Social interactions profoundly influence animal development, physiology, and behavior. Yet, how sleep—a central behavioral and neurophysiological process—is modulated by social interactions is poorly understood. Here, we characterized sleep behavior and neurophysiology in freely moving and co-living mice under different social conditions. We utilized wireless neurophysiological devices to simultaneously record multiple individuals within a group for 24 h, alongside video acquisition. We… Continue reading Neurophysiological and behavioral synchronization in group-living and #sleeping mice
Cortical reactivations predict future sensory responses
Many theories of offline memory consolidation posit that the pattern of neurons activated during a salient sensory experience will be faithfully reactivated, thereby stabilizing the pattern1,2. However, sensory-evoked patterns are not stable but, instead, drift across repeated experiences3,4,5,6. Here, to investigate the relationship between reactivations and the drift of sensory representations, we imaged the calcium… Continue reading Cortical reactivations predict future sensory responses
Dietary #circadian rhythms and #cardiovascular disease risk in the prospective NutriNet-Santé cohort
Dietary circadian rhythms and #cardiovascular disease risk in the prospective NutriNet-Santé cohortDaily eating/fasting cycles synchronise circadian peripheral clocks, involved in the regulation of the cardiovascular system. However, the associations of daily meal and fasting timing with cardiovascular disease (CVD) incidence remain unclear. We used data from 103,389 adults in the NutriNet-Santé study. Meal timing and… Continue reading Dietary #circadian rhythms and #cardiovascular disease risk in the prospective NutriNet-Santé cohort
Woodcuts as Reading Guides: How Images Shaped Knowledge Transmission in Medical-Astrological Books in Dutch (1500-1550) by Andrea van Leerdam (2023)
Woodcuts as Reading Guides: How Images Shaped Knowledge Transmission in Medical-Astrological Books in Dutch (1500-1550) by Andrea van Leerdam (2023) In the first half of the sixteenth century, the Low Countries saw the rise of a lively market for practical and instructive books that targeted non-specialist readers. This study shows how woodcuts in vernacular books… Continue reading Woodcuts as Reading Guides: How Images Shaped Knowledge Transmission in Medical-Astrological Books in Dutch (1500-1550) by Andrea van Leerdam (2023)
#Statin Use and the Risk of Venous #Thromboembolism in Women Taking #Hormone Therapy
Although hormone therapy (HT) in perimenopausal women is associated with increased risk for venous thromboembolism (VTE), it is unclear to what extent statins may mitigate this HT-associated risk.Objective To estimate VTE risk in women aged 50 to 64 years taking HT with or without statins.Design, Setting, and Participants This nested case-control study analyzed data from a commercially… Continue reading #Statin Use and the Risk of Venous #Thromboembolism in Women Taking #Hormone Therapy
NR-SAFE: a randomized, double-blind safety trial of high dose #nicotinamide riboside in #Parkinson’s disease
Nicotinamide adenine dinucleotide (NAD) replenishment therapy using nicotinamide riboside (NR) shows promise for Parkinson’s disease (PD) and other neurodegenerative disorders. However, the optimal dose of NR remains unknown, and doses exceeding 2000 mg daily have not been tested in humans. To evaluate the safety of high-dose NR therapy, we conducted a single-center, randomized, placebo-controlled, double-blind,… Continue reading NR-SAFE: a randomized, double-blind safety trial of high dose #nicotinamide riboside in #Parkinson’s disease
Deciphering #Tachypnea: A Physician’s Perspective on Pathophysiology and Implications
Tachypnea, a rapid and shallow breathing pattern, is a clinical sign that beckons the attention of physicians, serving as a vital indicator of an underlying physiological disturbance. As physicians, our keen understanding of the pathophysiology behind tachypnea is pivotal in unraveling its implications and guiding us toward the appropriate diagnostic and therapeutic interventions. Join me… Continue reading Deciphering #Tachypnea: A Physician’s Perspective on Pathophysiology and Implications
Detecting Severe #AKI in Hospitalized Patients with Biomarkers of Kidney Injury – A Physician’s Guide to Precision Diagnosis
Acute Kidney Injury (AKI) is a critical concern in hospitalized patients, associated with increased morbidity, mortality, and healthcare costs. The ability to detect AKI early and accurately is paramount for timely intervention and improved patient outcomes. In this post, I embark on a physician’s journey to explore the world of biomarkers for kidney injury, shedding… Continue reading Detecting Severe #AKI in Hospitalized Patients with Biomarkers of Kidney Injury – A Physician’s Guide to Precision Diagnosis
Simultaneous Comparisons of 25 Acute #Migraine Medications Based on 10 Million Users’ Self-Reported Records From a Smartphone Application
Many acute treatment options exist for migraine. However, large-scale, head-to-head comparisons of treatment effectiveness from real-world patient experience reports are lacking.MethodsThis is a retrospective analysis of 10,842,795 migraine attack records extracted from an e-diary smartphone application between June 30, 2014, and July 2, 2020. We analyzed 25 acute medications among seven classes- acetaminophen, NSAIDs, triptans,… Continue reading Simultaneous Comparisons of 25 Acute #Migraine Medications Based on 10 Million Users’ Self-Reported Records From a Smartphone Application
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