Personal protective equipment (PPE) can potentiate heat stress, which may have a negative impact on the wearer's performance, safety and well-being. In view of this, a survey was distributed to healthcare workers (HCWs) required to wear PPE during the coronavirus disease 2019 pandemic in the UK to evaluate perceived levels of heat stress and its… Continue reading #Heat stress and PPE during #COVID-19: impact on healthcare workers’ performance, safety and well-being in NHS settings
Visit-to-visit fasting blood #glucose variability and lifetime risk of #cardiovascular disease: a prospective study
Previous studies suggested an adverse association between higher fasting blood glucose (FBG) variability and cardiovascular disease (CVD). Lifetime risk provides an absolute risk assessment during the remainder of an individual’s life. However, the association between FBG variability and the lifetime risk of CVD is uncertain. ObjectiveWe aimed to investigate the effect of the visit-to-visit FBG… Continue reading Visit-to-visit fasting blood #glucose variability and lifetime risk of #cardiovascular disease: a prospective study
A microRNA signature that correlates with cognition and is a target against #cognitive decline
While some individuals age without pathological memory impairments, others develop age-associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. Thus, there is great need for the identification of inexpensive and minimal… Continue reading A microRNA signature that correlates with cognition and is a target against #cognitive decline
Age-related changes in #bone density, microarchitecture and strength in postmenopausal Black and White women: SWAN Longitudinal HR-pQCT Study
Higher fracture risk in White versus Black women is partly explained by lower BMD and worse bone microarchitecture in White women. However, whether rates of decline in bone density, microarchitecture and strength differ between postmenopausal Black and White women is unknown. Further, factors that influence rates of age-related bone microarchitecture deterioration remain ill-defined. Thus, over… Continue reading Age-related changes in #bone density, microarchitecture and strength in postmenopausal Black and White women: SWAN Longitudinal HR-pQCT Study
Association of accelerometer-derived #sleep measures with lifetime #psychiatric diagnoses: A cross-sectional study of 89,205 participants from the UK Biobank
Sleep problems are both symptoms of and modifiable risk factors for many psychiatric disorders. Wrist-worn accelerometers enable objective measurement of sleep at scale. Here, we aimed to examine the association of accelerometer-derived sleep measures with psychiatric diagnoses and polygenic risk scores in a large community-based cohort. Methods and findingsIn this post hoc cross-sectional analysis of… Continue reading Association of accelerometer-derived #sleep measures with lifetime #psychiatric diagnoses: A cross-sectional study of 89,205 participants from the UK Biobank
#Diet-induced #fasting ghrelin elevation reflects the recovery of #insulin sensitivity and visceral adiposity regression
Lower fasting-ghrelin-levels (FGL) are associated with obesity and metabolic syndrome. We aimed to explore the dynamics of FGL during weight-loss and its metabolic and adiposity-related manifestations beyond weight-loss. MethodsA secondary analysis of a clinical trial where we randomized participants with abdominal-obesity/dyslipidemia to one of three diets: healthy-dietary-guidelines (HDG), Mediterranean diet (MED), or green-MED diet, all… Continue reading #Diet-induced #fasting ghrelin elevation reflects the recovery of #insulin sensitivity and visceral adiposity regression
Cardiovascular health, genetic predisposition, and lifetime risk of type 2 #diabetes
Data on the lifetime risk of type 2 diabetes (T2D) incidence across different cardiovascular health (CVH) categories are scarce. Moreover, it remains unclear whether a genetic predisposition modifies this association. Methods and resultsUsing data from the prospective population-based Rotterdam Study, a CVH score (body mass index, blood pressure, total cholesterol, smoking status, diet, and physical… Continue reading Cardiovascular health, genetic predisposition, and lifetime risk of type 2 #diabetes
Changes in #metabolic syndrome status are associated with altered risk of #pancreatic cancer: A nationwide cohort study
Background & AimsMetabolic syndrome (MetS) is reversible; however, the effect of changes in MetS status on pancreatic cancer risk is unknown. We aimed to investigate the effects of changes and persistence in MetS status on pancreatic cancer risk. MethodsThis nationwide cohort study included 8,203,492 adults without cancer who underwent two consecutive biennial health screenings provided… Continue reading Changes in #metabolic syndrome status are associated with altered risk of #pancreatic cancer: A nationwide cohort study
Compensatory ion transport buffers daily protein #rhythms to regulate osmotic balance and cellular physiology
Between 6–20% of the cellular proteome is under circadian control and tunes mammalian cell function with daily environmental cycles. For cell viability, and to maintain volume within narrow limits, the daily variation in osmotic potential exerted by changes in the soluble proteome must be counterbalanced. The mechanisms and consequences of this osmotic compensation have not… Continue reading Compensatory ion transport buffers daily protein #rhythms to regulate osmotic balance and cellular physiology
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