Postpartum depression (PPD) is one of the most common medicalcomplications during and after pregnancy, negatively affecting both mother and child.OBJECTIVE To demonstrate the efficacy and safety of zuranolone, a neuroactive steroidγ-aminobutyric acid receptor–positive allosteric modulator, in PPD. DESIGN, SETTING, AND PARTICIPANTS This phase 3, double-blind, randomized, outpatient,placebo-controlled clinical trial was conducted between January 2017 and… Continue reading Effect of #Zuranolone vs Placebo in Postpartum #DepressionA Randomized Clinical Trial
Association of #Cycling With All-Cause and #Cardiovascular Disease Mortality Among Persons With #DiabetesThe European Prospective Investigation Into Cancer and Nutrition (EPIC) Study
Premature death from all causes and cardiovascular disease (CVD) causes is higher among persons with diabetes. Objective To investigate the association between time spent cycling and all-cause and CVD mortality among persons with diabetes, as well as to evaluate the association between change in time spent cycling and risk of all-cause and CVD mortality. Design,… Continue reading Association of #Cycling With All-Cause and #Cardiovascular Disease Mortality Among Persons With #DiabetesThe European Prospective Investigation Into Cancer and Nutrition (EPIC) Study
Observing changes in human functioning during induced #sleep deficiency and recovery periods
Prolonged periods of sleep restriction seem to be common in the contemporary world. Sleep loss causes perturbations of circadian rhythmicity and degradation of waking alertness as reflected in attention, cognitive efficiency and memory. Understanding whether and how the human brain recovers from chronic sleep loss is important not only from a scientific but also from… Continue reading Observing changes in human functioning during induced #sleep deficiency and recovery periods
#Metoprolol in Critically Ill Patients With COVID-19
Severe coronavirus disease-2019 (COVID-19) can progress to an acute respiratory distress syndrome (ARDS), which involves alveolar infiltration by activated neutrophils. The beta-blocker metoprolol has been shown to ameliorate exacerbated inflammation in the myocardial infarction setting. ObjectivesThe purpose of this study was to evaluate the effects of metoprolol on alveolar inflammation and on respiratory function in… Continue reading #Metoprolol in Critically Ill Patients With COVID-19
#Steps per Day and All-Cause #Mortality in Middle-aged Adultsin the Coronary Artery Risk Development in Young Adults Study
IMPORTANCE Steps per day is a meaningful metric for physical activity promotion in clinical andpopulation settings. To guide promotion strategies of step goals, it is important to understand theassociation of steps with clinical end points, including mortality. OBJECTIVE To estimate the association of steps per day with premature (age 41-65 years) all-causemortality among Black and… Continue reading #Steps per Day and All-Cause #Mortality in Middle-aged Adultsin the Coronary Artery Risk Development in Young Adults Study
Two Phase 3 Trials of Inclisiran in Patients with Elevated #LDL Cholesterol
Inclisiran inhibits hepatic synthesis of proprotein convertase subtilisin–kexin type 9. Previous studies suggest that inclisiran might provide sustained reductions in low-density lipoprotein (LDL) cholesterol levels with infrequent dosing. METHODSWe enrolled patients with atherosclerotic cardiovascular disease (ORION-10 trial) and patients with atherosclerotic cardiovascular disease or an atherosclerotic cardiovascular disease risk equivalent (ORION-11 trial) who had elevated… Continue reading Two Phase 3 Trials of Inclisiran in Patients with Elevated #LDL Cholesterol
#Ivermectin for Prevention and Treatment of #COVID-19Infection: A Systematic Review, Meta-analysis, and TrialSequential Analysis to Inform Clinical Guidelines
Background: Repurposed medicines may have a role against the SARS-CoV-2 virus. The antiparasiticivermectin, with antiviral and anti-inflammatory properties, has now been tested in numerous clinical trials. Areas of uncertainty: We assessed the efficacy of ivermectin treatment in reducing mortality, in secondary outcomes, and in chemoprophylaxis, among people with, or at high risk of, COVID-19 infection.… Continue reading #Ivermectin for Prevention and Treatment of #COVID-19Infection: A Systematic Review, Meta-analysis, and TrialSequential Analysis to Inform Clinical Guidelines
#Intestinal barrier dysfunction plays an integral role in #arthritis pathology and can be targeted to ameliorate disease
HighlightsSerum gut-permeability markers LPB, LPS, and I-FABP are increased in RAMice with arthritis have increased gut permeability and intestinal inflammationBoth bacteria and leukocytes are needed to disrupt gut-barrier integrityPrevention of gut-barrier dysfunction in arthritis ameliorates joint inflammation Context and significanceRheumatoid arthritis is an autoimmune disorder characterized by chronic joint inflammation. Accumulating evidence suggests that changes… Continue reading #Intestinal barrier dysfunction plays an integral role in #arthritis pathology and can be targeted to ameliorate disease
Vitamin #C and scar strength: analysis of a historical trial and implications for #collagen-related pathologies
A double-blind controlled trial initiated in 1944 has led to the common narrative that a 10-mg daily vitamin C intake is adequate to prevent and treat impaired wound healing, and by inference, other collagen-related diseases such as heart disease or stroke. The WHO relies on this narrative to set the recommended nutrient intake for vitamin… Continue reading Vitamin #C and scar strength: analysis of a historical trial and implications for #collagen-related pathologies
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