Respiratory fluoroquinolone antibiotics are some of the most common medications with QT interval–prolonging potential prescribed to patients with hemodialysis-dependent kidney failure—individuals who have a very high risk of sudden cardiac death (SCD). To date, there have been no large-scale, population-specific studies evaluating the cardiac safety of respiratory fluoroquinolones in the hemodialysis population. Objective To investigate… Continue reading Analysis of Respiratory #Fluoroquinolones and the Risk of Sudden #Cardiac Death Among Patients Receiving #Hemodialysis
#Nut consumption in association with overall mortality and recurrence/disease-specific mortality among long-term breast #cancer survivors
High nut consumption is associated with reduced total and certain cause-specific mortality in general populations. However, its association with cancer outcomes among long-term breast cancer survivors remains unknown. We examined the associations of nut consumption (including peanuts and tree nuts), assessed at 5-year postdiagnosis, with overall survival (OS) and disease-free survival (DFS) among 3449 long-term… Continue reading #Nut consumption in association with overall mortality and recurrence/disease-specific mortality among long-term breast #cancer survivors
#GLUT4-overexpressing engineered muscle constructs as a therapeutic platform to normalize #glycemia in diabetic mice
Skeletal muscle insulin resistance is a main defect in type 2 diabetes (T2D), which is associated with impaired function and content of glucose transporter type 4 (GLUT4). GLUT4 overexpression in skeletal muscle tissue can improve glucose homeostasis. Therefore, we created an engineered muscle construct (EMC) composed of GLUT4-overexpressing (OEG4) cells. The ability of the engineered… Continue reading #GLUT4-overexpressing engineered muscle constructs as a therapeutic platform to normalize #glycemia in diabetic mice
Women who #breastfeed exhibit #cognitive benefits after age 50
AbstractBackground and objectivesWomen who breastfeed may experience long-term benefits for their health in addition to the more widely-appreciated effects on the breastfed child. Breastfeeding may induce long-term effects on biopsychosocial systems implicated in brain health. Also, due to diminished breastfeeding in the post-industrial era, it is important to understand the lifespan implications of breastfeeding for… Continue reading Women who #breastfeed exhibit #cognitive benefits after age 50
Dietary #DHA prevents cognitive impairment and inflammatory gene expression in aged male rats fed a diet enriched with refined #carbohydrates
•A processed-foods diet (PD) impaired learning and memory in aged male rats. •PD increased inflammatory genes in the hippocampus and amygdala of aged rats. •DHA supplementation prevented memory deficits in PD-fed aged rats. •DHA supplementation ameliorated increases in inflammatory gene expression. •PD consumption led to increased weight gain in young and aged rats. AbstractThe consumption… Continue reading Dietary #DHA prevents cognitive impairment and inflammatory gene expression in aged male rats fed a diet enriched with refined #carbohydrates
Association of #Statins and 28-Day Mortality in Patients Hospitalized with #SARS CoV-2 Infection
Statins may be protective in SARS-CoV-2 infection. The aim of this study was to evaluate the effect of in-hospital statin use on 28-day mortality and ICU admission among patients with SARS-CoV-2 stratified into 4 groups: those who used statins prior to hospitalization (continued, discontinued) and those who did not (newly initiated, never). MethodsIn a cohort… Continue reading Association of #Statins and 28-Day Mortality in Patients Hospitalized with #SARS CoV-2 Infection
All-cause and cause-specific mortality in people with #mental disorders and intellectual disabilities, before and during the COVID-19 pandemic: cohort study
People with mental disorders and intellectual disabilities experience excess mortality compared with the general population. The impact of COVID-19 on exacerbating this, and in widening ethnic inequalities, is unclear. METHODSProspective data (N=167,122) from a large mental healthcare provider in London, UK, with deaths from 2019 to 2020, used to assess age- and gender-standardised mortality ratios… Continue reading All-cause and cause-specific mortality in people with #mental disorders and intellectual disabilities, before and during the COVID-19 pandemic: cohort study
Effect of Transcranial Near-Infrared #Light 1068 nm Upon #Memory Performance in Aging Healthy Individuals: A Pilot Study
We present a pilot study of near-infrared (NIR) 1068 nm transcranial photobiomodulation therapy (PBM-T). Impact upon motor function, memory, and processing speed in healthy individuals, older than 45 years of age, was evaluated. Methods: PBM-T was performed at home using a transcranial phototherapy device, a helmet that comprised 14 air cooled light emitting diode panel arrays,… Continue reading Effect of Transcranial Near-Infrared #Light 1068 nm Upon #Memory Performance in Aging Healthy Individuals: A Pilot Study
Incidence Rates and Predictors of Microvascular and Macrovascular Complications in Patients with Type 2 #Diabetes: Results from the Longitudinal Global DISCOVER Study
In a global prospective study of patients with relatively early-stage diabetes, microvascular and macrovascular complications were common and were associated with increased risk of subsequent hospitalization and death. •The strongest predictor of incident complications was the known atherosclerosis or heart failure at enrollment. •Poor glucose control and smoking were also associated with increased risk of… Continue reading Incidence Rates and Predictors of Microvascular and Macrovascular Complications in Patients with Type 2 #Diabetes: Results from the Longitudinal Global DISCOVER Study
2 Medical News 