Cardiovascular Disease Mortality in Relation to #Depression and 14 Common Risk Factors
#Ticagrelor Added to #Aspirin in Acute Ischemic #Stroke or Transient Ischemic Attack in Prevention of Disabling Stroke A Randomized Clinical Trial
Reduction of subsequent disabling stroke is the main goal of preventive treatment in the acute setting after transient ischemic attack (TIA) or minor ischemic stroke. Objective To evaluate the superiority of ticagrelor added to aspirin in preventing disabling stroke and to understand the factors associated with recurrent disabling stroke. Design, Setting, and Participants The Acute… Continue reading #Ticagrelor Added to #Aspirin in Acute Ischemic #Stroke or Transient Ischemic Attack in Prevention of Disabling Stroke A Randomized Clinical Trial
Long-term risk of #stroke and myocardial #infarction in middle-aged men with a #hypertensive response to exercise: a 44-year follow-up study
Data on the prognostic value of hypertensive response to exercise in cardiovascular disease are limited. The aim was to determine whether SBP reactions during exercise have any prognostic value in relation to the long-term risk of stroke and myocardial infarction (MI). Patients and methods: A representative cohort of men from Gothenburg, Sweden, born in 1913,… Continue reading Long-term risk of #stroke and myocardial #infarction in middle-aged men with a #hypertensive response to exercise: a 44-year follow-up study
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