To assess the role of serum ferritin and transferrin with prevalent and incident type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) and whether these associations are independent of inflammatory markers and hepatic enzymes.. Serum ferritin concentrations were associated with a higher prevalence of T2DM (total population OR: 1.16 [95% CI: 1.07, 1.26]; men OR:… Continue reading Associations of iron markers with type 2 #diabetes mellitus and metabolic syndrome: Results from the prospective SHIP study
Tag: Diabetes
#Metformin users with diabetes and individuals without #diabetes were at lower risk of overall cancer incidence than metformin non-users with diabetes based on the Korean NHIS-HEALS cohort
Several studies have reported the preventive effect of metformin on cancer development. This study aimed to investigate the relationship between use of metformin and risk of cancer in Koreans.. ..A total of 323,430 subjects was enrolled (301,905 individuals without diabetes [No DM], 8,643 diabetic patients with metformin treatment [metformin users], and 12,882 diabetic patients without… Continue reading #Metformin users with diabetes and individuals without #diabetes were at lower risk of overall cancer incidence than metformin non-users with diabetes based on the Korean NHIS-HEALS cohort
FDA approves new treatment for a type of heart failure
Today, the U.S. Food and Drug Administration approved Farxiga (dapagliflozin) oral tablets for adults with heart failure with reduced ejection fraction to reduce the risk of cardiovascular death and hospitalization for heart failure. Heart failure occurs when the heart does not pump enough blood to support the body’s needs, and this type of heart failure… Continue reading FDA approves new treatment for a type of heart failure
#Obesity, unfavourable lifestyle and genetic risk of type 2 #diabetes: a case-cohort study
Obesity (BMI ≥ 30 kg/m2) and unfavourable lifestyle were associated with higher risk for incident type 2 diabetes regardless of genetic predisposition (p > 0.05 for GRS–obesity and GRS–lifestyle interaction). The effect of obesity on type 2 diabetes risk (HR 5.81 [95% CI 5.16, 6.55]) was high, whereas the effects of high genetic risk (HR 2.00 [95% CI 1.76,… Continue reading #Obesity, unfavourable lifestyle and genetic risk of type 2 #diabetes: a case-cohort study
Association of Birth by Cesarean Delivery With #Obesity and Type 2 #Diabetes Among Adult Women
..After 1 913 978 person-years of follow-up, 12 156 (36.6%) women were obese and 2014 (6.1%) had received a diagnosis of type 2 diabetes. Women born by cesarean delivery were more likely to be classified as obese and to have received a diagnosis of type 2 diabetes during follow-up. The multivariable-adjusted relative risk of obesity among women born… Continue reading Association of Birth by Cesarean Delivery With #Obesity and Type 2 #Diabetes Among Adult Women
Cardiac #Autoimmunity Is Associated With Subclinical Myocardial Dysfunction in Patients With Type 1 #Diabetes Mellitus
The existence of a diabetic cardiomyopathy has been postulated to explain the increased risk of heart failure (HF) in patients with diabetes mellitus; however, whether mechanisms specific to type 1 diabetes mellitus (T1DM) affect the myocardium is unclear. We have recently shown that poor glycemic control in patients with T1DM followed in the DCCT (Diabetes… Continue reading Cardiac #Autoimmunity Is Associated With Subclinical Myocardial Dysfunction in Patients With Type 1 #Diabetes Mellitus
Hours lying down per day, as a proxy for sedentary behaviour and risk of #diabetes in young and middle-aged adults in Norway: an 11-year follow-up of the HUNT study
..362 individuals (2.1%) developed diabetes during an average of 11-year follow-up. Individuals who reported lying down ≥9 hours/day had an adjusted OR of 1.35 (95% CI 1.01 to 1.80) for incident diabetes compared with those lying down 8 hours/day. Lying down ≤7 hours/day was not associated with the risk of diabetes. In analysis stratified by physical activity, the… Continue reading Hours lying down per day, as a proxy for sedentary behaviour and risk of #diabetes in young and middle-aged adults in Norway: an 11-year follow-up of the HUNT study
Type 2 #diabetes influences bacterial tissue compartmentalisation in human obesity
..Visceral obesity is a key risk factor for type 2 diabetes (T2D). Whereas gut dysbiosis appears to be instrumental for this relationship, whether gut-associated signatures translocate to extra-intestinal tissues and how this affects host metabolism remain elusive ..We identified tissue-specific signatures with higher bacterial load in the liver and omental adipose tissue. Gut commensals, but… Continue reading Type 2 #diabetes influences bacterial tissue compartmentalisation in human obesity
Similar #Breast Cancer Risk in Women Older Than 65 Years Initiating Glargine, Detemir, and NPH Insulins
To assess whether initiation of insulin glargine (glargine), compared with initiation of neutral protamine Hagedorn (NPH) or insulin detemir (detemir), was associated with an increased risk of breast cancer in women with diabetes.. Ever use of glargine was not associated with an increased risk of breast cancer compared with NPH (HR 0.97; 95% CI 0.88–1.06)… Continue reading Similar #Breast Cancer Risk in Women Older Than 65 Years Initiating Glargine, Detemir, and NPH Insulins
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