There is a lack of robust data on significant gastrointestinal bleeding in older people using aspirin. We calculated the incidence, risk factors and absolute risk using data from a large randomised, controlled trial. Design Data were extracted from an aspirin versus placebo primary prevention trial conducted throughout 2010–2017 (‘ASPirin in Reducing Events in the Elderly… Continue reading Major GI #bleeding in older persons using #aspirin: incidence and risk factors in the ASPREE randomised controlled trial
#Statin use is associated with lower prevalence of advanced liver #fibrosis in patients with type 2 diabetes
Patients with type 2 diabetes (T2D) are at increased risk of both cardiovascular disease (CVD) and advanced liver fibrosis related to non-alcoholic fatty liver disease (NAFLD). Statin use is known to reduce the incidence of CVD while evidence on an effect on NAFLD severity is limited. Methods This is a cross-sectional study performed with data… Continue reading #Statin use is associated with lower prevalence of advanced liver #fibrosis in patients with type 2 diabetes
Risk for recurrent #cardiovascular disease events among patients with #diabetes and chronic kidney disease
Adults who have experienced multiple cardiovascular disease (CVD) events have a very high risk for additional events. Diabetes and chronic kidney disease (CKD) are each associated with an increased risk for recurrent CVD events following a myocardial infarction (MI). Methods We compared the risk for recurrent CVD events among US adults with health insurance who… Continue reading Risk for recurrent #cardiovascular disease events among patients with #diabetes and chronic kidney disease
KCNQ5 Potassium Channel Activation Underlies #Vasodilation by #Tea
Tea, produced from the evergreen Camellia sinensis, has reported therapeutic properties against multiple pathologies, including hypertension. Although some studies validate the health benefits of tea, few have investigated the molecular mechanisms of action. The KCNQ5 voltage-gated potassium channel contributes to vascular smooth muscle tone and neuronal M-current regulation. Methods: We applied electrophysiology, myography, mass spectrometry… Continue reading KCNQ5 Potassium Channel Activation Underlies #Vasodilation by #Tea
ACG Clinical Guidelines: #Colorectal #Cancer Screening 2021
1. We recommend CRC screening in average-risk individuals between ages 50 and 75 years to reduce incidence of advanced adenoma, CRC, and mortality from CRC. Strong recommendation; moderate-quality evidence 2. We suggest CRC screening in average-risk individuals between ages 45 and 49 years to reduce incidence of advanced adenoma, CRC, and mortality from CRC. Conditional… Continue reading ACG Clinical Guidelines: #Colorectal #Cancer Screening 2021
The gut #mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to #diet
As an active interface between the host and their diet, the gut microbiota influences host metabolic adaptation; however, the contributions of fungi have been overlooked. Here, we investigate whether variations in gut mycobiome abundance and composition correlate with key features of host metabolism. We obtained animals from four commercial sources in parallel to test if… Continue reading The gut #mycobiome of healthy mice is shaped by the environment and correlates with metabolic outcomes in response to #diet
A Pragmatic, Randomized Clinical Trial of Gestational #Diabetes Screening
Gestational diabetes mellitus is common and is associated with an increased risk of adverse maternal and perinatal outcomes. Although experts recommend universal screening for gestational diabetes, consensus is lacking about which of two recommended screening approaches should be used. METHODS We performed a pragmatic, randomized trial comparing one-step screening (i.e., a glucose-tolerance test in which… Continue reading A Pragmatic, Randomized Clinical Trial of Gestational #Diabetes Screening
Low #Zinc Levels at Admission Associates with Poor Clinical Outcomes in #SARS-CoV-2 Infection
Background: Zinc is an essential micronutrient that impacts host–pathogen interplay at infection. Zinc balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases, two groups with an increased risk for severe severe coronavirus disease 2019 (COVID-19)… Continue reading Low #Zinc Levels at Admission Associates with Poor Clinical Outcomes in #SARS-CoV-2 Infection
Broadened Eligibility for #Lung #Cancer Screening Challenges and Uncertainty for Implementation and Equity
In 2013, the US Preventive Services Task Force (USPSTF) recommended annual lung cancer screening with low-dose computed tomography (CT) in US adults aged 55 to 80 years who currently smoke or formerly smoked with a 30 pack-year history, and for those who formerly smoked, quitting within the past 15 years (grade “B” recommendation).1 In this… Continue reading Broadened Eligibility for #Lung #Cancer Screening Challenges and Uncertainty for Implementation and Equity
2 Medical News 