..1α,25-dihydroxyvitamin D3 signals via the Vitamin D Receptor (VDR). Higher serum vitamin D is associated with thinner primary melanoma and better outcome, although a causal mechanism has not been established. As melanoma patients commonly avoid sun exposure, and consequent vitamin D deficiency might worsen outcomes, we interrogated 703 primary melanoma transcriptomes to understand the role… Continue reading Vitamin #D-VDR signaling inhibits Wnt/beta-catenin-mediated #melanoma progression and promotes anti-tumor immunity
#Antihypertensive medications and risk for incident #dementia and #Alzheimer’s disease: a meta-analysis of individual participant data from prospective cohort studies
..We assessed the association of incident dementia and clinical Alzheimer's disease with use of five AHM classes, within strata of baseline high (systolic blood pressure [SBP] ≥140 mm Hg or diastolic blood pressure [DBP] ≥90 mm Hg) and normal (SBP <140 mm Hg and DBP <90 mm Hg) blood pressure. ..There were 3728 incident cases… Continue reading #Antihypertensive medications and risk for incident #dementia and #Alzheimer’s disease: a meta-analysis of individual participant data from prospective cohort studies
Activity of Hospital #Disinfectants against Vegetative Cells and Spores of #Clostridioides difficile Embedded in Biofilms
Clostridioides difficile spores can survive in the environment either in mono- or mixed-species biofilms. However, no previous studies have investigated chemical disinfection of C. difficile spores embedded in biofilms.. C. difficile vegetative cells and spores were recovered from biofilms regardless the type of biofilm growth or biofilm growth time. No disinfectant was able to completely… Continue reading Activity of Hospital #Disinfectants against Vegetative Cells and Spores of #Clostridioides difficile Embedded in Biofilms
American Academy of #Pediatrics – Section on #Surgery Five Things Physicians and Patients Should Question
. Avoid the routine use of whole-body computed #tomography (CT) scanning (pan-scanning) in pediatric trauma patients. . Avoid using computed tomography (CT scan) as the first-line imaging modality in the evaluation of suspected appendicitis in children. Ultrasound should be done first with a CT scan or magnetic resonance imaging (MRI) considered in equivocal cases. .… Continue reading American Academy of #Pediatrics – Section on #Surgery Five Things Physicians and Patients Should Question
#Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults. A 10-year cohort
..Three insomnia symptoms were assessed with self-reported difficulties in initiating or maintaining sleep, early morning awakening, and daytime dysfunction for at least 3 d/wk at baseline ..Cox regressions showed that 3 insomnia symptoms were associated with increased risk of total #CVD, with respective adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of 1.09 (95%… Continue reading #Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults. A 10-year cohort
Evidence-based clinical practice guideline on #antibiotic use for the urgent management of pulpal- and periapical-related #dental pain and intraoral swelling
..systematic review and formulated clinical recommendations for the urgent management of symptomatic irreversible pulpitis with or without symptomatic apical #periodontitis, pulp necrosis and symptomatic apical periodontitis, or pulp necrosis and localized acute apical abscess using antibiotics, either alone or as adjuncts to definitive, conservative dental treatment (DCDT) in immunocompetent adults. The panel formulated 5 clinical… Continue reading Evidence-based clinical practice guideline on #antibiotic use for the urgent management of pulpal- and periapical-related #dental pain and intraoral swelling
Association Between #Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical #Hypothyroidism
..The hypothyroid symptoms score decreased from 21.7 at baseline to 19.3 at 12 months in the levothyroxine group vs from 19.8 at baseline to 17.4 at 12 months in the placebo group (adjusted between-group difference, 1.3 [95% CI, −2.7 to 5.2]; P = .53). The tiredness score increased from 25.5 at baseline to 28.2 at 12 months… Continue reading Association Between #Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical #Hypothyroidism
Is #running associated with a lower risk of all-cause, #cardiovascular and cancer #mortality, and is the more the better? A systematic review and meta-analysis
Fourteen studies from six prospective cohorts with a pooled sample of 232 149 participants were included. In total, 25 951 deaths were recorded during 5.5–35 year follow-ups. Our meta-analysis showed that running participation is associated with 27%, 30% and 23% lower risk of all-cause (pooled adjusted hazard ratio (HR)=0.73; 95% confidence interval (CI) 0.68 to 0.79), cardiovascular (HR=0.70;… Continue reading Is #running associated with a lower risk of all-cause, #cardiovascular and cancer #mortality, and is the more the better? A systematic review and meta-analysis
Does chronic high-intensity #endurance training have an effect on cardiovascular markers of active populations and athletes? Systematic review and meta-analysis
There was significant improvement in high-density #lipoprotein with weighted standardised mean difference and effect size=−1.06 (−1.83 to −0.30), p=0.006. We have also observed a significant reduction in low-density lipoprotein and total cholesterol with weighted standardised mean difference and effect size=−0.97 (−1.58 to −0.36), p=0.002, and = −0.78 (−1.34 to −0.22), p=0.007, respectively. There was a… Continue reading Does chronic high-intensity #endurance training have an effect on cardiovascular markers of active populations and athletes? Systematic review and meta-analysis
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