Both type 1 and type 2 diabetes are associated with reduced β-cell mass or function, resulting from decreased proliferation and increased apoptosis. Understanding the signals governing β-cell survival and regeneration is critical for developing strategies to maintain healthy populations of these cells in individuals. Both forms of diabetes are associated with hyperglucagonemia and an increased… Continue reading #Glucagon blockade restores functional β-cell mass in type 1 #diabetic mice and enhances function of human islets
Category: Endocrinology
Association between #obesity with pattern and length of #menstrual cycle: The role of metabolic and hormonal markers
To evaluate in a sample of Chilean adult women, the association between adiposity markers with pattern and length of the menstrual cycle, assessing the influence of metabolic markers and hormones in this relationship. Study design We conducted a cross-sectional study involving 401 premenopausal women belonging to the DERCAM study (Determinants of Breast Cancer Risk) from… Continue reading Association between #obesity with pattern and length of #menstrual cycle: The role of metabolic and hormonal markers
Self- Monitoring via Digital Health in #Weight Loss Interventions: A Systematic Review Among Adults with Overweight or #Obesity
Objective: Self- monitoring is a core component of behavioral obesity treatment, but it is unknown how digital health has been used for self- monitoring, what engagement rates are achieved in these interven-tions, and how self- monitoring and weight loss are related. Methods: This systematic review examined digital self- monitoring in behavioral weight loss interventions among… Continue reading Self- Monitoring via Digital Health in #Weight Loss Interventions: A Systematic Review Among Adults with Overweight or #Obesity
Association of #Gastric Bypass Surgery With Risk of Developing #Diabetic #Retinopathy Among Patients With #Obesity and Type 2 Diabetes in Sweden
Knowledge of the incidence and progression of diabetic retinopathy (DR) after gastric bypass surgery (GBP) in patients with obesity and diabetes could guide the management of these patients. Objective To investigate the incidence of diabetic ocular complications in patients with type 2 diabetes after GBP compared with the incidence of diabetic ocular complications in a… Continue reading Association of #Gastric Bypass Surgery With Risk of Developing #Diabetic #Retinopathy Among Patients With #Obesity and Type 2 Diabetes in Sweden
Once-Weekly #Semaglutide in Adults with Overweight or #Obesity
Obesity is a global health challenge with few pharmacologic options. Whether adults with obesity can achieve weight loss with once-weekly semaglutide at a dose of 2.4 mg as an adjunct to lifestyle intervention has not been confirmed. METHODS In this double-blind trial, we enrolled 1961 adults with a body-mass index (the weight in kilograms divided… Continue reading Once-Weekly #Semaglutide in Adults with Overweight or #Obesity
Risk of Progression to #Diabetes Among Older Adults With Prediabetes
..Prediabetes defined by a glycated hemoglobin (HbA1c) level of 5.7% to 6.4%, impaired fasting glucose (IFG) level (FG level of 100-125 mg/dL), either, or both. Main Outcomes and Measures Incident total diabetes (physician diagnosis, glucose-lowering medication use, HbA1c level ≥6.5%, or FG level ≥126 mg/dL). Results A total of 3412 participants without diabetes (mean [SD]… Continue reading Risk of Progression to #Diabetes Among Older Adults With Prediabetes
Incidence of adverse #cardiovascular events in type 2 #diabetes mellitus patients after initiation of glucose‐lowering agents: A population‐based community study from the Shizuoka Kokuho database
Increased incidence of hospitalization for heart failure (HHF) among patients with diabetes is increasingly being reported. We investigated the incidence of adverse cardiovascular events including HHF among patients with type 2 diabetes mellitus, and the potential clinical improvement with sodium–glucose cotransporter 2 inhibitors (SGLT2i) using a contemporary administrative claims database from a large governmental district… Continue reading Incidence of adverse #cardiovascular events in type 2 #diabetes mellitus patients after initiation of glucose‐lowering agents: A population‐based community study from the Shizuoka Kokuho database
#Metformin Use Is Associated With Reduced Mortality in a Diverse Population With #COVID-19 and Diabetes
Coronavirus disease-2019 (COVID-19) is a growing pandemic with an increasing death toll that has been linked to various comorbidities as well as racial disparity. However, the specific characteristics of these at-risk populations are still not known and approaches to lower mortality are lacking.. ..The odds ratio of contracting COVID-19 was disproportionately high in Blacks/African-Americans (OR… Continue reading #Metformin Use Is Associated With Reduced Mortality in a Diverse Population With #COVID-19 and Diabetes
EUGLYCEMIC DIABETIC #KETOACIDOSIS WITH #COVID-19 INFECTION IN PATIENTS WITH TYPE 2 DIABETES TAKING #SGLT2 INHIBITORS
Diabetes mellitus is associated with poor outcomes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Diabetic ketoacidosis (DKA) has also been reported to occur with this virus. A cluster of cases of euglycemic DKA (euDKA) was identified in patients with type 2 diabetes mellitus using sodium-glucose cotransporter-2 inhibitors (SGLT2is) who developed SARS-CoV-2 infection.. ..Five… Continue reading EUGLYCEMIC DIABETIC #KETOACIDOSIS WITH #COVID-19 INFECTION IN PATIENTS WITH TYPE 2 DIABETES TAKING #SGLT2 INHIBITORS
