HighlightsSerum gut-permeability markers LPB, LPS, and I-FABP are increased in RAMice with arthritis have increased gut permeability and intestinal inflammationBoth bacteria and leukocytes are needed to disrupt gut-barrier integrityPrevention of gut-barrier dysfunction in arthritis ameliorates joint inflammation Context and significanceRheumatoid arthritis is an autoimmune disorder characterized by chronic joint inflammation. Accumulating evidence suggests that changes… Continue reading #Intestinal barrier dysfunction plays an integral role in #arthritis pathology and can be targeted to ameliorate disease
Vitamin #C and scar strength: analysis of a historical trial and implications for #collagen-related pathologies
A double-blind controlled trial initiated in 1944 has led to the common narrative that a 10-mg daily vitamin C intake is adequate to prevent and treat impaired wound healing, and by inference, other collagen-related diseases such as heart disease or stroke. The WHO relies on this narrative to set the recommended nutrient intake for vitamin… Continue reading Vitamin #C and scar strength: analysis of a historical trial and implications for #collagen-related pathologies
The effectiveness and safety of isometric #resistance training for adults with high blood #pressure: a systematic review and meta-analysis
High blood pressure (BP) is a global health challenge. Isometric resistance training (IRT) has demonstrated antihypertensive effects, but safety data are not available, thereby limiting its recommendation for clinical use. We conducted a systematic review of randomized controlled trials comparing IRT to controls in adults with elevated BP (systolic ≥130 mmHg/diastolic ≥85 mmHg). This review provides an… Continue reading The effectiveness and safety of isometric #resistance training for adults with high blood #pressure: a systematic review and meta-analysis
Plasma Levels of #Homocysteine is Associated with Liver #Fibrosis in Health Check-Up Population
Studies have shown a link between homocysteine (Hcy) and heart diseases, kidney diseases, cerebrovascular diseases, liver diseases, and other pathological conditions. However, the relationship between Hcy and liver fibrosis (LF) is unclear. Here, we studied the link between plasma Hcy concentration and LF. Methods: We determined and recorded the plasma Hcy concentration, general biochemical parameters,… Continue reading Plasma Levels of #Homocysteine is Associated with Liver #Fibrosis in Health Check-Up Population
#Edoxaban versus Vitamin K Antagonist for Atrial #Fibrillation after #TAVR
The role of direct oral anticoagulants as compared with vitamin K antagonists for atrial fibrillation after successful transcatheter aortic-valve replacement (TAVR) has not been well studied. METHODSWe conducted a multicenter, prospective, randomized, open-label, adjudicator-masked trial comparing edoxaban with vitamin K antagonists in patients with prevalent or incident atrial fibrillation as the indication for oral anticoagulation… Continue reading #Edoxaban versus Vitamin K Antagonist for Atrial #Fibrillation after #TAVR
#COVID-19 Transmission Dynamics Among Close #Contacts of Index Patients With COVID-19A Population-Based Cohort Study in Zhejiang Province, China
Much remains unknown about the transmission dynamics of COVID-19. How the severity of the index case and timing of exposure is associated with disease in close contacts of index patients with COVID-19 and clinical presentation in those developing disease is not well elucidated. Objectives To investigate the association between the timing of exposure and development… Continue reading #COVID-19 Transmission Dynamics Among Close #Contacts of Index Patients With COVID-19A Population-Based Cohort Study in Zhejiang Province, China
Limited protection against #SARS-CoV-2 infection and virus transmission after mRNA #vaccination
Stang and coworkers have recently reported in the Journal that “RT-PCR test results as gold standard for assessing and controlling infectiousness fail”[1]. The authors analyzed two scenarios and used Ct25 and Ct30 as thresholds for infectiousness and conclude that more than the half of their patient cohort was unlikely to have been infectious, i.e. the… Continue reading Limited protection against #SARS-CoV-2 infection and virus transmission after mRNA #vaccination
Pilot randomized controlled trial of a #hypnosis intervention for women with #bladder pain syndrome
To evaluate the feasibility and acceptability of a randomized controlled trial of a hypnosis intervention for the treatment of bladder pain syndrome/interstitial cystitis (BPS/IC) in women. MethodsWe conducted a parallel arm, non-blinded, pilot randomized controlled trial of standardized hypnosis sessions including a hypnosis web tool versus usual care in adult women with BPS/IC. Pilot study… Continue reading Pilot randomized controlled trial of a #hypnosis intervention for women with #bladder pain syndrome
Association of poor #housing conditions with #COVID-19 incidence and mortality across US counties
Poor housing conditions have been linked with worse health outcomes and infectious disease spread. Since the relationship of poor housing conditions with incidence and mortality of COVID-19 is unknown, we investigated the association between poor housing condition and COVID-19 incidence and mortality in US counties. MethodsWe conducted cross-sectional analysis of county-level data from the US… Continue reading Association of poor #housing conditions with #COVID-19 incidence and mortality across US counties
2 Medical News 