The action of mRNA-based vaccines requires the expression of the antigen in cells targeted by lipid nanoparticle–mRNA complexes. When the vaccine antigen is not fully retained by the producer cells, its local and systemic diffusion can have consequences depending on both the levels of antigen expression and its biological activity. A peculiarity of mRNA-based COVID-19… Continue reading The Immunologic Downsides Associated with the Powerful Translation of Current #COVID-19 Vaccine #mRNA Can Be Overcome by Mucosal Vaccines
Author: aledopress
Medicine and Technology enthusiast..
Membrane potential states gate #synaptic consolidation in human neocortical tissue
Synaptic mechanisms that contribute to human memory consolidation remain largely unexplored. Consolidation critically relies on sleep. During slow wave sleep, neurons exhibit characteristic membrane potential oscillations known as UP and DOWN states. Coupling of memory reactivation to these slow oscillations promotes consolidation, though the underlying mechanisms remain elusive. Here, we performed axonal and multineuron patch-clamp… Continue reading Membrane potential states gate #synaptic consolidation in human neocortical tissue
Advancements in wearable #heart sounds devices for the monitoring of #cardiovascular diseases
Cardiovascular diseases remain a leading global cause of mortality, underscoring the urgent need for intelligent diagnostic tools to enhance early detection, prediction, diagnosis, prevention, treatment, and recovery. This demand has spurred the advancement of wearable and flexible technologies, revolutionizing continuous, noninvasive, and remote heart sound (HS) monitoring—a vital avenue for assessing heart activity. The conventional… Continue reading Advancements in wearable #heart sounds devices for the monitoring of #cardiovascular diseases
Late #eating is associated with poor #glucose tolerance, independent of body weight, fat mass, energy intake and diet composition in prediabetes or early onset type 2 #diabetes
This study investigates the impact of habitual late calorie intake on glucose metabolism in adults with overweight or obesity and diet or metformin-controlled prediabetes or type 2 diabetes independently of body weight, fat mass, energy intake or diet composition. Participants (n = 26) were classified as Later Eaters (LE) if ≥45% daily calories were consumed after 5 pm… Continue reading Late #eating is associated with poor #glucose tolerance, independent of body weight, fat mass, energy intake and diet composition in prediabetes or early onset type 2 #diabetes
#Breakfast energy intake and dietary quality and trajectories of #cardiometabolic risk factors in older adults
Highlights•Eating 20−30% of daily energy in breakfast links to less adiposity in older adults.•It is also related to less triglycerides and more HDL cholesterol (HDL-C).•A high-quality breakfast is linked to better adiposity, HDL-C, and kidney function.•Healthy breakfast habits relate to healthy aging by improving heart risk factors. ObjectivesNot skipping breakfast is associated with a better… Continue reading #Breakfast energy intake and dietary quality and trajectories of #cardiometabolic risk factors in older adults
Short #Sleep Duration and #Hypertension: A Double Hit for the #Brain
Short sleep duration has been associated with an increased risk of cognitive impairment and dementia. Short sleep is associated with elevated blood pressure, yet the combined insult of short sleep and hypertension on brain health remains unclear. We assessed whether the association of sleep duration with cognition and vascular brain injury was moderated by hypertensive… Continue reading Short #Sleep Duration and #Hypertension: A Double Hit for the #Brain
#Teabag-derived micro/#nanoplastics (true-to-life MNPLs) as a surrogate for real-life exposure scenarios
Highlights•Nanoplastics were obtained from three teabag brands during a standard preparation.•ATR-FTIR shows nylon, polypropylene, and cellulose as constituents.•MNPLs release was higher for propylene and lower for nylon.•Uptake in Caco-2, HT29, and HT29-MTX human intestinal cells was determined.•Cell uptake depends on both cell type and chemical constitution of released MNPLs. AbstractThe potential health implications of environmental… Continue reading #Teabag-derived micro/#nanoplastics (true-to-life MNPLs) as a surrogate for real-life exposure scenarios
#Propranolol Reduces #Parkinson’s #Tremor and Inhibits Tremor-Related Activity in the Motor Cortex: A Placebo-Controlled Crossover Trial
AbstractObjectiveParkinson's disease (PD) resting tremor is thought to be initiated in the basal ganglia and amplified in the cerebello-thalamo-cortical circuit. Because stress worsens tremor, the noradrenergic system may play a role in amplifying tremor. We tested if and how propranolol, a non-selective beta-adrenergic receptor antagonist, reduces PD tremor and whether or not this effect is… Continue reading #Propranolol Reduces #Parkinson’s #Tremor and Inhibits Tremor-Related Activity in the Motor Cortex: A Placebo-Controlled Crossover Trial
Better #diet quality is associated with reduced body #pain in adults regardless of adiposity: Findings from the Whyalla Intergenerational Study of Health
Highlights•Better diet quality had a direct (beneficial) effect on pain.•Higher consumption of core foods was related to less pain in women, but not men.•Adiposity did not mediate the relationship between diet quality and pain.•Strategies for pain management should consider diet quality. AbstractDietary intake has been associated with pain and physical function, but it is unclear… Continue reading Better #diet quality is associated with reduced body #pain in adults regardless of adiposity: Findings from the Whyalla Intergenerational Study of Health
2 Medical News 