Prostate cancer (PCa) is a heterogenous disease with multiple etiological factors playing a role in its development. Recently, chronic and systemic inflammatory conditions such as inflammatory bowel disease were identified as key risk factors influencing its development. The study aimed to evaluate the relationship between diverticular disease (DD) (local and acute inflammation) and PCa. MethodsHypertensive… Continue reading Impact of #diverticular disease on #prostate cancer risk among #hypertensive men
Effects of #SGLT-2 inhibitors on serum #uric acid in patients with T2DM: A systematic review and network meta-analysis
The present study aims to determine the effects of sodium-glucose cotransporter 2 (SGLT-2) inhibitors on the serum uric acid (SUA) levels of patients with type 2 diabetes mellitus (T2DM) in Asia. MethodsPubMed, CENTRAL, Embase and Cochrane Library databases were searched for randomized controlled trials (RCTs) of SGLT-2 inhibitors in patients with T2DM up to July… Continue reading Effects of #SGLT-2 inhibitors on serum #uric acid in patients with T2DM: A systematic review and network meta-analysis
Total #sleep deprivation reduces top-down regulation of #emotion without altering bottom-up affective processing
Sleep loss is reported to influence affective processing, causing changes in overall mood and altering emotion regulation. These aspects of affective processing are seldom investigated together, making it difficult to determine whether total sleep deprivation has a global effect on how affective stimuli and emotions are processed, or whether specific components of affective processing are… Continue reading Total #sleep deprivation reduces top-down regulation of #emotion without altering bottom-up affective processing
The recurrence rate of #Helicobacter pylori in recent 10 years: A systematic review and meta-analysis
To update and evaluate the recurrence rate of Helicobacter pylori (H. pylori) eradication therapy in recent 10 years. MethodsA systematic search of PubMed, Embase, Cochrane library, and Web of science was performed to identify the studies of recurrence rate of H. pylori published from 2010 to 2019. Stata 15.0 was used for analysis. ResultsA total… Continue reading The recurrence rate of #Helicobacter pylori in recent 10 years: A systematic review and meta-analysis
#Proteinuria as a Significant Predictive Factor for the Progression of Carotid Artery #Atherosclerosis in Non-Albuminuric Type 2 #Diabetes
The purpose of this study was to evaluate whether the urine protein to creatinine ratio (uPCR) has have clinical significance in relation to cardiovascular risk associated with carotid artery intima-media thickness (cIMT) progression, in subjects with type 2 diabetes and normoalbuminuria. MethodsIn this retrospective longitudinal study on T2D, we recruited 927 subjects with normoalbuminuria (urine… Continue reading #Proteinuria as a Significant Predictive Factor for the Progression of Carotid Artery #Atherosclerosis in Non-Albuminuric Type 2 #Diabetes
Effect of Long-Term Marine #Omega-3 Fatty Acids Supplementation on the Risk of Atrial #Fibrillation in Randomized Controlled Trials of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
Some, but not all, large-scale randomized controlled trials (RCTs) investigating the effects of marine omega-3 fatty acids supplementation on cardiovascular outcomes have reported increased risks of atrial fibrillation (AF). The potential reasons for disparate findings may be dose related. Methods: The MEDLINE and Embase databases were searched for articles and abstracts published between January 1,… Continue reading Effect of Long-Term Marine #Omega-3 Fatty Acids Supplementation on the Risk of Atrial #Fibrillation in Randomized Controlled Trials of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis
Adjunctive #dietary intervention for #bipolar disorder: a randomized, controlled, parallel-group, modified double-blinded trial of a high n-3 plus low n-6 diet
To investigate the preliminary efficacy of a high n-3 plus low n-6 (H3-L6) dietary intervention in improving mood stability in Bipolar Disorder (BD) when compared to dietary intervention with usual U.S. levels of n-6 and n-3 polyunsaturated fatty acid (PUFA) intakes (control diet, CD). MethodsThis 2-arm, parallel-group, randomized, modified double-blind, controlled 48-week study of 12-week… Continue reading Adjunctive #dietary intervention for #bipolar disorder: a randomized, controlled, parallel-group, modified double-blinded trial of a high n-3 plus low n-6 diet
Optimal Blood #Pressure Keeps Our #Brains Younger
Elevated blood pressure (BP) is a major health risk factor and the leading global cause of premature death. Hypertension is also a risk factor for cognitive decline and dementia. However, when elevated blood pressure starts impacting cerebral health is less clear. We addressed this gap by estimating how a validated measure of brain health relates… Continue reading Optimal Blood #Pressure Keeps Our #Brains Younger
Association of #Statin Therapy Initiation With #Diabetes ProgressionA Retrospective Matched-Cohort Study
Statin therapy has been associated with increased insulin resistance; however, its clinical implications for diabetes control among patients with diabetes is unknown. Objective To assess diabetes progression after initiation of statin use in patients with diabetes. Design, Setting, and Participants This was a retrospective matched-cohort study using new-user and active-comparator designs to assess associations between… Continue reading Association of #Statin Therapy Initiation With #Diabetes ProgressionA Retrospective Matched-Cohort Study
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