BackgroundDisturbances in brain cholesterol homeostasis may be involved in the pathogenesis of Alzheimer’s disease (AD). Lipid-lowering medications could interfere with neurodegenerative processes in AD through cholesterol metabolism or other mechanisms.ObjectiveTo explore the association between the use of lipid-lowering medications and cognitive decline over time in a cohort of patients with AD or mixed dementia with… Continue reading #Statins and cognitive decline in patients with #Alzheimer’s and mixed dementia: a longitudinal registry-based cohort study
Short Oral Antibiotic Therapy for Pediatric Febrile #Urinary Tract Infections: A Randomized Trial
Febrile urinary tract infection (fUTI) in well-appearing children is conventionally treated with a standard 10-day course of oral antibiotic. The objective of this study is to determine the noninferiority (5% threshold) of a 5-day amoxicillin-clavulanate course compared with a 10-day regimen to treat fUTIs.METHODSThis is a multicenter, investigator-initiated, parallel-group, randomized, controlled trial. We randomly assigned… Continue reading Short Oral Antibiotic Therapy for Pediatric Febrile #Urinary Tract Infections: A Randomized Trial
Effects of calibrated blue–yellow changes in light on the human #circadian clock
Evening exposure to short-wavelength light can affect the circadian clock, sleep and alertness. Intrinsically photosensitive retinal ganglion cells expressing melanopsin are thought to be the primary drivers of these effects. Whether colour-sensitive cones also contribute is unclear. Here, using calibrated silent-substitution changes in light colour along the blue–yellow axis, we investigated whether mechanisms of colour… Continue reading Effects of calibrated blue–yellow changes in light on the human #circadian clock
Changes in #Hospital Adverse Events and Patient Outcomes Associated With #Private Equity Acquisition
The effects of private equity acquisitions of US hospitals on the clinical quality of inpatient care and patient outcomes remain largely unknown.Objective To examine changes in hospital-acquired adverse events and hospitalization outcomes associated with private equity acquisitions of US hospitals.Design, Setting, and Participants Data from 100% Medicare Part A claims for 662 095 hospitalizations at 51 private equity–acquired… Continue reading Changes in #Hospital Adverse Events and Patient Outcomes Associated With #Private Equity Acquisition
Multi-site #microbiota alteration is a hallmark of kidney #stone formation
Inquiry of microbiota involvement in kidney stone disease (KSD) has largely focussed on potential oxalate handling abilities by gut bacteria and the increased association with antibiotic exposure. By systematically comparing the gut, urinary, and oral microbiota of 83 stone formers (SF) and 30 healthy controls (HC), we provide a unified assessment of the bacterial contribution… Continue reading Multi-site #microbiota alteration is a hallmark of kidney #stone formation
Abstract 13719: Minimal and Delayed Age-Related Increase of Arterial #Stiffness Among Tsimane Forager-Horticulturalists
Background: Tsimane forager-farmers of the Bolivian Amazon exhibit a distinct trajectory of vascular aging, characterized by low age-related increases in BP, the lowest levels of coronary calcification ever reported, and robust VO2 max. However, the prevalence of arterial stiffness (ArSt) in this population and its association with age and other cardiovascular risk factors are unknown.Methods: Large artery elasticity… Continue reading Abstract 13719: Minimal and Delayed Age-Related Increase of Arterial #Stiffness Among Tsimane Forager-Horticulturalists
Clinically apparent #Helicobacter pylori infection and the risk of incident #Alzheimer’s disease: A population-based nested case-control study
INTRODUCTIONOur population-based study assessed whether clinically apparent Helicobacter pylori infection (CAHPI) is associated with the risk of Alzheimer's disease (AD).METHODSWe assembled a population-based cohort of all dementia-free subjects in the United Kingdom's Clinical Practice Research Datalink (UK CPRD), aged ≥50 years (1988–2017). Using a nested case-control approach, we matched each newly developed case of AD with 40… Continue reading Clinically apparent #Helicobacter pylori infection and the risk of incident #Alzheimer’s disease: A population-based nested case-control study
Enhanced SREBP2-driven #cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis
The metabolic and signaling pathways regulating aggressive mesenchymal colorectal cancer (CRC) initiation and progression through the serrated route are largely unknown. Although relatively well characterized as BRAF mutant cancers, their poor response to current targeted therapy, difficult preneoplastic detection, and challenging endoscopic resection make the identification of their metabolic requirements a priority. Here, we demonstrate… Continue reading Enhanced SREBP2-driven #cholesterol biosynthesis by PKCλ/ι deficiency in intestinal epithelial cells promotes aggressive serrated tumorigenesis
#Walking speed and the risk of type 2 #diabetes: a systematic review and meta-analysis
Objective To investigate the association between walking speed and the risk of type 2 diabetes.Design Systematic review and meta-analysis.Data sources PubMed, Scopus, CENTRAL and Web of Science to 30 May 2023.Eligibility criteria for selecting studies We included cohort studies that explored the association between walking speed and the risk of type 2 diabetes in adults. We used random-effects meta-analyses… Continue reading #Walking speed and the risk of type 2 #diabetes: a systematic review and meta-analysis
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