Statin therapy has been associated with increased insulin resistance; however, its clinical implications for diabetes control among patients with diabetes is unknown. Objective To assess diabetes progression after initiation of statin use in patients with diabetes. Design, Setting, and Participants This was a retrospective matched-cohort study using new-user and active-comparator designs to assess associations between… Continue reading Association of #Statin Therapy Initiation With #Diabetes ProgressionA Retrospective Matched-Cohort Study
Biomarkers of #dairy #fat intake, incident #cardiovascular disease, and all-cause mortality: A cohort study, systematic review, and meta-analysis
We aimed to investigate the association of serum pentadecanoic acid (15:0), a biomarker of dairy fat intake, with incident cardiovascular disease (CVD) and all-cause mortality in a Swedish cohort study. We also systematically reviewed studies of the association of dairy fat biomarkers (circulating or adipose tissue levels of 15:0, heptadecanoic acid [17:0], and trans-palmitoleic acid… Continue reading Biomarkers of #dairy #fat intake, incident #cardiovascular disease, and all-cause mortality: A cohort study, systematic review, and meta-analysis
#Nafamostat–Interferon-α Combination Suppresses SARS-CoV-2 Infection In Vitro and In Vivo by Cooperatively Targeting Host TMPRSS2
SARS-CoV-2 and its vaccine/immune-escaping variants continue to pose a serious threat to public health due to a paucity of effective, rapidly deployable, and widely available treatments. Here, we address these challenges by combining Pegasys (IFNα) and nafamostat to effectively suppress SARS-CoV-2 infection in cell culture and hamsters. Our results indicate that Serpin E1 is an… Continue reading #Nafamostat–Interferon-α Combination Suppresses SARS-CoV-2 Infection In Vitro and In Vivo by Cooperatively Targeting Host TMPRSS2
Long‐Term Exposure to Air #Pollution, Road #Traffic Noise, and #Heart Failure Incidence: The Danish Nurse Cohort
We examined the association of long‐term exposure to air pollution and road traffic noise with incident heart failure (HF). Methods And ResultsUsing data on female nurses from the Danish Nurse Cohort (aged >44 years), we investigated associations between 3‐year mean exposures to air pollution and road traffic noise and incident HF using Cox regression models,… Continue reading Long‐Term Exposure to Air #Pollution, Road #Traffic Noise, and #Heart Failure Incidence: The Danish Nurse Cohort
Effectiveness of #mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: a retrospective cohort study
Vaccine effectiveness studies have not differentiated the effect of the delta (B.1.617.2) variant and potential waning immunity in observed reductions in effectiveness against SARS-CoV-2 infections. We aimed to evaluate overall and variant-specific effectiveness of BNT162b2 (tozinameran, Pfizer–BioNTech) against SARS-CoV-2 infections and COVID-19-related hospital admissions by time since vaccination among members of a large US health-care… Continue reading Effectiveness of #mRNA BNT162b2 COVID-19 vaccine up to 6 months in a large integrated health system in the USA: a retrospective cohort study
A “Proof of Concept” Randomized Controlled Trial of a Video Game Requiring Emotional Regulation to Augment #Anger Control Training
Emotional dysregulation leading to clinically significant anger and aggression is a common and substantial concern for youth and their families. While psychotropic medications and cognitive behavioral therapies can be effective, these modalities suffer from drawbacks such as significant side effects, high rates of attrition, and lack of real-world skill translation. Regulate and Gain Emotional Control… Continue reading A “Proof of Concept” Randomized Controlled Trial of a Video Game Requiring Emotional Regulation to Augment #Anger Control Training
#Depressive Symptoms Imputed Across the Life Course Are Associated with #Cognitive Impairment and Cognitive Decline
Depressive symptoms may increase risk for dementia, but findings are controversial because late-life depression may be a prodromal dementia symptom. Life course data on depression and dementia risk may clarify this association; however, data is limited. Objective: To impute adult depressive symptoms trajectories across adult life stages and estimate the association with cognitive impairment and… Continue reading #Depressive Symptoms Imputed Across the Life Course Are Associated with #Cognitive Impairment and Cognitive Decline
#Bone mineral density and bone turnover ten years after a single 5mg dose or two 5-yearly lower doses of #zoledronate in osteopenic older women: an open-label extension of a randomized controlled trial
Intravenous zoledronate reduces fracture risk (5mg at 18mo intervals) and prevents bone loss (doses of 1-5mg for 3 to >5y), but the duration of action of a single 5mg dose and the effects of lower doses beyond 5 years are unknown. We report the second open-label extension (years 5-10) of a 2y randomized, multidose, placebo-controlled, double-blinded… Continue reading #Bone mineral density and bone turnover ten years after a single 5mg dose or two 5-yearly lower doses of #zoledronate in osteopenic older women: an open-label extension of a randomized controlled trial
ADAMTSL2 protein and a soluble biomarker signature identify significant and advanced #fibrosis in adults with #NAFLD
Using an aptamer-based profiling platform we identified an individual and panel of circulating proteins that non-invasively identify significant fibrosis at-risk NASH in 316 adults with NAFLD.•An 8-protein panel can distinguish NAFL/NASH fibrosis stage 0-1 from fibrosis stage 2-4 with an AUROC 0.87- 0.89.•The ADAMTSL2 protein alone can distinguish NAFL/NASH fibrosis stage 0-1 from fibrosis stage… Continue reading ADAMTSL2 protein and a soluble biomarker signature identify significant and advanced #fibrosis in adults with #NAFLD
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