There is concern about the potential of an increased risk related to medications that act on the renin–angiotensin–aldosterone system in patients exposed to coronavirus disease 2019 (Covid-19), because the viral receptor is angiotensin-converting enzyme 2 (ACE2).. ..Among 12,594 patients who were tested for Covid-19, a total of 5894 (46.8%) were positive; 1002 of these patients… Continue reading Renin–Angiotensin–Aldosterone System Inhibitors and Risk of Covid-19
Effects of changes in #smoking status on blood pressure among adult males and females in Indonesia: a 15-year population-based cohort study
The continuing rise of smoking behaviours will inevitably lead to a further increase in hypertension prevalence. However, limited research has examined the impacts of changes in smoking status on blood pressure (BP). We sought to assess correlations between increases or decreases of males’ and females’ cigarette consumption on systolic blood pressure (SBP), diastolic blood pressure… Continue reading Effects of changes in #smoking status on blood pressure among adult males and females in Indonesia: a 15-year population-based cohort study
Association between #Mental Disorders and Subsequent Medical Conditions
..A total of 698,874 of 5,940,299 persons (11.8%) were identified as having a mental disorder. The median age of the total population was 32.1 years at entry into the cohort and 48.7 years at the time of the last follow-up. Persons with a mental disorder had a higher risk than those without such disorders with… Continue reading Association between #Mental Disorders and Subsequent Medical Conditions
L-Thyroxine Therapy for Older Adults With Subclinical #Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial
..132 participants had Hypothyroid Symptoms scores greater than 30, and 133 had Tiredness scores greater than 40. Among the group with high symptom burden, the Hypothyroid Symptoms score improved similarly between those receiving L-thyroxine (mean within-group change, −12.3 [95% CI, −16.6 to −8.0]) and those receiving placebo (mean within-group change, −10.4 [CI, −15.3 to −5.4])… Continue reading L-Thyroxine Therapy for Older Adults With Subclinical #Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial
A Comparison of Biomarker Rise in Type 1 and Type 2 Myocardial Infarction
..Type 1 myocardial infarction tended to be larger than type 2 myocardial infarction, with a significantly higher mean percentage rise for both cTnT and CK-MB as well as higher mean RULN (207 vs 86 for cTnT, P = 0.02; 9 vs 4 for CK-MB, P = 0.002). There was a trend toward a higher rise… Continue reading A Comparison of Biomarker Rise in Type 1 and Type 2 Myocardial Infarction
Epidemiology of #Seasonal Coronaviruses: Establishing the Context for the Emergence of #Coronavirus Disease 2019
Public health preparedness for coronavirus (CoV) disease 2019 (COVID-19) is challenging in the absence of setting-specific epidemiological data. Here we describe the epidemiology of seasonal CoVs (sCoVs) and other cocirculating viruses in the West of Scotland, United Kingdom. We analyzed routine diagnostic data for >70 000 episodes of respiratory illness tested molecularly for multiple respiratory… Continue reading Epidemiology of #Seasonal Coronaviruses: Establishing the Context for the Emergence of #Coronavirus Disease 2019
#Circadian rhythm and sleep alterations in older people with lifetime #depression: a case-control study
Depression is common in older people and is associated with underlying brain change increasing the risk of dementia. Sleep disturbance is frequently reported by those with lifetime depression, however whether circadian misalignment also exists is unclear. We aimed to examine circadian rhythms and sleep associations in older patients with and without lifetime depression.. ..Participants underwent… Continue reading #Circadian rhythm and sleep alterations in older people with lifetime #depression: a case-control study
High incidence of #hepatocellular carcinoma and #cirrhotic complications in patients with psychiatric illness: a territory-wide cohort study
Because of high-risk behaviours, sedentary lifestyle and side effects of medications, psychiatric patients are at risk of viral hepatitis, alcohol-related liver disease and non-alcoholic fatty liver disease. We aimed to study the incidence of hepatocellular carcinoma (HCC) and cirrhotic complications in psychiatric patients.. ..We included 105,763 psychiatric patients without prior liver-related events in the final… Continue reading High incidence of #hepatocellular carcinoma and #cirrhotic complications in patients with psychiatric illness: a territory-wide cohort study
Mathematical Modeling of Interaction between Innate and Adaptive #Immune Responses in #COVID‐19 and Implications for Viral Pathogenesis
We have applied mathematical modeling to investigate the infections of the ongoing COVID‐19 pandemic caused by SARS‐CoV‐2 virus. We first validated our model using the well‐studied influenza viruses and then compared the pathogenesis processes between the two viruses. The interaction between host innate and adaptive immune responses was found to be a potential cause for… Continue reading Mathematical Modeling of Interaction between Innate and Adaptive #Immune Responses in #COVID‐19 and Implications for Viral Pathogenesis
2 Medical News 