Objective: Experimental evidence suggests that inadequate sleep disrupts next-day affective processing and evokes greater stress reactivity. However, less research has focused on whether sleep predicts next-day affective reactivity to naturally occurring stressors and positive events in daily life, as well as the reversed direction of association (i.e., affective reactivity to daily events as predictors of… Continue reading #Sleep duration and affective reactivity to #stressors and positive events in daily life
Once-Weekly #Insulin for Type 2 #Diabetes without Previous Insulin Treatment
It is thought that a reduction in the frequency of basal insulin injections might facilitate treatment acceptance and adherence among patients with type 2 diabetes. Insulin icodec is a basal insulin analogue designed for once-weekly administration that is in development for the treatment of diabetes We conducted a 26-week, randomized, double-blind, double-dummy, phase 2 trial… Continue reading Once-Weekly #Insulin for Type 2 #Diabetes without Previous Insulin Treatment
Risk for Serious #Infection With Low-Dose #Glucocorticoids in Patients With #Rheumatoid Arthritis
Low-dose glucocorticoids are frequently used for the management of rheumatoid arthritis (RA) and other chronic conditions, but the safety of long-term use remains uncertain.. ..Associations between glucocorticoid dose (none, ≤5 mg/d, >5 to 10 mg/d, and >10 mg/d) and hospitalized infection were evaluated using inverse probability–weighted analyses, with 1-year cumulative incidence predicted from weighted models.… Continue reading Risk for Serious #Infection With Low-Dose #Glucocorticoids in Patients With #Rheumatoid Arthritis
#Anticoagulation Timing in Cardioembolic #Stroke and Recurrent Event Risk
Guidelines recommend initiating anticoagulation within 4 to 14 days after cardioembolic stroke. Data supporting this did not account for key factors potentially affecting the decision to initiate anticoagulation, such as infarct size, hemorrhagic transformation, or high‐risk features on echocardiography.. ..We pooled data from stroke registries of 8 comprehensive stroke centers across the United States. We included… Continue reading #Anticoagulation Timing in Cardioembolic #Stroke and Recurrent Event Risk
Interventions to Improve #Statin Tolerance and Adherence in Patients at Risk for #Cardiovascular Disease
Strategies to improve patients' tolerance of and adherence to statins may enhance the effectiveness of dyslipidemia treatment in those at risk for cardiovascular disease (CVD).. ..One SR, 1 RCT, and 4 cohort studies were included. The SR found that intensified patient care improved adherence and decreased levels of total serum cholesterol and low-density lipoprotein cholesterol… Continue reading Interventions to Improve #Statin Tolerance and Adherence in Patients at Risk for #Cardiovascular Disease
The unfolding #COVID-19 pandemic: A probability-based, nationally representative study of #mental health in the U.S.
The COVID-19 pandemic is a collective stressor unfolding over time, yet rigorous published empirical studies addressing mental health consequences of COVID-19 among large probability-based national samples are rare. Between 3/18-4/18/20, during an escalating period of illness and death in the United States, we assessed acute stress, depressive symptoms and direct, community, and media-based exposures to… Continue reading The unfolding #COVID-19 pandemic: A probability-based, nationally representative study of #mental health in the U.S.
#Loneliness and type 2 #diabetes incidence: findings from the English Longitudinal Study of Ageing
Loneliness is associated with all-cause mortality and coronary heart disease. However, the prospective relationship between loneliness and type 2 diabetes onset is unclear.. ..A total of 264 (6.42%) participants developed type 2 diabetes over the follow-up period. Loneliness was a significant predictor of incident type 2 diabetes (HR 1.46; 95% CI 1.15, 1.84; p = 0.002) independent… Continue reading #Loneliness and type 2 #diabetes incidence: findings from the English Longitudinal Study of Ageing
Chest x-ray findings and temporal #lung changes in patients with #COVID-19 pneumonia
Chest CT scan and chest x-rays show characteristic radiographic findings in patients with COVID-19 pneumonia. Chest x-ray can be used in diagnosis and follow up in patients with COVID-19 pneumonia. The study aims at describing the chest x-ray findings and temporal radiographic changes in COVID-19 patients.. ..A total of 88 patients (50 (56.8%) females and… Continue reading Chest x-ray findings and temporal #lung changes in patients with #COVID-19 pneumonia
#Bile Acids Signal via TGR5 to Activate #Intestinal Stem Cells and Epithelial Regeneration
Renewal and patterning of the intestinal epithelium is coordinated by intestinal stem cells (ISCs); dietary and metabolic factors provide signals to the niche that control ISC activity. Bile acids (BAs), metabolites in the gut, signal nutrient availability by activating the G protein-coupled bile acid receptor 1 (GPBAR1, also called TGR5). TGR5 is expressed in the… Continue reading #Bile Acids Signal via TGR5 to Activate #Intestinal Stem Cells and Epithelial Regeneration
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