Severe COVID-19 can manifest in rapid decompensation and respiratory failure with elevated inflammatory markers, consistent with cytokine release syndrome for which IL-6 blockade is approved treatment We assessed effectiveness and safety of IL-6 blockade with tocilizumab in a single-center cohort of patients with COVID-19 requiring mechanical ventilation. The primary endpoint was survival probability post-intubation; secondary… Continue reading #Tocilizumab for treatment of mechanically ventilated patients with #COVID-19
Age- and Weight-Adapted Dose of #Prasugrel Versus Standard Dose of #Ticagrelor in Patients With Acute #Coronary Syndromes
The efficacy and safety of a reduced dose of prasugrel versus a standard dose of ticagrelor in elderly patients or those with a low body weight presenting with an acute coronary syndrome (ACS) are unknown.. ..The efficacy and safety of a reduced dose of prasugrel versus a standard dose of ticagrelor in elderly patients or… Continue reading Age- and Weight-Adapted Dose of #Prasugrel Versus Standard Dose of #Ticagrelor in Patients With Acute #Coronary Syndromes
#Dexamethasone in Hospitalized Patients with #Covid-19 — Preliminary Report
Coronavirus disease 2019 (Covid-19) is associated with diffuse lung damage. Glucocorticoids may modulate inflammation-mediated lung injury and thereby reduce progression to respiratory failure and death In this controlled, open-label trial comparing a range of possible treatments in patients who were hospitalized with Covid-19, we randomly assigned patients to receive oral or intravenous dexamethasone (at a… Continue reading #Dexamethasone in Hospitalized Patients with #Covid-19 — Preliminary Report
Acute pulmonary #embolism in patients with obstructive #sleep apnea: frequency, hospital outcomes, and recurrence
The objectives of this study were to assess the effect of obstructive sleep apnea (OSA) on the risk of acute pulmonary embolism (PE), hospital outcomes including mortality, and PE recurrence.. ..Of 25,038 patients, 3,184 (13%) had OSA and 283 (1.1%) experienced PE. Frequency of PE in patients with and without OSA was 2.4% versus 0.9%… Continue reading Acute pulmonary #embolism in patients with obstructive #sleep apnea: frequency, hospital outcomes, and recurrence
Predicting #personality from patterns of behavior collected with #smartphones
Smartphones enjoy high adoption rates around the globe. Rarely more than an arm’s length away, these sensor-rich devices can easily be repurposed to collect rich and extensive records of their users’ behaviors (e.g., location, communication, media consumption), posing serious threats to individual privacy. Here we examine the extent to which individuals’ Big Five personality dimensions… Continue reading Predicting #personality from patterns of behavior collected with #smartphones
#Probiotic Properties of #Escherichia coli Nissle in Human Intestinal Organoids
Probiotic, or beneficial, bacteria, such as E. coli Nissle, hold promise for the treatment of human disease. More study is needed to fully realize the potential of probiotics. Safety and efficacy studies are critically important; however, mice are poor models for many human intestinal diseases. We used stem cell-derived human intestinal organoid tissues to evaluate… Continue reading #Probiotic Properties of #Escherichia coli Nissle in Human Intestinal Organoids
Rapid Gel Card Agglutination Assays for Serological Analysis Following #SARS-CoV-2 Infection in Humans
High-throughput and rapid serology assays to detect the antibody response specific to severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) in human blood samples are urgently required to improve our understanding of the effects of COVID-19 across the world. Short-term applications include rapid case identification and contact tracing to limit viral spread, while population screening to determine the… Continue reading Rapid Gel Card Agglutination Assays for Serological Analysis Following #SARS-CoV-2 Infection in Humans
High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger #Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease
The clinical spectra of irritable bowel syndrome (#IBS) and inflammatory bowel disease (#IBD) intersect to form a scantily defined overlap syndrome, termed pre-IBD. We show that increased Enterobacteriaceae and reduced Clostridia abundance distinguish the fecal microbiota of pre-IBD patients from IBS patients. A history of antibiotics in individuals consuming a high-fat diet was associated with… Continue reading High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger #Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease
Nonalcoholic Fatty #Liver Disease and Advanced Fibrosis in US Adults Across Blood Pressure Categories
Nonalcoholic fatty liver disease (#NAFLD) is common in patients with hypertension but controversy exists as to whether screening for this condition should be performed. Here, we evaluate the prevalence of NAFLD and advanced fibrosis in US adults across blood pressure categories and estimate the number of patients who require referral to hepatologists. In this cross-sectional… Continue reading Nonalcoholic Fatty #Liver Disease and Advanced Fibrosis in US Adults Across Blood Pressure Categories
