Our aim was to evaluate the safety and efficacy of a planned therapeutic withdrawal of all antihypertensive and diuretic medications, on commencing a formula low-energy diet replacement, targeting remission of type 2 diabetes. MethodsPost hoc analysis of changes in BP, antihypertensive medication prescriptions and symptoms during the initial total diet replacement phase was performed in… Continue reading #Antihypertensive medication needs and blood pressure control with weight loss in the #Diabetes Remission Clinical Trial (DiRECT)
Clinical characteristics and prognosis of patients with microvascular #angina: an international and prospective cohort study by the Coronary Vasomotor Disorders International Study (COVADIS) Group
To provide multi-national, multi-ethnic data on the clinical characteristics and prognosis of patients with microvascular angina (MVA). Methods and resultsThe Coronary Vasomotor Disorders International Study Group proposed the diagnostic criteria for MVA. We prospectively evaluated the clinical characteristics of patients according to these criteria and their prognosis. The primary endpoint was the composite of major… Continue reading Clinical characteristics and prognosis of patients with microvascular #angina: an international and prospective cohort study by the Coronary Vasomotor Disorders International Study (COVADIS) Group
Opportunistic Screening of Patients for Hepatic #Steatosis: Clinical Follow-Up and Diagnostic Yield
Hepatic steatosis is a common incidental finding on abdominal imaging that is not always reported or recognized as having clinical significance. Because of its association with liver disease, cirrhosis, and diabetes, the aim of this study was to bring attention to this finding and provide clinical guidance to referring clinicians by inserting standardized text into… Continue reading Opportunistic Screening of Patients for Hepatic #Steatosis: Clinical Follow-Up and Diagnostic Yield
Effect of Extended-Release #Naltrexone on #Alcohol Consumption: A Systematic Review and Meta-analysis
Aims1) Estimate the effect of extended-release naltrexone compared with placebo on alcohol consumption in patients with alcohol use disorder (AUD). 2) Conduct pre-planned subgroup analyses to test whether being abstinent when initiating treatment (lead-in abstinence) or the duration of treatment improves treatment efficacy. DesignSystematic review and random effects meta-analysis of blinded randomized placebo-controlled trials reporting… Continue reading Effect of Extended-Release #Naltrexone on #Alcohol Consumption: A Systematic Review and Meta-analysis
Randomized Manipulation of Early #Cognitive Experience Impacts Adult Brain Structure
Does early exposure to cognitive and linguistic stimulation impact brain structure? Or do genetic predispositions account for the co-occurrence of certain neuroanatomical phenotypes and a tendency to engage children in cognitively stimulating activities? Low socioeconomic status infants were randomized to either 5 years of cognitively and linguistically stimulating center-based care or a comparison condition. The… Continue reading Randomized Manipulation of Early #Cognitive Experience Impacts Adult Brain Structure
Causal Effect of #Tooth Loss on Functional Capacity in Older Adults in England: A Natural Experiment
Background/ObjectivesTooth loss is associated with reduced functional capacity, but so far, there is no relevant causal evidence reported. We investigated the causal effect of tooth loss on the instrumental activities of daily living (IADL) among older adults in England. DesignNatural experiment study with instrumental variable analysis. SettingThe English Longitudinal Study of Aging (ELSA) combined with… Continue reading Causal Effect of #Tooth Loss on Functional Capacity in Older Adults in England: A Natural Experiment
Increased #Risk of Stroke in Patients With #Obsessive-Compulsive Disorder: A Nationwide Longitudinal Study
Patients with obsessive-compulsive disorder (OCD) tend to be comorbid with stroke-related risk factors, including obesity, hypertension, and diabetes. However, the temporal association between OCD and subsequent stroke risk is unclear. Methods:Using data collected between 2001 and 2010 by Taiwan’s National Health Insurance Research Database, 28 064 adult patients with OCD (International Classification of Diseases, Ninth… Continue reading Increased #Risk of Stroke in Patients With #Obsessive-Compulsive Disorder: A Nationwide Longitudinal Study
Genetically Proxied Diurnal Preference, #Sleep Timing, and Risk of Major #Depressive Disorder
Morning diurnal preference is associated with reduced risk of major depressive disorder (MDD); however, causality in this association is uncertain. Objective To examine the association of genetically proxied morning diurnal preference with depression risk using mendelian randomization. Design, Setting, and Participants This 2-sample mendelian randomization study used summary-level genetic associations with diurnal preference and MDD.… Continue reading Genetically Proxied Diurnal Preference, #Sleep Timing, and Risk of Major #Depressive Disorder
#Mirtazapine in cancer-associated #anorexia and #cachexia: A double-blind placebo-controlled randomized trial
Few pharmacological interventions are available for cancer-associated anorexia and cachexia. Mirtazapine has been suggested for use in cancer-associated anorexia and cachexia. ObjectivesThis study was conducted to assess the efficacy and tolerability of mirtazapine in cancer-associated anorexia and cachexia. MethodsA double-blind placebo-controlled randomized trial. The study included 120 incurable solid tumour patients with anorexia (appetite loss… Continue reading #Mirtazapine in cancer-associated #anorexia and #cachexia: A double-blind placebo-controlled randomized trial
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