Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection

Although SARS-CoV-2 infects the upper respiratory tract, we know little about the amount, type, and kinetics of antibodies (Ab) generated in the oral cavity in response to COVID-19 vaccination. We collected serum and saliva samples from participants receiving two doses of mRNA COVID-19 vaccines and measured the level of anti-SARS-CoV-2 Ab. We detected anti-Spike and …

Continue reading Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection

Mucosal immune response in BNT162b2 COVID-19 vaccine recipients

Although the BNT162b2 COVID-19 vaccine is known to induce IgG neutralizing antibodies in serum protecting against COVID-19, it has not been studied in detail whether it could generate specific immunity at mucosal sites, which represent the primary route of entry of SARS-CoV-2. MethodsSamples of serum and saliva of 60 BNT162b2-vaccinated healthcare workers were collected at …

Continue reading Mucosal immune response in BNT162b2 COVID-19 vaccine recipients

Functional human #IgA targets a conserved site on #malaria sporozoites

A role for IgA in malariaImmunoglobulin (Ig)A is known to play a protective role against pathogens at mucosal surfaces. However, the protective effects of IgA in the serum are less well understood, particularly in the context of pathogens such as Plasmodium falciparum. To address this question, Tan et al. isolated and characterized serum IgA from …

Continue reading Functional human #IgA targets a conserved site on #malaria sporozoites