Myocardial injury with ST-segment elevation has been observed in patients with coronavirus disease 2019 (Covid-19). Here, we describe our experience in the initial month of the Covid-19 outbreak in New York City. Patients with confirmed Covid-19 who had ST-segment elevation on electrocardiography were included in the study from six New York hospitals. Patients with Covid-19… Continue reading #ST-Segment Elevation in Patients with #Covid-19 — A Case Series
A salt-induced kinase is required for the metabolic regulation of #sleep
Many lines of evidence point to links between sleep regulation and energy homeostasis, but mechanisms underlying these connections are unknown. During Caenorhabditis elegans sleep, energetic stores are allocated to nonneural tasks with a resultant drop in the overall fat stores and energy charge. Mutants lacking KIN-29, the C. elegans homolog of a mammalian Salt-Inducible Kinase… Continue reading A salt-induced kinase is required for the metabolic regulation of #sleep
Adherence to Life-Style Recommendations and #Attention-Deficit/Hyperactivity Disorder A Population-Based Study of Children Aged 10 to 11 Years
The incidence of attention-deficit/hyperactivity disorder (ADHD) among children and youth is high, and temporal increases have been paralleled by deteriorating life-styles. Poor diet quality, physical inactivity, poor sleep habits, and sedentary behaviors have all been associated with ADHD.. ..Before age 14 years, 10.8% of students received an ADHD diagnosis. Meeting recommendations for vegetables and fruit,… Continue reading Adherence to Life-Style Recommendations and #Attention-Deficit/Hyperactivity Disorder A Population-Based Study of Children Aged 10 to 11 Years
Research Five-year risk of admission to long-term care home and death for older adults given a new diagnosis of #dementia: a population-based retrospective cohort study
After diagnosis of a health condition, information about survival and potential transition from community into institutional care can be helpful for patients and care providers. We sought to describe the association between a new diagnosis of dementia and risk of admission to a long-term care home and death at 5 years.. ..age ≥ 90 yr;… Continue reading Research Five-year risk of admission to long-term care home and death for older adults given a new diagnosis of #dementia: a population-based retrospective cohort study
Primate auditory prototype in the evolution of the arcuate fasciculus
The human arcuate fasciculus pathway is crucial for #language, interconnecting posterior temporal and inferior frontal areas. Whether a monkey homolog exists is controversial and the nature of human-specific specialization unclear. Using monkey, ape and human auditory functional fields and diffusion-weighted MRI, we identified homologous pathways originating from the auditory cortex. This discovery establishes a primate… Continue reading Primate auditory prototype in the evolution of the arcuate fasciculus
α-Synuclein-specific T cell reactivity is associated with preclinical and early #Parkinson’s disease
..diagnosis of motor Parkinson’s disease (PD) is preceded by a prolonged premotor phase with accumulating neuronal damage. Here we examined the temporal relation between α-synuclein (α-syn) T cell reactivity and PD. A longitudinal case study revealed that elevated α-syn-specific T cell responses were detected prior to the diagnosis of motor PD, and declined after. The… Continue reading α-Synuclein-specific T cell reactivity is associated with preclinical and early #Parkinson’s disease
Maternal #Hypertensive Pregnancy Disorders and #Mental Disorders in Children
The associations of maternal hypertensive pregnancy disorders with offspring mental disorders remain unclear. We examined whether maternal hypertensive disorders and maximum blood pressure during pregnancy predict offspring childhood mental disorders, whether the associations are independent of maternal and paternal mental disorders and paternal hypertensive disorders, independent of or additive with maternal early pregnancy overweight/obesity and… Continue reading Maternal #Hypertensive Pregnancy Disorders and #Mental Disorders in Children
Association of #Cigarette Smoking With Antineutrophil Cytoplasmic Antibody–Associated #Vasculitis
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a systemic small vessel vasculitis characterized by circulating ANCAs targeting proteinase 3 (PR3) or myeloperoxidase (MPO) and associated with excess morbidity and mortality. Myeloperoxidase-ANCA–positive AAV and PR3-ANCA–positive AAV are increasingly recognized to have differences in genetic risk, pathogenesis, and response to treatment. Risk factors for AAV, including cigarette… Continue reading Association of #Cigarette Smoking With Antineutrophil Cytoplasmic Antibody–Associated #Vasculitis
Effect of Smartphone-Enabled #Health Monitoring Devices vs Regular Follow-up on Blood Pressure Control Among Patients After Myocardial #Infarction
..For patients randomized to regular care, 4 physical outpatient clinic visits were scheduled in the year following the initial event. In the intervention group, patients were given 4 smartphone-compatible devices (weight scale, BP monitor, rhythm monitor, and step counter). In addition, 2 in-person outpatient clinic visits were replaced by electronic visits ..In total, 200 patients… Continue reading Effect of Smartphone-Enabled #Health Monitoring Devices vs Regular Follow-up on Blood Pressure Control Among Patients After Myocardial #Infarction
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