..After 1 913 978 person-years of follow-up, 12 156 (36.6%) women were obese and 2014 (6.1%) had received a diagnosis of type 2 diabetes. Women born by cesarean delivery were more likely to be classified as obese and to have received a diagnosis of type 2 diabetes during follow-up. The multivariable-adjusted relative risk of obesity among women born… Continue reading Association of Birth by Cesarean Delivery With #Obesity and Type 2 #Diabetes Among Adult Women
Tag: Diabetes
Cardiac #Autoimmunity Is Associated With Subclinical Myocardial Dysfunction in Patients With Type 1 #Diabetes Mellitus
The existence of a diabetic cardiomyopathy has been postulated to explain the increased risk of heart failure (HF) in patients with diabetes mellitus; however, whether mechanisms specific to type 1 diabetes mellitus (T1DM) affect the myocardium is unclear. We have recently shown that poor glycemic control in patients with T1DM followed in the DCCT (Diabetes… Continue reading Cardiac #Autoimmunity Is Associated With Subclinical Myocardial Dysfunction in Patients With Type 1 #Diabetes Mellitus
Hours lying down per day, as a proxy for sedentary behaviour and risk of #diabetes in young and middle-aged adults in Norway: an 11-year follow-up of the HUNT study
..362 individuals (2.1%) developed diabetes during an average of 11-year follow-up. Individuals who reported lying down ≥9 hours/day had an adjusted OR of 1.35 (95% CI 1.01 to 1.80) for incident diabetes compared with those lying down 8 hours/day. Lying down ≤7 hours/day was not associated with the risk of diabetes. In analysis stratified by physical activity, the… Continue reading Hours lying down per day, as a proxy for sedentary behaviour and risk of #diabetes in young and middle-aged adults in Norway: an 11-year follow-up of the HUNT study
Type 2 #diabetes influences bacterial tissue compartmentalisation in human obesity
..Visceral obesity is a key risk factor for type 2 diabetes (T2D). Whereas gut dysbiosis appears to be instrumental for this relationship, whether gut-associated signatures translocate to extra-intestinal tissues and how this affects host metabolism remain elusive ..We identified tissue-specific signatures with higher bacterial load in the liver and omental adipose tissue. Gut commensals, but… Continue reading Type 2 #diabetes influences bacterial tissue compartmentalisation in human obesity
Similar #Breast Cancer Risk in Women Older Than 65 Years Initiating Glargine, Detemir, and NPH Insulins
To assess whether initiation of insulin glargine (glargine), compared with initiation of neutral protamine Hagedorn (NPH) or insulin detemir (detemir), was associated with an increased risk of breast cancer in women with diabetes.. Ever use of glargine was not associated with an increased risk of breast cancer compared with NPH (HR 0.97; 95% CI 0.88–1.06)… Continue reading Similar #Breast Cancer Risk in Women Older Than 65 Years Initiating Glargine, Detemir, and NPH Insulins
Body #mass index, #diabetes, and the risk of #Parkinson’s disease
..A total of 33,443 individuals were diagnosed with PD during the follow‐up period (7.3 years). An increased risk of PD incidence was observed in the underweight group versus the normal group (adjusted hazard ratio: 1.28; 95% confidence interval: 1.21–1.36), whereas a decreased risk of PD incidence was observed (adjusted hazard ratio: 0.88; 95% confidence interval: 0.88–0.93)… Continue reading Body #mass index, #diabetes, and the risk of #Parkinson’s disease
#Ultraprocessed Food Consumption and Risk of Type 2 #Diabetes Among Participants of the NutriNet-Santé Prospective Cohort
Ultraprocessed foods (UPF) are widespread in Western diets. Their consumption has been associated in recent prospective studies with increased risks of all-cause mortality and chronic diseases such as cancer, cardiovascular diseases, hypertension, and dyslipidemia; however, data regarding diabetes are lacking. ..Consumption of UPF was associated with a higher risk of T2D (multi-adjusted hazard ratio [HR]… Continue reading #Ultraprocessed Food Consumption and Risk of Type 2 #Diabetes Among Participants of the NutriNet-Santé Prospective Cohort
Updating insights into #rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses
individual patient level data (IPD) ..The odds ratios for myocardial infarction, heart failure, cardiovascular related death, and non-cardiovascular related death were 1.17 (0.92 to 1.51), 1.54 (1.14 to 2.09), 1.15 (0.55 to 2.41), and 1.18 (0.60 to 2.30), respectively. For analyses including trials for which IPD were not available, odds ratios for myocardial infarction and… Continue reading Updating insights into #rosiglitazone and cardiovascular risk through shared data: individual patient and summary level meta-analyses
Hepatic Lipoprotein Export and Remission of Human Type 2 #Diabetes after #Weight Loss
..Liver fat, VLDL1-triglyceride production, and intra-pancreatic fat decreased after weight loss and remained normalized after 24 months of remission. First-phase insulin response remained increased only in those maintaining diabetes remission. Compared with those in remission at 24 months, individuals who relapsed after initial remission had a greater rise in the content of VLDL1-triglyceride and VLDL1-palmitic… Continue reading Hepatic Lipoprotein Export and Remission of Human Type 2 #Diabetes after #Weight Loss
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