Importance Amiloride has been proposed as an alternative to spironolactone for treating resistant hypertension. However, no randomized clinical trials have compared the efficacy of spironolactone and amiloride in patients with resistant hypertension.Objective To determine whether amiloride is noninferior to spironolactone in reducing home-measured systolic blood pressure (SBP) in patients with resistant hypertension.Design, Setting, and Participants … Continue reading #Spironolactone vs #Amiloride for Resistant #HypertensionA Randomized Clinical Trial
Increased #sedentary behavior is associated with #neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity
INTRODUCTIONSedentary behavior may be a modifiable risk factor for Alzheimer's disease (AD). We examined how sedentary behavior relates to longitudinal brain structure and cognitive changes in older adults.METHODSVanderbilt Memory and Aging Project participants (n = 404) completed actigraphy (7 days), neuropsychological assessment, and 3T brain MRI over a 7-year period. Cross-sectional and longitudinal linear regressions… Continue reading Increased #sedentary behavior is associated with #neurodegeneration and worse cognition in older adults over a 7-year period despite high levels of physical activity
Dietary #Carbohydrate Intake, Carbohydrate Quality, and Healthy #Aging in Women
Importance Dietary carbohydrate quality is inversely associated with risks of chronic disease and all-cause mortality. However, limited evidence exists regarding the role of carbohydrate quality and dietary carbohydrate types in promoting healthy aging.Objective To evaluate the long-term role of dietary carbohydrate intake and carbohydrate quality in healthy aging.Design, Setting, and Participants This prospective cohort study… Continue reading Dietary #Carbohydrate Intake, Carbohydrate Quality, and Healthy #Aging in Women
Leadless #pacing in young patients
Leadless pacing has been established as an effective and safe therapy. The majority of published data relates to an older population. However, this therapy may be particularly attractive for a younger (<40 years) population where the complications of transvenous devices can be enhanced. These include having leads in the vasculature for a longer period of… Continue reading Leadless #pacing in young patients
Cumulative associations between #health behaviours, mental well-being, and health over 30 years
BackgroundBoth the number of risky health behaviours and the duration of exposure to these behaviours over time may increase the risk of later adverse outcomes. This study examined cumulative associations of risky health behaviours with both positive and negative aspects of mental well-being and health. It has a uniquely long follow-up period of over 30 years,… Continue reading Cumulative associations between #health behaviours, mental well-being, and health over 30 years
Modifiable factors for #irritable bowel syndrome: evidence from Mendelian randomisation approach
Background The potential modifiable factors influencing irritable bowel syndrome (IBS) have not been thoroughly documented. We aimed to systematically investigate the modifiable factors associated with IBS, while accounting for the impact of unobserved confounders and coexisting disorders.Methods Genetic correlation and Mendelian randomisation (MR) analyses were integrated to identify potential modifiable factors and coexisting disorders linked… Continue reading Modifiable factors for #irritable bowel syndrome: evidence from Mendelian randomisation approach
Phase 3 Trial of #Semaglutide in #Metabolic Dysfunction–Associated Steatohepatitis
Semaglutide, a glucagon-like peptide-1 receptor agonist, is a candidate for the treatment of metabolic dysfunction–associated steatohepatitis (MASH).MethodsIn this ongoing phase 3, multicenter, randomized, double-blind, placebo-controlled trial, we assigned 1197 patients with biopsy-defined MASH and fibrosis stage 2 or 3 in a 2:1 ratio to receive once-weekly subcutaneous semaglutide at a dose of 2.4 mg or… Continue reading Phase 3 Trial of #Semaglutide in #Metabolic Dysfunction–Associated Steatohepatitis
Dysfunctional one-carbon metabolism identifies #vitamins B6, B9, B12, and choline as neuroprotective in #glaucoma
Highlights• Elevated retinal homocysteine is a pathogenic feature of glaucoma• One-carbon metabolism is dysregulated in glaucoma• Oral B6, B9, B12, and choline is neuroprotective in animal modelsSummaryGlaucoma, characterized by the loss of retinal ganglion cells (RGCs), is a leading cause of blindness for which there are no neuroprotective therapies. To explore observations of elevated homocysteine… Continue reading Dysfunctional one-carbon metabolism identifies #vitamins B6, B9, B12, and choline as neuroprotective in #glaucoma
3-month program of time-restricted #eating at any time of the day supports long-term #weight loss in adults with overweight or obesity
Three months of time-restricted eating (TRE), irrespective of whether it is earlier or later in the day, may be a promising strategy for sustaining long-term weight loss in adults with overweight or obesity, according to preliminary results of a randomised controlled trial being presented at this year’s European Congress on Obesity (ECO) in Malaga, Spain… Continue reading 3-month program of time-restricted #eating at any time of the day supports long-term #weight loss in adults with overweight or obesity
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