In many cases, interactions among host, pathogen, and environment are insufficient to describe disease dynamics in the wild. The host microbiome plays an important role in host immunity, at the interface between the host and the pathogen, and affects disease outcome. The environment, as well as environmental microbiomes, influence the host microbiome, and also influence… Continue reading Environmental Factors and Host Microbiomes Shape Host–Pathogen Dynamics
Trace element deficiency is highly prevalent and associated with infection and mortality in patients with alcoholic hepatitis
Malnutrition is common in patients with alcohol‐related liver disease and is associated with outcome in patients with alcoholic hepatitis. Trace elements (cobalt, copper, iron, selenium and zinc) are micronutrients essential for many cellular processes including antioxidant pathways. The prevalence and relevance of trace element deficiency is unknown in alcoholic hepatitis. ..Sera from 302 patients with… Continue reading Trace element deficiency is highly prevalent and associated with infection and mortality in patients with alcoholic hepatitis
Skeletal muscle antagonizes antiviral CD8+ T cell exhaustion
CD8+ T cells become functionally impaired or “exhausted” in chronic infections, accompanied by unwanted body weight reduction and muscle mass loss. Whether muscle regulates T cell exhaustion remains incompletely understood. We report that mouse skeletal muscle increased interleukin (IL)–15 production during LCMV clone 13 chronic infection. Muscle-specific ablation of Il15 enhanced the CD8+ T cell… Continue reading Skeletal muscle antagonizes antiviral CD8+ T cell exhaustion
An Afternoon Hummus Snack Affects Diet Quality, Appetite, and Glycemic Control in Healthy Adults
..Thirty-nine adults (age: 26 ± 1 y; BMI: 24.4 ± 0.5 kg/m2) randomly completed the following afternoon snack patterns for 6 d/pattern: hummus and pretzels [HUMMUS; 240 kcal; 6 g protein, 31 g carbohydrate (2 g sugar), 11 g fat]; granola bars [BARS; 240 kcal; 4 g protein, 38 g carbohydrate (16 g sugar), 9… Continue reading An Afternoon Hummus Snack Affects Diet Quality, Appetite, and Glycemic Control in Healthy Adults
Echocardiographic Characterization of Female Professional Basketball Players in the US
..Echocardiographic variables included left ventricular (LV) dimensions, wall thickness, mass, prevalence of LV hypertrophy, aortic dimensions, right ventricular (RV) dimension, and right and left atrial size. Linear regression was used to assess the associations between cardiac structure and function with body size quantified as body surface area (BSA) in the primary analysis. Results A total… Continue reading Echocardiographic Characterization of Female Professional Basketball Players in the US
Smartphone use and primary #headache A cross-sectional hospital-based study
In a cross-sectional study between June 2017 and December 2018, patients with primary headache were divided into 2 groups: smartphone users (SUs) and non-smartphone users (NSUs). A questionnaire was administered for headache characteristics and treatment taken. The primary objective was to determine the association of smartphone use with new-onset headache or increase severity. The secondary… Continue reading Smartphone use and primary #headache A cross-sectional hospital-based study
CDC people at risk of devere COVID-19 illness
..CDC has removed the specific age threshold from the older adult classification. CDC now warns that among adults, risk increases steadily as you age, and it’s not just those over the age of 65 who are at increased risk for severe illness.. ..There was consistent evidence (from multiple small studies or a strong association from… Continue reading CDC people at risk of devere COVID-19 illness
Reversing a model of #Parkinson’s disease with in situ converted nigral neurons
Parkinson’s disease is characterized by loss of dopamine neurons in the substantia nigra1. Similar to other major neurodegenerative disorders, there are no disease-modifying treatments for Parkinson’s disease. While most treatment strategies aim to prevent neuronal loss or protect vulnerable neuronal circuits, a potential alternative is to replace lost neurons to reconstruct disrupted circuits2. Here we… Continue reading Reversing a model of #Parkinson’s disease with in situ converted nigral neurons
Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study
Increasing evidence supports reciprocal communication between the enteric and the central nervous system in disease, termed the ‘gut–brain axis’. Recent findings suggest a connection between IBD and development of Parkinson’s disease. The role of IBD in dementia, another insidious neurodegenerative disorder, has not been explored.. ..Overall incidence of dementia among patients with IBD was significantly… Continue reading Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study
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