Risk of failure in dual therapy versus triple therapy in naïve #HIV-patients: a systematic review and meta-analysis

Several attempts have been made to test different drug-sparing strategies to reduce the drug-burden and drug-related toxicities.. ..Fourteen studies were included, allowing a meta-analysis on 5,205 patients. The meta-analysis performed on studies that presented data at 48 weeks showed that the relative risk (RR) of treatment failure (TF) (RR>1 favoring triple therapy) in 10 studies was 1.20 (95%CI: 0.91-1.59, I 2: 49.2%); the RR of … Continue reading Risk of failure in dual therapy versus triple therapy in naïve #HIV-patients: a systematic review and meta-analysis

Effect of #Zinc Supplementation vs Placebo on Mortality Risk and #HIV Disease Progression Among HIV-Positive Adults With Heavy #Alcohol Use

.. A total of 254 participants (184 men [72%]; mean [SD] age, 34 [6] years) were enrolled in the trial; 126 were randomized to receive zinc, and 128 were randomized to receive placebo. Participants had high CD4 cell counts (mean [SD], 521 [292] cells/mm3), and 188 (74%) reported heavy drinking in the past week. In the main analyses, zinc supplementation did not affect changes in … Continue reading Effect of #Zinc Supplementation vs Placebo on Mortality Risk and #HIV Disease Progression Among HIV-Positive Adults With Heavy #Alcohol Use