Recently, topical Tranexamic acid (TXA) has been used in melasma management. On detail search of literature, this may be the first study assessing efficacy on combining of Topical TXA with GA peel in melasma. To assess efficacy, safety and improvement in quality of life index on combining 30% GA peel with 5% TXA solution topically… Continue reading Topical 5% #Tranexamic acid with 30% #Glycolic acid peel: An useful Combination for Accelerating the improvement in #Melasma
First #monoclonal antibody treatment for #COVID-19 approved for use in the UK
Following on from a thorough review of the evidence carried out by the MHRA, and recommendation by the Commission on Human Medicines (CHM), the government’s independent expert scientific advisory body, the MHRA has approved Ronapreve as the first monoclonal antibody combination product indicated for use in the prevention and treatment of acute COVID-19 infection for… Continue reading First #monoclonal antibody treatment for #COVID-19 approved for use in the UK
Enteric-Coated #Aspirin and the Risk of Gastrointestinal Side Effects: A Systematic Review
Aspirin appeared as a medicine to deal with aches and inflammation, but due to its antiplatelet properties, it has evolved into a drug mainly used to avert cardiovascular disease. Regardless of its therapeutic uses, the limiting aspect for aspirin use has been its affiliation with gastrointestinal (GI) toxicity, classifying from acute mucosal damage to GI… Continue reading Enteric-Coated #Aspirin and the Risk of Gastrointestinal Side Effects: A Systematic Review
Microbial Diversity and Abundance of Parabacteroides Mediate the Associations Between Higher Intake of #Flavonoid-Rich Foods and Lower Blood #Pressure
We assessed, for the first time, to what extent the composition of the gut microbiome might explain the cross-sectional association of habitual flavonoid and flavonoid-rich food intake with systolic and diastolic blood pressure (BP) in a community-based sample (N=904) from Northern Germany. Gut microbiome composition was sequenced from 16S ribosomal RNA genes. Higher total flavonoid… Continue reading Microbial Diversity and Abundance of Parabacteroides Mediate the Associations Between Higher Intake of #Flavonoid-Rich Foods and Lower Blood #Pressure
#Cognitive stimulation in the workplace, plasma proteins, and risk of #dementia: three analyses of population cohort studies
To examine the association between cognitively stimulating work and subsequent risk of dementia and to identify protein pathways for this association. Design Multicohort study with three sets of analyses. Setting United Kingdom, Europe, and the United States. Participants Three associations were examined: cognitive stimulation and dementia risk in 107 896 participants from seven population based prospective… Continue reading #Cognitive stimulation in the workplace, plasma proteins, and risk of #dementia: three analyses of population cohort studies
The association between occupational #asbestos exposure with the risk of incidence and mortality from #prostate #cancer: a systematic review and meta-analysis
There is conflicting evidence on the association between asbestos exposure and prostate cancer (PCa). Two recent meta-analyses have claimed that exposure is associated with increased PCa incidence and mortality, but they suffer from some methodological flaws. Given the potential importance of this research question, we aimed to perform a methodologically sound systematic review and meta-analysis… Continue reading The association between occupational #asbestos exposure with the risk of incidence and mortality from #prostate #cancer: a systematic review and meta-analysis
Blood #pressure visit-to-visit variability and outcomes in patients with #heart failure with preserved ejection fraction
Previous studies report that blood pressure (BP) variability is associated with increased risk of adverse outcomes in patients diagnosed with cardiovascular disease. However, studies have not fully explored this association in patients with heart failure with preserved ejection fraction (HFpEF). This study sought to explore the association between visit-to-visit variability (VVV) of BP and clinical… Continue reading Blood #pressure visit-to-visit variability and outcomes in patients with #heart failure with preserved ejection fraction
Evidence of a Causal Relationship between Serum #Thyroid-Stimulating Hormone and #Osteoporotic Bone Fractures
We aimed to validate the association of genome-wide association study (GWAS)-identified loci and polygenic risk score with serum thyroid-stimulating hormone (TSH) concentrations and the diagnosis of hypothyroidism. Then, the causal relationship between serum TSH and osteoporotic bone fracture risk was tested. Methods: A cross-sectional study was done among patients of European Caucasian ethnicity recruited in… Continue reading Evidence of a Causal Relationship between Serum #Thyroid-Stimulating Hormone and #Osteoporotic Bone Fractures
Daily #energy expenditure through the human life course
Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95… Continue reading Daily #energy expenditure through the human life course
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