Mortality among persons who inject #drugs: A prospective cohort followed over three decades in Baltimore, Maryland, USA

Over the past decades, people who inject drugs (PWID) have been impacted by the development of combination antiretroviral therapy (cART) to combat HIV/AIDS, the prescription opioid crisis, and increased use of lethal synthetic opioids. We measured how these dynamics have impacted mortality among PWID in an urban U.S. city. DesignProspective cohort study using data from …

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#COVID-19 Outcomes Among Persons Living With or Without Diagnosed #HIV Infection in New York State

New York State has been an epicenter for both the US coronavirus disease 2019 (COVID-19) and HIV/AIDS epidemics. Persons living with diagnosed HIV may be more prone to COVID-19 infection and severe outcomes, yet few studies have assessed this possibility at a population level.. ..A total of 2988 persons living with diagnosed HIV (2109 men …

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Risk of failure in dual therapy versus triple therapy in naΓ―ve #HIV-patients: a systematic review and meta-analysis

Several attempts have been made to test different drug-sparing strategies to reduce the drug-burden and drug-related toxicities.. ..Fourteen studies were included, allowing a meta-analysis on 5,205 patients. The meta-analysis performed on studies that presented data at 48 weeks showed that the relative risk (RR) of treatment failure (TF) (RR>1 favoring triple therapy) in 10 studies …

Continue reading Risk of failure in dual therapy versus triple therapy in naΓ―ve #HIV-patients: a systematic review and meta-analysis

Effect of #Zinc Supplementation vs Placebo on Mortality Risk and #HIV Disease Progression Among HIV-Positive Adults With Heavy #Alcohol Use

.. A total of 254 participants (184 men [72%]; mean [SD] age, 34 [6] years) were enrolled in the trial; 126 were randomized to receive zinc, and 128 were randomized to receive placebo. Participants had high CD4 cell counts (mean [SD], 521 [292] cells/mm3), and 188 (74%) reported heavy drinking in the past week. In …

Continue reading Effect of #Zinc Supplementation vs Placebo on Mortality Risk and #HIV Disease Progression Among HIV-Positive Adults With Heavy #Alcohol Use