Background Acute coronary syndrome (ACS) is a global leading cause of morbidity, with residual inflammation contributing to recurrent events. Colchicine has been proposed as an adjunct therapy, but its efficacy remains uncertain.Methods We performed a systematic review and meta-analysis. PubMed, Embase and Cochrane databases were searched for randomised controlled trials (RCTs) data comparing colchicine versus… Continue reading #Colchicine in acute #coronary syndromes: a systematic review and meta-analysis of randomised controlled trials
Author: aledopress
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Rest #Activity Rhythms and their Association with #Cardiorespiratory Fitness and #Walking Energetics in #Older Adults: Study of Muscle, #Mobility and #Aging
Purpose It is recognized that disruptions in circadian behavior, such as with shift work or jet lag, are associated with diminished health. This known relationship implies that people with stronger indices of circadian behavior will exhibit improved physiology. To address the association between rhythmic activity behavior and physiology we proposed that metrics indicative of ‘more… Continue reading Rest #Activity Rhythms and their Association with #Cardiorespiratory Fitness and #Walking Energetics in #Older Adults: Study of Muscle, #Mobility and #Aging
Vitamin #D3 and marine ω-3 fatty acids supplementation and leukocyte #telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial
Limited studies suggest that vitamin D or omega 3 fatty acids (n–3 FAs) supplementation may be beneficial for telomere maintenance; however, evidence from large randomized clinical trials is lacking. We hypothesized that vitamin D or n–3 FAs supplementation reduce leukocyte telomere length (LTL) attrition over time by leveraging the VITamin D and OmegA-3 TriaL (VITAL)… Continue reading Vitamin #D3 and marine ω-3 fatty acids supplementation and leukocyte #telomere length: 4-year findings from the VITamin D and OmegA-3 TriaL (VITAL) randomized controlled trial
#Spironolactone vs #Amiloride for Resistant #HypertensionA Randomized Clinical Trial
Importance Amiloride has been proposed as an alternative to spironolactone for treating resistant hypertension. However, no randomized clinical trials have compared the efficacy of spironolactone and amiloride in patients with resistant hypertension.Objective To determine whether amiloride is noninferior to spironolactone in reducing home-measured systolic blood pressure (SBP) in patients with resistant hypertension.Design, Setting, and Participants … Continue reading #Spironolactone vs #Amiloride for Resistant #HypertensionA Randomized Clinical Trial
Increased #sedentary behavior is associated with #neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity
INTRODUCTIONSedentary behavior may be a modifiable risk factor for Alzheimer's disease (AD). We examined how sedentary behavior relates to longitudinal brain structure and cognitive changes in older adults.METHODSVanderbilt Memory and Aging Project participants (n = 404) completed actigraphy (7 days), neuropsychological assessment, and 3T brain MRI over a 7-year period. Cross-sectional and longitudinal linear regressions… Continue reading Increased #sedentary behavior is associated with #neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity
Dietary #Carbohydrate Intake, Carbohydrate Quality, and Healthy #Aging in Women
Importance Dietary carbohydrate quality is inversely associated with risks of chronic disease and all-cause mortality. However, limited evidence exists regarding the role of carbohydrate quality and dietary carbohydrate types in promoting healthy aging.Objective To evaluate the long-term role of dietary carbohydrate intake and carbohydrate quality in healthy aging.Design, Setting, and Participants This prospective cohort study… Continue reading Dietary #Carbohydrate Intake, Carbohydrate Quality, and Healthy #Aging in Women
Leadless #pacing in young patients
Leadless pacing has been established as an effective and safe therapy. The majority of published data relates to an older population. However, this therapy may be particularly attractive for a younger (<40 years) population where the complications of transvenous devices can be enhanced. These include having leads in the vasculature for a longer period of… Continue reading Leadless #pacing in young patients
Cumulative associations between #health behaviours, mental well-being, and health over 30 years
BackgroundBoth the number of risky health behaviours and the duration of exposure to these behaviours over time may increase the risk of later adverse outcomes. This study examined cumulative associations of risky health behaviours with both positive and negative aspects of mental well-being and health. It has a uniquely long follow-up period of over 30 years,… Continue reading Cumulative associations between #health behaviours, mental well-being, and health over 30 years
Modifiable factors for #irritable bowel syndrome: evidence from Mendelian randomisation approach
Background The potential modifiable factors influencing irritable bowel syndrome (IBS) have not been thoroughly documented. We aimed to systematically investigate the modifiable factors associated with IBS, while accounting for the impact of unobserved confounders and coexisting disorders.Methods Genetic correlation and Mendelian randomisation (MR) analyses were integrated to identify potential modifiable factors and coexisting disorders linked… Continue reading Modifiable factors for #irritable bowel syndrome: evidence from Mendelian randomisation approach
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