Clostridioides difficile infection (CDI) is a major cause of morbidity among patients with inflammatory bowel disease (IBD). Diagnostic biomarkers for early detection of CDI are needed in clinical practice. The relationship between serum procalcitonin and CDI in IBD patients has not been investigated so far. Therefore, we aimed to evaluate the usefulness of measuring serum… Continue reading Serum #procalcitonin levels associate with #Clostridioides difficile infection in patients with #inflammatory bowel disease
Relationship Between #Ultraprocessed Food Intake and #Cardiovascular Health Among U.S. Adolescents: Results From the National Health and Nutrition Examination Survey 2007–2018
Studies of the association between ultraprocessed foods (UPF) and cardiovascular disease risk factors have been mainly focused on the adult population. This study examined the association between usual percentage of calories (%kcal) from UPF and the American Heart Association's seven cardiovascular health (CVH) metrics among U.S. adolescents aged 12–19 years. MethodsWe used data from the… Continue reading Relationship Between #Ultraprocessed Food Intake and #Cardiovascular Health Among U.S. Adolescents: Results From the National Health and Nutrition Examination Survey 2007–2018
Role of Adipocyte Na,K-ATPase Oxidant Amplification Loop in #Cognitive Decline and #Neurodegeneration
•Adipocytes induce phenotypical changes in neurodegeneration through adipocyte NKAL.•Adipocyte specific NaKtide inhibited NKAL and improved systemic homeostasis.•NaKtide improved adipocyte phenotype and improved markers of neurodegeneration.•NaKtide improved genomic profile of hippocampus and adipose tissue in WD fed mice. SummaryRecent studies suggest that a western diet may contribute to clinical neurodegeneration and dementia. Adipocyte-specific expression of the… Continue reading Role of Adipocyte Na,K-ATPase Oxidant Amplification Loop in #Cognitive Decline and #Neurodegeneration
Digging for data: How #sleep is losing out to roster design, sleep disorders, and lifestyle factors
Highlights•Shift start times <06:00, may result in sleep loss resulting in poor alertness. •Risk of sleep disorders increased with body mass and age. •Prevalence of shiftwork disorder and obstructive sleep apnea in mining is high. •Biomathematical modeling may be used to eliminate or reduce organizational risk. AbstractShift workers employed at a remote mining operation may… Continue reading Digging for data: How #sleep is losing out to roster design, sleep disorders, and lifestyle factors
Study: People Are Getting #Dumber
IQ scores have been steadily falling for decades, but genes aren't to blame – their environment is at fault. New research published this week in Proceedings of the National Academy of the Sciences of the United States of America examined the IQ scores of men born between 1962 and 1991. Researchers found that scores increased… Continue reading Study: People Are Getting #Dumber
Early insight into #antibody-dependent enhancement after SARS-CoV-2 mRNA #vaccination
Current vaccines, which induce a B-cell-mediated antibody response against the spike protein of SARS-CoV-2, have markedly reduced infection rates. However, the emergence of new variants as a result of SARS-CoV-2 evolution requires the development of novel vaccines that are T-cell-based and that target mutant-specific spike proteins along with ORF1ab or nucleocapsid protein. This approach is… Continue reading Early insight into #antibody-dependent enhancement after SARS-CoV-2 mRNA #vaccination
Impact of Sustained #Weight Loss on #Cardiometabolic Outcomes
Highlights•Sustained weight loss significantly lowers incidence of cardiometabolic outcomes.•Sustained weight loss significantly delays onset of cardiometabolic outcomes.•Greater weight loss significantly delays onset of cardiometabolic outcomes. Obesity increases the risk of developing type 2 diabetes, hypertension, and hyperlipidemia. We sought to determine the impact of obesity maintenance, weight regain, weight loss maintenance, and magnitudes of weight… Continue reading Impact of Sustained #Weight Loss on #Cardiometabolic Outcomes
Identification of a choroid plexus vascular barrier closing during #intestinal inflammation
Locking down access to the brainInflammatory bowel disease is best known for intestinal symptoms but can also cause a variety of extraintestinal manifestations in other organs. It can also be associated with cognitive and psychiatric effects, including anxiety and depression. Using mouse models of intestinal inflammation, Carloni et al. uncovered a potential pathogenic link between… Continue reading Identification of a choroid plexus vascular barrier closing during #intestinal inflammation
#Environmental risk factors and #cardiovascular diseases: a comprehensive expert review
AbstractNon-communicable diseases (NCDs) are fatal for more than 38 million people each year and are thus the main contributors to the global burden of disease accounting for 70% of mortality. The majority of these deaths are caused by cardiovascular disease (CVD). The risk of NCDs is strongly associated with exposure to environmental stressors such as… Continue reading #Environmental risk factors and #cardiovascular diseases: a comprehensive expert review
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