We propose a weight-neutral strategy for obesity treatment on the following grounds: (1) the mortality risk associated with obesity is largely attenuated or eliminated by moderate-to-high levels of cardiorespiratory fitness (CRF) or physical activity (PA), (2) most cardiometabolic risk markers associated with obesity can be improved with exercise training independent of weight loss and by… Continue reading #Obesity treatment: #Weight loss versus increasing #fitness and physical activity for reducing health risks
Computational drug repositioning of #atorvastatin for ulcerative #colitis
Ulcerative colitis (UC) is a chronic inflammatory disorder with limited effective therapeutic options for long-term treatment and disease maintenance. We hypothesized that a multi-cohort analysis of independent cohorts representing real-world heterogeneity of UC would identify a robust transcriptomic signature to improve identification of FDA-approved drugs that can be repurposed to treat patients with UC. Materials… Continue reading Computational drug repositioning of #atorvastatin for ulcerative #colitis
Baseline #Gut Metagenomic Functional Gene Signature Associated with Variable #Weight Loss Responses following a Healthy Lifestyle Intervention in Humans
Recent human feeding studies have shown how the baseline taxonomic composition of the gut microbiome can determine responses to weight loss interventions. However, the functional determinants underlying this phenomenon remain unclear. We report a weight loss response analysis on a cohort of 105 individuals selected from a larger population enrolled in a commercial wellness program,… Continue reading Baseline #Gut Metagenomic Functional Gene Signature Associated with Variable #Weight Loss Responses following a Healthy Lifestyle Intervention in Humans
Prevalence and Associated Diseases of #Seborrheic Skin in Adults
Seborrhea is a skin condition characterized by abundant production of sebum associated with typical dermatological conditions such as rosacea and acne. Little is known about the prevalence of seborrhea and the frequency of concurrent skin diseases in the general population. Objective: To investigate the epidemiology and comorbidity of seborrhea in the adolescent and adult working… Continue reading Prevalence and Associated Diseases of #Seborrheic Skin in Adults
Analysis of Features of #Alzheimer’s Disease: Detection of Early Stage from Functional Brain Changes in Magnetic #Resonance Images Using a Finetuned ResNet18 Network
One of the first signs of Alzheimer’s disease (AD) is mild cognitive impairment (MCI), in which there are small variants of brain changes among the intermediate stages. Although there has been an increase in research into the diagnosis of AD in its early levels of developments lately, brain changes, and their complexity for functional magnetic… Continue reading Analysis of Features of #Alzheimer’s Disease: Detection of Early Stage from Functional Brain Changes in Magnetic #Resonance Images Using a Finetuned ResNet18 Network
#Metabolic Syndrome, and Not #Obesity, Is Associated with Chronic #Kidney Disease
Obese (OB) patients are at increased risk of chronic kidney disease, but it is still unclear whether this can be attributed to obesity per se or to the associated metabolic derangements. The aim of this study was to evaluate the relative impact of obesity and metabolic syndrome (MS) on kidney disease. Methods: This is a… Continue reading #Metabolic Syndrome, and Not #Obesity, Is Associated with Chronic #Kidney Disease
#Elastography is unable to exclude #cirrhosis after sustained virological response in #HCV-infected patients with advanced chronic liver disease
Liver fibrosis and transient elastography (TE) correlation in hepatitis C virus (HCV)-infected patients with compensated advanced chronic liver disease (cACLD) after sustained virological response (SVR) is unknown. AimsTo evaluate TE accuracy at identifying cirrhosis 3 years after HCV-eradication. MethodsProspective, multi-centric study including HCV-cACLD patients before direct-acting antivirals (DAA). Diagnostic accuracy of TE (area under ROC,… Continue reading #Elastography is unable to exclude #cirrhosis after sustained virological response in #HCV-infected patients with advanced chronic liver disease
BNT162b2 vaccine breakthrough: clinical characteristics of 152 fully #vaccinated hospitalized #COVID-19 patients in Israel
The mRNA coronavirus disease 2019 (COVID-19) vaccines have shown high effectiveness in the prevention of symptomatic COVID-19, hospitalization, severe disease and death. Nevertheless, a minority of vaccinated individuals might become infected and experience significant morbidity. Characteristics of vaccine breakthrough infections have not been studied. We sought to portray the population of Israeli patients, who were… Continue reading BNT162b2 vaccine breakthrough: clinical characteristics of 152 fully #vaccinated hospitalized #COVID-19 patients in Israel
Associations of #ophthalmic and systemic conditions with incident #dementia in the UK Biobank
To examine independent and interactive associations of ophthalmic and systemic conditions with incident dementia. Methods: Our analysis included 12 364 adults aged 55-73 years from the UK Biobank cohort. Participants were assessed between 2006 and 2010 at baseline and were followed up until the early of 2021. Incident dementia was ascertained using hospital inpatient, death… Continue reading Associations of #ophthalmic and systemic conditions with incident #dementia in the UK Biobank
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