#Probiotic Properties of #Escherichia coli Nissle in Human Intestinal Organoids

Probiotic, or beneficial, bacteria, such as E. coli Nissle, hold promise for the treatment of human disease. More study is needed to fully realize the potential of probiotics. Safety and efficacy studies are critically important; however, mice are poor models for many human intestinal diseases. We used stem cell-derived human intestinal organoid tissues to evaluate the safety of Nissle and its ability to protect from … Continue reading #Probiotic Properties of #Escherichia coli Nissle in Human Intestinal Organoids

Food & mood: a review of supplementary prebiotic and probiotic interventions in the treatment of anxiety and depression in adult

A bidirectional relationship exists between the brain and the gastrointestinal tract. Foods containing bacteria that positively influence the gastrointestinal microbiome are termed, probiotics; compounds that promote the flourishing of these bacteria are termed, prebiotics. Whether microbiome influencing therapies could treat psychiatric conditions, including depression and anxiety, is an area of interest. Presently, no established consensus for such treatment exists.. .. 7 studies were identified. All … Continue reading Food & mood: a review of supplementary prebiotic and probiotic interventions in the treatment of anxiety and depression in adult

Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans

Recent discoveries have implicated the gut #microbiome in the progression and severity of #Parkinson’s disease; however, how gut bacteria affect such neurodegenerative disorders remains unclear. Here, we report that the Bacillus subtilis probiotic strain PXN21 inhibits α-synuclein aggregation and clears preformed aggregates in an established Caenorhabditis elegans model of synucleinopathy. This protection is seen in young and aging animals and is partly mediated by DAF-16. … Continue reading Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans