This study aimed to investigate whether the drug-specific and dosage effects of statin use were associated with a lower risk of cancer in adults in South Korea. We evaluated the adult population registered in the 2010 sample cohort database of South Korea. Subjects were divided into the statin group (those who had been prescribed continuous… Continue reading Drug-specific and dosage effects of #statins and the risk of #cancer: a population-based cohort study in South Korea
Association of Glycolysis-Enhancing α-1 Blockers With Risk of Developing #Parkinson Disease
Parkinson disease (PD) is a common neurodegenerative disease. A treatment that prevents or delays development of PD is a critical unmet need. Terazosin and closely related drugs were recently discovered to enhance glycolysis and reduce PD progression in animal models and human clinical databases.. ..A cohort of 52 365 propensity score–matched pairs of terazosin/doxazosin/alfuzosin and tamsulosin… Continue reading Association of Glycolysis-Enhancing α-1 Blockers With Risk of Developing #Parkinson Disease
#Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized #COVID-19 patients
Patients with coronavirus disease-19 (COVID-19) are at high risk for thrombotic arterial and venous occlusions. However, bleeding complications have also been observed in some patients. Understanding the balance between coagulation and fibrinolysis will help inform optimal approaches to thrombosis prophylaxis and potential utility of fibrinolytic-targeted therapies. 118 hospitalized COVID-19 patients and 30 healthy controls were… Continue reading #Plasma tissue plasminogen activator and plasminogen activator inhibitor-1 in hospitalized #COVID-19 patients
Fecal #microbiota transplant overcomes resistance to anti–PD-1 therapy in #melanoma patients
Anti–programmed cell death protein 1 (PD-1) therapy provides long-term clinical benefits to patients with advanced melanoma. The composition of the gut microbiota correlates with anti–PD-1 efficacy in preclinical models and cancer patients. To investigate whether resistance to anti–PD-1 can be overcome by changing the gut microbiota, this clinical trial evaluated the safety and efficacy of… Continue reading Fecal #microbiota transplant overcomes resistance to anti–PD-1 therapy in #melanoma patients
Relationship between afternoon #napping and #cognitive function in the ageing Chinese population
Background Several studies have shown that afternoon napping promotes cognitive function in the elderly; on the other hand, some studies have shown opposite results. This current study further examined the relationship between afternoon napping and cognitive function in the ageing Chinese population. Methods A total of 2214 elderly were included (napping group: n=1534; non-napping group:… Continue reading Relationship between afternoon #napping and #cognitive function in the ageing Chinese population
#COVID-19 Outcomes Among Persons Living With or Without Diagnosed #HIV Infection in New York State
New York State has been an epicenter for both the US coronavirus disease 2019 (COVID-19) and HIV/AIDS epidemics. Persons living with diagnosed HIV may be more prone to COVID-19 infection and severe outcomes, yet few studies have assessed this possibility at a population level.. ..A total of 2988 persons living with diagnosed HIV (2109 men… Continue reading #COVID-19 Outcomes Among Persons Living With or Without Diagnosed #HIV Infection in New York State
#Adipose saturation reduces #lipotoxic systemic inflammation and explains the #obesity paradox
Obesity sometimes seems protective in disease. This obesity paradox is predominantly described in reports from the Western Hemisphere during acute illnesses. Since adipose triglyceride composition corresponds to long-term dietary patterns, we performed a meta-analysis modeling the effect of obesity on severity of acute pancreatitis, in the context of dietary patterns of the countries from which… Continue reading #Adipose saturation reduces #lipotoxic systemic inflammation and explains the #obesity paradox
Screening for Asymptomatic #Carotid #Artery Stenosis Lack of Clinical Benefit, Potential for Harm
In the Recommendation Statement published in this issue of JAMA,1 the US Preventive Services Task Force (USPTF) has reaffirmed its 2014 recommendation, stating that “The USPTF recommends against screening for asymptomatic carotid artery stenosis in the general adult population (D recommendation),” based on evidence that the harms of screening for carotid artery stenosis in asymptomatic… Continue reading Screening for Asymptomatic #Carotid #Artery Stenosis Lack of Clinical Benefit, Potential for Harm
Time-restricted #feeding normalizes hyperinsulinemia to inhibit #breast cancer in obese postmenopausal mouse models
Accumulating evidence indicates that obesity with its associated metabolic dysregulation, including hyperinsulinemia and aberrant circadian rhythms, increases the risk for a variety of cancers including postmenopausal breast cancer. Caloric restriction can ameliorate the harmful metabolic effects of obesity and inhibit cancer progression but is difficult to implement and maintain outside of the clinic. In this… Continue reading Time-restricted #feeding normalizes hyperinsulinemia to inhibit #breast cancer in obese postmenopausal mouse models
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